The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Studying complex biological systems using multifactorial perturbation
Open accessAbstract
High-throughput genomics, transcriptomics, proteomics and metabolomics have the potential to identify the functional consequences of induced and natural genetic variation. Surprisingly, the experiments of most genomics researchers still mainly involve perturbing a biological system of interest by modifying either one factor or one gene at a time. By contrast, this article argues that multifactorial experimentation would allow the study of many more biologically relevant questions in parallel at the same or lower cost.
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Identification of the Cystic Fibrosis Gene: Genetic Analysis
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A genomic regulatory network for development
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Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays.
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Cited by
The Human Gut Microbiome: From Association to Modulation
Schmidt, T. S. B., Raes, J., & Bork, P. (2018) · Cell · doi:10.1016/j.cell.2018.02.044 · Cited by 845
Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors
Yvert, G., Brem, R. B., Whittle, J., Akey, J. M., Foss, E., Smith, E. N., Mackelprang, R., & Kruglyak, L. (2003) · Nature Genetics · doi:10.1038/ng1222 · Cited by 632
The genetics of plant metabolism
Keurentjes, J. J. B., Fu, J., de Vos, C. H. R., Lommen, A., Hall, R. D., Bino, R. J., van der Plas, L. H. W., Jansen, R. C., Vreugdenhil, D., & Koornneef, M. (2006) · Nature Genetics · doi:10.1038/ng1815 · Cited by 499
Self-citationIntegrating physical and genetic maps: from genomes to interaction networks
Beyer, A., Bandyopadhyay, S., & Ideker, T. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2144 · Cited by 207
Mapping, Fine Mapping, and Molecular Dissection of Quantitative Trait Loci in Domestic Animals
Georges, M. (2007) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.8.080706.092408 · Cited by 132
Metadata
- Authors
- Jansen, R. C.
- Venue
- Nature Reviews Genetics
- Published
- 2003-02
- Volume
- 4
- Issue
- 2
- Pages
- 145-151
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2171151258
- Cited by
- 187
- References
- 6
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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