Mapping, Fine Mapping, and Molecular Dissection of Quantitative Trait Loci in Domestic Animals
Abstract
Artificial selection has created myriad breeds of domestic animals, each characterized by unique phenotypes pertaining to behavior, morphology, physiology, and disease. Most domestic animal populations share features with isolated founder populations, making them well suited for positional cloning. Genome sequences are now available for most domestic species, and with them a panoply of tools including high-density single-nucleotide polymorphism panels. As a result, domestic animal populations are becoming invaluable resources for studying the molecular architecture of complex traits and of adaptation. Here we review recent progress and issues in the positional identification of genes underlying complex traits in domestic animals. As many phenotypes studied in animals are quantitative, we focus on mapping, fine mapping, and cloning of quantitative trait loci.
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The authors provide exon-level annotation of genes that have contributed to livestock domestication and desirable commercial traits.
“As a first step to support a possible future marker assisted selection scheme152–154 for the muskox, we provide exon-level annotation of genes that have contributed to livestock domestication (Supplementary Table S8) and desirable commercial traits such as meat and dairy production, wool quality, prolificity, and heat tolerance155–159 (Supplementary Table S9).”
From Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics (2024) · cites this paper as [152]
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Self-citation
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Lok, S., Lau, T. N. H., Trost, B., Tong, A. H. Y., Paton, T., Wintle, R. F., Engstrom, M. D., Gunn, A., & Scherer, S. W. (2024) · Scientific Reports · doi:10.1038/s41598-024-67270-9 · Cited by 4 · see citing works
“As a first step to support a possible future marker assisted selection scheme 152–154 for the muskox, we provide exon-level annotation of genes that have contributed to livestock domestication (Supplementary Table S8) and desirable commercial traits such as meat and dairy production, wool quality,…”
Background
- Authors
- Georges, M.
- Affiliations
- University of Liège (BE)
- Corresponding author
- Georges, Michel
- ORCID
- Georges, Michel
- Venue
- Annual Review of Genomics and Human Genetics
- Publisher
- Annual Reviews
- Published
- 2007-09-01
- Volume
- 8
- Issue
- 1
- Pages
- 131-162
- ISSN
- 1527-8204 (ISSN-L)
- 1545-293X
- OpenAlex
- W2097064013
- Cited by
- 132
- References
- 115
- Citations by year
- 2024: 3 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 8 · 2015: 11 · 2014: 15 · 2013: 10 · 2012: 14
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Genomics and Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- quantitative trait loci, domestic animals, positional cloning, fine mapping, complex traits, selective breeding, founder populations, single nucleotide polymorphisms, molecular dissection, adaptation, animal breeding
- MeSH terms
- Animals, Animals, Domestic, Chromosome Mapping, Cloning, Molecular, Genetic Markers, Inbreeding, Genetic Linkage, Models, Biological, Models, Genetic, Pedigree, Recombination, Genetic, Selection, Genetic, Genetic Variation, Genomic Imprinting, Founder Effect, Quantitative Trait Loci
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