The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Human hepatocyte transplantation: current experience and future challenges
Abstract
Hepatocyte transplantation has shown potential as an additional treatment modality for certain diseases of the liver. To date, patients with liver-based metabolic disorders or acute liver failure have undergone hepatocyte transplantation in several centers around the world. Results from individual patients are promising, especially for the treatment of liver-based metabolic disorders, but the lack of controlled trials makes the interpretation of the findings difficult. The current source of isolated hepatocytes is donor organs that are unused or deemed unsuitable for liver transplantation. Hence the major challenge that this field is facing is the limited supply of donor organs that can provide good quality cells. Alternative sources of cells, including stem cells, are under investigation. This Review discusses the current bench-to-bedside issues and future challenges that need to be faced to allow the wider application of hepatocyte transplantation.
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In the citing paper
“Transplantation of primary hepatocytes has been evaluated as an alternative to organ transplantation both in clinics and animal models (Dhawan et al., 2010”
From In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity (2018) · cites this paper as Dhawan et al., 2010
In the citing paper
“For late-stage liver diseases in which the liver loses its regeneration capability, the only curative therapy is liver transplantation (Dhawan et al., 2010”
From In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity (2018) · cites this paper as Dhawan et al., 2010
In the citing paper
“Because about 10% of liver cells must be replaced to have therapeutic effect on human patients (Dhawan et al., 2010”
From In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity (2018) · cites this paper as Dhawan et al., 2010
In the citing paper
“Because for some liver diseases a repopulation of 10% would be sufficient to show therapeutic effect (Dhawan et al., 2010”
From In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity (2018) · cites this paper as Dhawan et al., 2010
Citations
Cites
Bone Marrow as a Potential Source of Hepatic Oval Cells
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Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
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Cell fusion is the principal source of bone-marrow-derived hepatocytes
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Iron oxide MR contrast agents for molecular and cellular imaging
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Liver from bone marrow in humans
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Treatment of the Crigler–Najjar Syndrome Type I with Hepatocyte Transplantation
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Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice
Azuma, H., Paulk, N., Ranade, A., Dorrell, C., Al-Dhalimy, M., Ellis, E., Strom, S., Kay, M. A., Finegold, M., & Grompe, M. (2007) · Nature Biotechnology · doi:10.1038/nbt1326 · Cited by 835
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Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells
Fausto, N. (2004) · Hepatology · doi:10.1002/hep.20214 · Cited by 720
Research works printed but not linked: 1
- Strom, S. C., Dorko, K., Thompson, M. T., Pisarov, L. A. & Nussler, A. K. in Îlots de Langerhans et hépatocytes: vers une utilisation therapeutique (eds Franco, D., Boudjema, K. & Varet, B.) 195–205 (Les Editions INSERM, Paris, 1998).
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Sorted by citations
Zhang, W., Wang, R., Sun, Z., Zhu, X., Zhao, Q., Zhang, T., Cholewinski, A., Yang, F. K., Zhao, B., Pinnaratip, R., et al. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00285e · Cited by 994
Supramolecular Adhesive Hydrogels for Tissue Engineering Applications
Zhao, Y., Song, S., Ren, X., Zhang, J., Lin, Q., & Zhao, Y. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00815 · Cited by 714
Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes
Huang, P., Zhang, L., Gao, Y., He, Z., Yao, D., Wu, Z., Cen, J., Chen, X., Liu, C., Hu, Y., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.01.003 · Cited by 560
Acetaminophen hepatotoxicity: an updated review
Lancaster, E. M., Hiatt, J. R., & Zarrinpar, A. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1432-2 · Cited by 337
Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming
Du, Y., Wang, J., Jia, J., Song, N., Xiang, C., Xu, J., Hou, Z., Su, X., Liu, B., Jiang, T., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.01.008 · Cited by 320
Metadata
- Authors
- Dhawan, A., Puppi, J., Hughes, R. D., & Mitry, R. R.
- Affiliations
- King's College Hospital (GB)
- King's College London (GB)
- Corresponding author
- Dhawan, Anil
- ORCID
- Dhawan, Anil
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2010-04-06
- Volume
- 7
- Issue
- 5
- Pages
- 288-298
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- OpenAlex
- W1999889167
- Cited by
- 362
- References
- 117
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 21 · 2023: 21 · 2022: 22 · 2021: 13 · 2020: 29 · 2019: 31 · 2018: 39 · 2017: 20 · 2016: 18 · 2015: 29 · 2014: 30 · 2013: 29 · 2012: 28
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- hepatocyte transplantation, metabolic liver disease, acute liver failure, organ shortage, stem cell sources, cell therapy, bench-to-bedside translation
- MeSH terms
- Animals, Humans, Treatment Outcome, Liver Failure, Cell Transplantation, Hepatocytes
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