Cited by 365Organ Transplantation Techniques and OutcomesLiver physiology and pathologyTissue Engineering and Regenerative Medicine

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Human hepatocyte transplantation: current experience and future challenges

Dhawan, Anil, Puppi, Juliana, Hughes, Robin D., Mitry, Ragai R.·2010·Nature Reviews Gastroenterology & Hepatology

DOI 10.1038/nrgastro.2010.44

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Abstract

Hepatocyte transplantation has shown potential as an additional treatment modality for certain diseases of the liver. To date, patients with liver-based metabolic disorders or acute liver failure have undergone hepatocyte transplantation in several centers around the world. Results from individual patients are promising, especially for the treatment of liver-based metabolic disorders, but the lack of controlled trials makes the interpretation of the findings difficult. The current source of isolated hepatocytes is donor organs that are unused or deemed unsuitable for liver transplantation. Hence the major challenge that this field is facing is the limited supply of donor organs that can provide good quality cells. Alternative sources of cells, including stem cells, are under investigation. This Review discusses the current bench-to-bedside issues and future challenges that need to be faced to allow the wider application of hepatocyte transplantation.

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Authors: Dhawan, A., Puppi, J., Hughes, R. D., & Mitry, R. R.
Affiliations: King's College Hospital (GB)
King's College London (GB)
Corresponding author: Dhawan, Anil
ORCID: Dhawan, Anil
Venue: Nature Reviews Gastroenterology & Hepatology
Publisher: Springer Science and Business Media LLC
Published: 2010-04-06
Volume: 7
Issue: 5
Pages: 288-298
ISSN: 1759-5045 (ISSN-L)
1759-5053
DOI: 10.1038/nrgastro.2010.44
OpenAlex: W1999889167
Cited by: 362
References: 117
Citations by year: 2026: 5 · 2025: 11 · 2024: 21 · 2023: 21 · 2022: 22 · 2021: 13 · 2020: 29 · 2019: 31 · 2018: 39 · 2017: 20 · 2016: 18 · 2015: 29 · 2014: 30 · 2013: 29 · 2012: 28
FWCI: 4.15
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Gastroenterology & Hepatology (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords: hepatocyte transplantation, metabolic liver disease, acute liver failure, organ shortage, stem cell sources, cell therapy, bench-to-bedside translation
MeSH terms: Animals, Humans, Treatment Outcome, Liver Failure, Cell Transplantation, Hepatocytes

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Human hepatocyte transplantation: current experience and future challenges

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