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Cited by 273

The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.

Chemopreventive strategies in hepatocellular carcinoma

Open access
Singh, Siddharth, Singh, Preet Paul, Roberts, Lewis R., Sanchez, William·2014·Nature Reviews Gastroenterology & Hepatology
DOI 10.1038/nrgastro.2013.143
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Abstract

Hepatocellular carcinoma (HCC) is the third most common cause of death from cancer. The incidence and mortality of HCC are increasing in most Western countries as a result of an ageing cohort infected with chronic hepatitis C, and are expected to continue to rise as a consequence of the obesity epidemic. Chemopreventive strategies aimed at decreasing the risk or delaying the onset of HCC are needed. Universal immunization against HBV and antiviral therapy against HBV and HCV in patients with established disease has consistently been associated with reduced HCC risk, especially in patients who achieve sustained virologic response. However, the cost-effectiveness of antiviral therapy for primary HCC prevention is not known. Several commonly prescribed medications seem promising as chemopreventive agents against HCC, including statins, antidiabetic medications and aspirin. Dietary agents such as coffee, vitamin E and fish oil as well as phytochemicals might also be associated with reduced risk of HCC. Though randomized controlled trials are ideally needed to firmly establish efficacy, such chemoprevention trials are logistically and ethically challenging. Well-designed, prospective, population-based cohort studies might provide the best evidence for chemopreventive efficacy of these agents.

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Metadata

Authors
Singh, S., Singh, P. P., Roberts, L. R., & Sanchez, W.
Venue
Nature Reviews Gastroenterology & Hepatology
Publisher
Springer Science and Business Media LLC
Published
2013-08-13
Volume
11
Issue
1
Pages
45-54
ISSN
  • 1759-5045 (ISSN-L)
  • 1759-5053
DOI
10.1038/nrgastro.2013.143
OpenAlex
W2021181675
Cited by
273
References
111
FWCI
3.89
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Chemopreventive strategies in hepatocellular carcinoma. https://app.cochat.ai/papers/10.1038/nrgastro.2013.143
The paper
Singh, S., Singh, P. P., Roberts, L. R., & Sanchez, W. (2014). Chemopreventive strategies in hepatocellular carcinoma. Nature Reviews Gastroenterology & Hepatology. https://doi.org/10.1038/nrgastro.2013.143

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.