Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis
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Abstract
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for prevention and treatment are urgently needed. We previously reported that histone H4 acetylation is elevated in pancreatic acinar cells harboring Kras mutations prior to the appearance of premalignant lesions. Because acetyl-CoA abundance regulates global histone acetylation, we hypothesized that altered acetyl-CoA metabolism might contribute to metabolic or epigenetic alterations that promote tumorigenesis. We found that acetyl-CoA abundance is elevated in KRAS-mutant acinar cells and that its use in the mevalonate pathway supports acinar-to-ductal metaplasia (ADM). Pancreas-specific loss of the acetyl-CoA–producing enzyme ATP-citrate lyase (ACLY) accordingly suppresses ADM and tumor formation. In PDA cells, growth factors promote AKT–ACLY signaling and histone acetylation, and both cell proliferation and tumor growth can be suppressed by concurrent BET inhibition and statin treatment. Thus, KRAS-driven metabolic alterations promote acinar cell plasticity and tumor development, and targeting acetyl-CoA–dependent processes exerts anticancer effects. Significance: Pancreatic cancer is among the deadliest of human malignancies. We identify a key role for the metabolic enzyme ACLY, which produces acetyl-CoA, in pancreatic carcinogenesis. The data suggest that acetyl-CoA use for histone acetylation and in the mevalonate pathway facilitates cell plasticity and proliferation, suggesting potential to target these pathways. See related commentary by Halbrook et al., p. 326. This article is highlighted in the In This Issue feature, p. 305
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Oncogenic KRas increases acetyl-CoA and ROS before ADM develops, and inhibiting these phenotypes blocks ADM.
“Oncogenic KRas increases the levels of acetyl coenzyme A (CoA) and reactive oxygen species (ROS) before the development of ADM, and inhibiting these phenotypes blocks ADM (19, 20).”
From Metabolic reprogramming and cancer progression (2020) · cites this paper as [20]
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Martínez-Reyes, I., & Chandel, N. S. (2020) · Nature Communications · doi:10.1038/s41467-019-13668-3 · Cited by 2,813 · see citing works
Metabolic reprogramming and cancer progression
Faubert, B., Solmonson, A., & DeBerardinis, R. J. (2020) · Science · doi:10.1126/science.aaw5473 · Cited by 2,740 · see citing works
The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism
Hoxhaj, G., & Manning, B. D. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0216-7 · Cited by 2,137 · see citing works
Reprogramming of fatty acid metabolism in cancer
Koundouros, N., & Poulogiannis, G. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0650-z · Cited by 1,621 · see citing works
Bian, X., Liu, R. R., Meng, Y., Xing, D., Xu, D., & Lu, Z. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20201606 · Cited by 1,007 · see citing works
Metabolic reprogramming and epigenetic modifications on the path to cancer
Sun, L., Zhang, H., & Gao, P. (2021) · Protein & Cell · doi:10.1007/s13238-021-00846-7 · Cited by 796 · see citing works
Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer
Sivanand, S., & Heiden, M. G. V. (2020) · Cancer Cell · doi:10.1016/j.ccell.2019.12.011 · Cited by 488 · see citing works
Self-citationMetabolism of pancreatic cancer: paving the way to better anticancer strategies
Qin, C., Yang, G., Yang, J., Ren, B., Wang, H., Chen, G., Zhao, F., You, L., Wang, W., & Zhao, Y. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01169-7 · Cited by 415 · see citing works
Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
Zhang, S., Xiao, X., Yi, Y., Wang, X., Zhu, L., Shen, Y., Lin, D., & Wu, C. H. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01848-7 · Cited by 440 · see citing works
Finley, L. W. S. (2023) · Cell · doi:10.1016/j.cell.2023.01.038 · Cited by 331 · see citing works
The metabolic landscape of RAS-driven cancers from biology to therapy
Mukhopadhyay, S., Vander Heiden, M. G., & McCormick, F. (2021) · Nature Cancer · doi:10.1038/s43018-021-00184-x · Cited by 315 · see citing works
Acetyl-CoA metabolism in cancer
Guertin, D. A., & Wellen, K. E. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00543-5 · Cited by 303 · see citing works
Self-citationPhospholipids and cholesterol: Inducers of cancer multidrug resistance and therapeutic targets
Kopecka, J., Trouillas, P., Gašparović, A. Č., Gazzano, E., Assaraf, Y. G., & Riganti, C. (2019) · Drug Resistance Updates · doi:10.1016/j.drup.2019.100670 · Cited by 296 · see citing works
The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer
Fontana, F., Giannitti, G., Marchesi, S., & Limonta, P. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.89942 · Cited by 309 · see citing works
An Overview: The Diversified Role of Mitochondria in Cancer Metabolism
Liu, Y., Sun, Y., Guo, Y., Shi, X., Chen, X., Feng, W., Wu, L., Zhang, J., Yu, S., Wang, Y., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.81609 · Cited by 260 · see citing works
BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma
Li, J., Yin, M., Wang, D., Wang, J., Lei, M., Zhang, Y., Liu, Y., Zhang, L., Zou, S., Hu, L.-P., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-019-0455-6 · Cited by 248 · see citing works
ATP citrate lyase: A central metabolic enzyme in cancer
Icard, P., Wu, Z., Fournel, L., Coquerel, A., Lincet, H., & Alifano, M. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.12.010 · Cited by 240 · see citing works
Metabolic Reprogramming of Colorectal Cancer Cells and the Microenvironment: Implication for Therapy
Nenkov, M., Ma, Y., Gaßler, N., & Chen, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126262 · Cited by 222 · see citing works
Yang, S., Liu, Q., & Liao, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.607209 · Cited by 202 · see citing works
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Moonlighting functions of metabolic enzymes and metabolites in cancer
Pan, C., Li, B., & Simon, M. C. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.08.031 · Cited by 194 · see citing works
Statins as Anticancer Agents in the Era of Precision Medicine
Longo, J., van Leeuwen, J. E., Elbaz, M., Branchard, E., & Penn, L. Z. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-1967 · Cited by 196 · see citing works
The diversity and breadth of cancer cell fatty acid metabolism
Nagarajan, S. R., Butler, L. M., & Hoy, A. J. (2021) · Cancer & Metabolism · doi:10.1186/s40170-020-00237-2 · Cited by 187 · see citing works
Aberrant lipid metabolism as a therapeutic target in liver cancer
Pope, E. D., Kimbrough, E. O., Vemireddy, L. P., Surapaneni, P. K., Copland, J. A., & Mody, K. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1615883 · Cited by 183 · see citing works
Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer
Ippolito, L., Comito, G., Parri, M., Iozzo, M., Duatti, A., Virgilio, F., Lorito, N., Bacci, M., Pardella, E., Sandrini, G., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-0914 · Cited by 181 · see citing works
Fatty acid metabolism reprogramming in ccRCC: mechanisms and potential targets
Tan, S. K., Hougen, H. Y., Merchan, J. R., Gonzalgo, M. L., & Welford, S. M. (2022) · Nature Reviews Urology · doi:10.1038/s41585-022-00654-6 · Cited by 178 · see citing works
Xiang, W., Lv, H., Xing, F., Sun, X., Ma, Y., Wu, L. Y., Lv, G., Zong, Q., Wang, L., Wu, Z., et al. (2023) · Science Advances · doi:10.1126/sciadv.adi2465 · Cited by 161 · see citing works
Targeting the Mevalonate Pathway in Cancer
Juarez, D., & Fruman, D. A. (2021) · Trends in cancer · doi:10.1016/j.trecan.2020.11.008 · Cited by 160 · see citing works
Influence of cholesterol on cancer progression and therapy
Mayengbam, S. S., Singh, A., Pillai, A. D., & Bhat, M. K. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101043 · Cited by 155 · see citing works
Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis
Izzo, L., Trefely, S., Demetriadou, C., Drummond, J. M., Mizukami, T., Kuprasertkul, N., Farria, A. T., Nguyen, P. T., Murali, N., Reich, L. N., et al. (2023) · Science Advances · doi:10.1126/sciadv.adf0115 · Cited by 134 · see citing works
Self-citationLipid metabolism in pancreatic cancer: emerging roles and potential targets
Yin, X., Xu, R., Song, J., Ruze, R., Chen, Y., Wang, C., & Xu, Q. (2022) · 癌症:英文版 · doi:10.1002/cac2.12360 · Cited by 132 · see citing works
Glucose Metabolism in Pancreatic Cancer
Liang, Y., Raj, P. S., Yao, W., & Ying, H. (2019) · Cancers · doi:10.3390/cancers11101460 · Cited by 122 · see citing works
SOAT1 promotes mevalonate pathway dependency in pancreatic cancer
Oni, T. E., Biffi, G., Baker, L. A., Yuan, H., Tonelli, C., Somerville, T. D. D., Deschênes, A., Belleau, P., Hwang, C., Rivera, F. J. S., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20192389 · Cited by 124 · see citing works
An Epigenetic Role of Mitochondria in Cancer
Liu, Y., Chen, C., Wang, X., Sun, Y., Zhang, J., Chen, J., & Shi, Y. (2022) · Cells · doi:10.3390/cells11162518 · Cited by 125 · see citing works
BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16
Ma, Q., Zhu, W.-Y., Lu, X., Jiang, D., Xu, F., Li, J., Zhang, L., Wu, Y., Chen, Z., Yin, M., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-021-00520-6 · Cited by 119 · see citing works
Therapeutic resistance of pancreatic cancer: Roadmap to its reversal
Yu, S., Zhang, C., & Xie, K. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188461 · Cited by 117 · see citing works
Lactate is an epigenetic metabolite that drives survival in model systems of glioblastoma
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Cardiolipin, the Mitochondrial Signature Lipid: Implication in Cancer
Pour, S. T. A., Mahéo, K., Servais, S., Brisson, L., & Dumas, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218031 · Cited by 102 · see citing works
Ruze, R., Song, J., Yin, X., Chen, Y., Xu, R., Wang, C., & Zhao, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01376-w · Cited by 103 · see citing works
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Metabolic reprogramming in tumors: Contributions of the tumor microenvironment
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Self-citationEpigenetic regulators in cancer therapy and progression
Marei, H. E. S. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01003-7 · Cited by 101 · see citing works
Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
Franses, J. W., Philipp, J., Missios, P., Bhan, I., Liu, A., Yashaswini, C. N., Tai, E. C., Zhu, H., Ligorio, M., Nicholson, B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17150-3 · Cited by 89 · see citing works
The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy
Ma, Q., Zhang, W., Wu, K., & Shi, L. (2025) · Molecular Cancer · doi:10.1186/s12943-024-02218-1 · Cited by 88 · see citing works
The vital role of ATP citrate lyase in chronic diseases
Khwairakpam, A. D., Banik, K., Girisa, S., Shabnam, B., Shakibaei, M., Fan, L., Arfuso, F., Monisha, J., Wang, H., Mao, X., et al. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01863-0 · Cited by 87 · see citing works
PI3K signaling-regulated metabolic reprogramming: From mechanism to application
Su, W. Y., Tian, L. Y., Guo, L. P., Huang, L., & Gao, W. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188952 · Cited by 83 · see citing works
Mitochondrial Metabolism in PDAC: From Better Knowledge to New Targeting Strategies
Reyes‐Castellanos, G., Masoud, R., & Carrier, A. (2020) · Biomedicines · doi:10.3390/biomedicines8080270 · Cited by 82 · see citing works
Lipid metabolism reprogramming of CD8+ T cell and therapeutic implications in cancer
Wang, R., Liu, Z., Fan, Z., & Zhan, H. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216267 · Cited by 79 · see citing works
ITGA2 promotes expression of ACLY and CCND1 in enhancing breast cancer stemness and metastasis
Adorno-Cruz, V., Hoffmann, A. D., Liu, X., Dashzeveg, N. K., Taftaf, R., Wray, B. D., Keri, R. A., & Liu, H. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.01.015 · Cited by 77 · see citing works
Liu, Q., Ge, W., Wang, T., Lan, J., Martínez‐Jarquín, S., Wolfrum, C., Stoffel, M., & Zenobi, R. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202107223 · Cited by 75 · see citing works
Metabolic determinants of tumour initiation
Brunner, J. S., & Finley, L. W. S. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00773-5 · Cited by 76 · see citing works
Exploring the Role of ATP-Citrate Lyase in the Immune System
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Novel Insights on Lipid Metabolism Alterations in Drug Resistance in Cancer
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Mitochondrial Dysfunction in Aging and Cancer
Moro, L. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111983 · Cited by 73 · see citing works
Biological Networks Regulating Cell Fate Choice are Minimally Frustrated
Tripathi, S., Kessler, D. A., & Levine, H. (2020) · Physical Review Letters · doi:10.1103/physrevlett.125.088101 · Cited by 67 · see citing works
Targeting KRAS: from metabolic regulation to cancer treatment
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Self-citationMetabolic reprogramming and interventions in angiogenesis
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Nutritional Exchanges Within Tumor Microenvironment: Impact for Cancer Aggressiveness
Comito, G., Ippolito, L., Chiarugi, P., & Cirri, P. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00396 · Cited by 61 · see citing works
Unraveling the Anticancer Potential of Statins: Mechanisms and Clinical Significance
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The Bidirectional Relationship Between Cancer Epigenetics and Metabolism
Izzo, L., Affronti, H. C., & Wellen, K. E. (2020) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-070820-035832 · Cited by 60 · see citing works
Self-citationEnhanced Glutaminolysis Drives Hypoxia-Induced Chemoresistance in Pancreatic Cancer
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KRAS mutation: The booster of pancreatic ductal adenocarcinoma transformation and progression
Zhang, Z., Zhang, H., Liao, X., & Tsai, H. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1147676 · Cited by 62 · see citing works
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The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells
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Close interactions between lncRNAs, lipid metabolism and ferroptosis in cancer
Huang, J., Wang, J., He, H., Huang, Z., Wu, S., Chen, C., Liu, W., Xie, L., Tao, Y., Li, C., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.66181 · Cited by 60 · see citing works
ACLY inhibition promotes tumour immunity and suppresses liver cancer
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PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair
Zhang, J., Chen, F., Tian, Y., Xu, W., Zhu, Q., Li, Z., Qiu, L., Lu, X., Peng, B., Liu, X., et al. (2023) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-01107-3 · Cited by 54 · see citing works
The Tricarboxylic Acid Cycle Metabolites for Cancer: Friend or Enemy
Wu, J., Liu, N., Chen, J., Tao, Q., Li, Q., Li, J., Chen, X., & Peng, C. (2024) · Research · doi:10.34133/research.0351 · Cited by 57 · see citing works
Tumor metabolic reprogramming in lung cancer progression (Review)
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Zhou, Z., Ren, Y., Yang, J., Liu, M., Shi, X., Luo, W., Fung, K.-M. A., Xu, C., Bronze, M. S., Zhang, Y., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.06.058 · Cited by 54 · see citing works
Targeting Dysregulated Lipid Metabolism in Cancer with Pharmacological Inhibitors
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Self-citationATP-citrate lyase (ACLY) inhibitors as therapeutic agents: a patenting perspective
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Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer
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Unraveling the intricate relationship between lipid metabolism and oncogenic signaling pathways
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ATF3 induces RAB7 to govern autodegradation in paligenosis, a conserved cell plasticity program
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Cancer metabolism and dietary interventions
Qian, L., Zhang, F., Yin, M., & Lei, Q. (2021) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2021.0461 · Cited by 43 · see citing works
Pancreatic cancer: branched-chain amino acids as putative key metabolic regulators?
Rossmeislová, L., Gojda, J., & Smolková, K. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10016-0 · Cited by 38 · see citing works
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Advances into understanding metabolites as signaling molecules in cancer progression
Liu, J. Y., & Wellen, K. E. (2020) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2020.01.013 · Cited by 37 · see citing works
Self-citationPark, G. S. H., Jung, S., Wellen, K. E., & Jang, C. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00614-x · Cited by 37 · see citing works
Self-citationZhang, H., Li, Y., Huang, J., Shen, L., & Yang, X. W. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.07.021 · Cited by 36 · see citing works
Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment
Zhang, Y., Yang, Z., Liu, Y., Pei, J., Li, R.-J., & Yang, Y. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-024-02426-0 · Cited by 35 · see citing works
Huang, S.-S., Tsai, C., Kuo, C., Li, Y.-S., & Cheng, S. (2022) · Endocrine · doi:10.1007/s12020-022-03124-6 · Cited by 36 · see citing works
Mitophagy’s impacts on cancer and neurodegenerative diseases: implications for future therapies
Huang, J. B., Pham, V. T., Fu, S., Huang, G., Liu, Y., & Zheng, L. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01727-w · Cited by 38 · see citing works
Metabolic Remodeling as a Way of Adapting to Tumor Microenvironment (TME), a Job of Several Holders
Serpa, J. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34025-4_1 · Cited by 34 · see citing works
Mitochondria and CancerPreprint
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Nalbantoğlu, S., & Karadağ, A. (2021) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.114031 · Cited by 34 · see citing works
Yang, J., Ren, B., Ren, J., Yang, G., Fang, Y., Wang, X., Zhou, F., You, L., & Zhao, Y.-P. (2023) · Journal of experimental & clinical cancer research : CR · doi:10.1186/s13046-023-02698-x · Cited by 28 · see citing works
Tumor–stromal metabolic crosstalk in pancreatic cancer
Thakur, R. K., Mullen, N. J., Mehla, K., & Singh, P. K. (2025) · Trends in Cell Biology · doi:10.1016/j.tcb.2025.04.007 · Cited by 33 · see citing works
Parte, S. C., Nimmakayala, R. K., Batra, S. K., & Ponnusamy, M. P. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188669 · Cited by 33 · see citing works
Li, W., Han, J., Huang, B., Xu, T., Wan, Y., Luo, D. L., Kong, W., Yu, Y. H., Zhang, L., Nian, Y., et al. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00369-5 · Cited by 32 · see citing works
Mallick, R., Bhowmik, P., & Duttaroy, A. K. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115591 · Cited by 31 · see citing works
Nucleo-cytosolic acetyl-CoA drives tumor immune evasion by regulating PD-L1 in melanoma
Wang, H., Yi, X., Wang, X., Yang, Y., Zhang, H., Wang, H., Chen, J., Zhang, B., Guo, S., Wu, L., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.115015 · Cited by 31 · see citing works
Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis
Kumar, N., & Mandal, C. C. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.724149 · Cited by 31 · see citing works
- Authors
- Carrer, A., Trefely, S., Zhao, S., Campbell, S. L., Norgard, R. J., Schultz, K. C., Sidoli, S., Parris, J. L. D., Affronti, H. C., Sivanand, S., Egolf, S., Sela, Y., Trizzino, M., Gardini, A., Garcia, B. A., Snyder, N. W., Stanger, B. Z., & Wellen, K. E.
- Affiliations
- University of Pennsylvania (US)
- Drexel University (US)
- The Wistar Institute (US)
- Corresponding author
- Wellen, Kathryn E.
- ORCID
- Venue
- Cancer Discovery
- Published
- 2019-03-01
- Volume
- 9
- Issue
- 3
- Pages
- 416-435
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- PMC
- PMC6643997
- OpenAlex
- W2911157836
- Cited by
- 313
- References
- 76
- Citations by year
- 2026: 23 · 2025: 49 · 2024: 62 · 2023: 47 · 2022: 44 · 2021: 42 · 2020: 31 · 2019: 15
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Update notices
- correction (2024-09-04)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Discovery (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Pancreatic Cancer Action Network (14-20-25-WELL)
- NIH (R01CA174761, R01CA228339, R03HD092630, GM110174, AI118891, CA196539, 1F31CA217070-01, F99CA222741, 4K00CA212455-03)
- American Diabetes Association (#1-18-PDF-144)
- UPenn Baccalaureate Research Education (R25-GM071745)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- acetyl-CoA metabolism, pancreatic ductal adenocarcinoma, pancreatic carcinogenesis, ATP citrate lyase, histone H4 acetylation, acinar-to-ductal metaplasia, KRAS mutation, mevalonate pathway, Akt signaling, BET inhibition, statins, cellular plasticity, epigenetic regulation, pancreatic acinar cells
- MeSH terms
- Acetyl Coenzyme A, Acetylation, Animals, Female, Histones, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Pancreatic Neoplasms, Protein Processing, Post-Translational, Genes, ras, Signal Transduction, Mice, Knockout, Carcinoma, Pancreatic Ductal, Cell Proliferation, Acinar Cells, Carcinogenesis, Heterografts
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