The DOI matches its Crossref record; 257 of the 257 references it cites were found in a registry or an index.
T cell responses in the central nervous system
Open accessAbstract
T cells are required for immune surveillance of the central nervous system (CNS); however, they can also induce severe immunopathology in the context of both viral infections and autoimmunity. The mechanisms that are involved in the priming and recruitment of T cells to the CNS are only partially understood, but there has been renewed interest in this topic since the 'rediscovery' of lymphatic drainage from the CNS. Moreover, tissue-resident memory T cells have been detected in the CNS and are increasingly recognized as an autonomous line of host defence. In this Review, we highlight the main mechanisms that are involved in the priming and CNS recruitment of CD4+ T cells, CD8+ T cells and regulatory T cells. We also consider the plasticity of T cell responses in the CNS, with a focus on viral infection and autoimmunity.
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“CD4+ cells are present in the brain (Korn and Kallies, 2017)”
From Distinct characteristics of hippocampal pathogenic th17 cells in a mouse model of depression (2018) · cites this paper as Korn and Kallies, 2017
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Metadata
- Authors
- Korn, T., & Kallies, A.
- Affiliations
- TUM Klinikum (DE)
- The University of Melbourne (AU)
- Corresponding author
- Korn, Thomas
- Kallies, Axel
- Venue
- Nature Reviews Immunology
- Published
- 2017-01-31
- Volume
- 17
- Issue
- 3
- Pages
- 179-194
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2585996473
- Cited by
- 268
- References
- 257
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 23 · 2023: 26 · 2022: 30 · 2021: 44 · 2020: 29 · 2019: 21 · 2018: 35 · 2017: 19
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- T cell response, central nervous system, regulatory T cells, effector T cells, memory T cells, tissue-resident memory T cells, T cell priming, T cell recruitment, lymphatic drainage, viral infection, autoimmunity, immunopathology, CD4+ T cells, CD8+ T cells, T cell plasticity
- MeSH terms
- Animals, Central Nervous System, Humans, Lymphocyte Activation, Virus Diseases, CD4-Positive T-Lymphocytes, Autoimmunity, CD8-Positive T-Lymphocytes
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