Cited by 268T-cell and B-cell ImmunologyMultiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

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T cell responses in the central nervous system

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Korn, Thomas, Kallies, Axel·2017·Nature Reviews Immunology

DOI 10.1038/nri.2016.144

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Abstract

T cells are required for immune surveillance of the central nervous system (CNS); however, they can also induce severe immunopathology in the context of both viral infections and autoimmunity. The mechanisms that are involved in the priming and recruitment of T cells to the CNS are only partially understood, but there has been renewed interest in this topic since the 'rediscovery' of lymphatic drainage from the CNS. Moreover, tissue-resident memory T cells have been detected in the CNS and are increasingly recognized as an autonomous line of host defence. In this Review, we highlight the main mechanisms that are involved in the priming and CNS recruitment of CD4+ T cells, CD8+ T cells and regulatory T cells. We also consider the plasticity of T cell responses in the CNS, with a focus on viral infection and autoimmunity.

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Authors: Korn, T., & Kallies, A.
Affiliations: TUM Klinikum (DE)
The University of Melbourne (AU)
Corresponding author: Korn, Thomas
Kallies, Axel
ORCID: Korn, Thomas
Kallies, Axel
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2017-01-31
Volume: 17
Issue: 3
Pages: 179-194
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri.2016.144
OpenAlex: W2585996473
Cited by: 268
References: 257
Citations by year: 2026: 16 · 2025: 24 · 2024: 23 · 2023: 26 · 2022: 30 · 2021: 44 · 2020: 29 · 2019: 21 · 2018: 35 · 2017: 19
FWCI: 2.92
Type: journal article
Language: en
Open access: green
zenodo.org
Licence: other-oa
www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: T cell response, central nervous system, regulatory T cells, effector T cells, memory T cells, tissue-resident memory T cells, T cell priming, T cell recruitment, lymphatic drainage, viral infection, autoimmunity, immunopathology, CD4+ T cells, CD8+ T cells, T cell plasticity
MeSH terms: Animals, Central Nervous System, Humans, Lymphocyte Activation, Virus Diseases, CD4-Positive T-Lymphocytes, Autoimmunity, CD8-Positive T-Lymphocytes

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