The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
Heterogeneity in tuberculosis
Open accessAbstract
Infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), results in a range of clinical presentations in humans. Most infections manifest as a clinically asymptomatic, contained state that is termed latent TB infection (LTBI); a smaller subset of infected individuals present with symptomatic, active TB. Within these two seemingly binary states, there is a spectrum of host outcomes that have varying symptoms, microbiologies, immune responses and pathologies. Recently, it has become apparent that there is diversity of infection even within a single individual. A good understanding of the heterogeneity that is intrinsic to TB — at both the population level and the individual level — is crucial to inform the development of intervention strategies that account for and target the unique, complex and independent nature of the local host–pathogen interactions that occur in this infection. In this Review, we draw on model systems and human data to discuss multiple facets of TB biology and their relationship to the overall heterogeneity observed in the human disease.
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Cites
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Self-citationThe Immune Response in Tuberculosis
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Cited by
Ecology and evolution of Mycobacterium tuberculosis
Gagneux, S. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2018.8 · Cited by 599
Drain, P. K., Bajema, K. L., Dowdy, D., Dheda, K., Naidoo, K., Schumacher, S. G., Ma, S., Meermeier, E., Lewinsohn, D. M., & Sherman, D. R. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00021-18 · Cited by 565
Anti-tuberculosis treatment strategies and drug development: challenges and priorities
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Immunology of Mycobacterium tuberculosis Infections
Sia, J. K., & Rengarajan, J. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0022-2018 · Cited by 312
The immunoregulatory landscape of human tuberculosis granulomas
McCaffrey, E. F., Donato, M., Keren, L., Chen, Z., Delmastro, A., Fitzpatrick, M. B., Gupta, S., Greenwald, N. F., Baranski, A., Graf, W., et al. (2022) · Nature Immunology · doi:10.1038/s41590-021-01121-x · Cited by 304
Metadata
- Authors
- Cadena, A. M., Fortune, S. M., & Flynn, J. L.
- Venue
- Nature Reviews Immunology
- Published
- 2017-07-24
- Volume
- 17
- Issue
- 11
- Pages
- 691-702
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2737860676
- Cited by
- 484
- References
- 129
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- green
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