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MHC class I molecules and kirs in human history, health and survival
Abstract
MHC class I molecules are ligands for the killer-cell immunoglobulin-like receptors (KIRs), which are expressed by natural killer cells and T cells. The interactions between these molecules contribute to both innate and adaptive immunity. KIRs and MHC class I molecules are encoded by unlinked polymorphic gene families that distinguish all but the most related individuals. Combinations of MHC class I and KIR variants influence resistance to infections, susceptibility to autoimmune diseases and complications of pregnancy, as well as outcome after haematopoietic stem-cell transplantation. Such correlations raise the possibility that interplay between KIR and MHC class I polymorphisms has facilitated human survival in the presence of epidemic infections and has influenced both reproduction and population growth.
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“Similarly significant differences were seen following genotyping of the mothers, suggesting a broad influence of the genetic background of NK activity, especially given that KIR/HLA complexes are expressed and active in the placenta (Guerini et al, 2014;Parham, 2005).”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Parham, 2005
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Metadata
- Authors
- Parham, P.
- Affiliations
- Stanford University (US)
- Corresponding author
- Parham, Peter
- ORCID
- Parham, Peter
- Venue
- Nature Reviews Immunology
- Published
- 2005-02-18
- Volume
- 5
- Issue
- 3
- Pages
- 201-214
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2008919922
- Cited by
- 1,203
- References
- 125
- Citations by year
- 2026: 28 · 2025: 36 · 2024: 35 · 2023: 23 · 2022: 44 · 2021: 38 · 2020: 43 · 2019: 54 · 2018: 46 · 2017: 50 · 2016: 57 · 2015: 55 · 2014: 57 · 2013: 95 · 2012: 77
- FWCI
- 5.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- MHC class I, killer cell immunoglobulin-like receptors, natural killer cells, T cells, infection resistance, autoimmune disease susceptibility, pregnancy complications, hematopoietic stem cell transplantation, human survival, immune system evolution, reproduction
- MeSH terms
- Animals, Autoimmune Diseases, Communicable Diseases, Humans, Lymphocytes, Neoplasms, Receptors, Immunologic, Histocompatibility Antigens Class I, Models, Immunological, Evolution, Molecular, Receptors, KIR
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