The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
MHC class I molecules and kirs in human history, health and survival
Abstract
MHC class I molecules are ligands for the killer-cell immunoglobulin-like receptors (KIRs), which are expressed by natural killer cells and T cells. The interactions between these molecules contribute to both innate and adaptive immunity. KIRs and MHC class I molecules are encoded by unlinked polymorphic gene families that distinguish all but the most related individuals. Combinations of MHC class I and KIR variants influence resistance to infections, susceptibility to autoimmune diseases and complications of pregnancy, as well as outcome after haematopoietic stem-cell transplantation. Such correlations raise the possibility that interplay between KIR and MHC class I polymorphisms has facilitated human survival in the presence of epidemic infections and has influenced both reproduction and population growth.
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“Similarly significant differences were seen following genotyping of the mothers, suggesting a broad influence of the genetic background of NK activity, especially given that KIR/HLA complexes are expressed and active in the placenta (Guerini et al, 2014;Parham, 2005).”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Parham, 2005
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Cites
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Natural killer cells and pregnancy
Moffett-King, A. (2002) · Nature Reviews Immunology · doi:10.1038/nri886 · Cited by 1,235
HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection
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Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
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Human Diversity in Killer Cell Inhibitory Receptor Genes
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Self-citationKIR: Diverse, Rapidly Evolving Receptors of Innate and Adaptive Immunity
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Self-citationAshkar, A. A., Santo, J. P. D., & Croy, B. A. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.259 · Cited by 847
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Functions of natural killer cells
Vivier, E., Tomasello, E., Baratin, M., Walzer, T., & Ugolini, S. (2008) · Nature Immunology · doi:10.1038/ni1582 · Cited by 3,943
Innate or adaptive immunity? The example of natural killer cells
Vivier, E., Raulet, D. H., Moretta, A., Caligiuri, M. A., Zitvogel, L., Lanier, L. L., Yokoyama, W. M., & Ugolini, S. (2011) · Science · doi:10.1126/science.1198687 · Cited by 2,824
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Human NK Cell Education by Inhibitory Receptors for MHC Class I
Anfossi, N., André, P., Guia, S., Falk, C. S., Roetynck, S., Stewart, C. A., Breso, V., Frassati, C., Reviron, D., Middleton, D., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.013 · Cited by 1,207
Metadata
- Authors
- Parham, P.
- Affiliations
- Stanford University (US)
- Corresponding author
- Parham, Peter
- ORCID
- Parham, Peter
- Venue
- Nature Reviews Immunology
- Published
- 2005-02-18
- Volume
- 5
- Issue
- 3
- Pages
- 201-214
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2008919922
- Cited by
- 1,203
- References
- 125
- Citations by year
- 2026: 28 · 2025: 36 · 2024: 35 · 2023: 23 · 2022: 44 · 2021: 38 · 2020: 43 · 2019: 54 · 2018: 46 · 2017: 50 · 2016: 57 · 2015: 55 · 2014: 57 · 2013: 95 · 2012: 77
- FWCI
- 5.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- MHC class I, killer cell immunoglobulin-like receptors, natural killer cells, T cells, infection resistance, autoimmune disease susceptibility, pregnancy complications, hematopoietic stem cell transplantation, human survival, immune system evolution, reproduction
- MeSH terms
- Animals, Autoimmune Diseases, Communicable Diseases, Humans, Lymphocytes, Neoplasms, Receptors, Immunologic, Histocompatibility Antigens Class I, Models, Immunological, Evolution, Molecular, Receptors, KIR
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