The DOI matches its Crossref record; 124 of the 126 references it cites were found in a registry or an index.
Regulation of immune cells by local-tissue oxygen tension: HIF1α and adenosine receptors
Abstract
Immune cells are often exposed to low oxygen tensions, which markedly affect cellular metabolism. We describe how activated T cells adapt to the changing energy supplies in hypoxic areas of inflamed tissues by using hypoxia-inducible factor 1 (HIF1) to switch to glycolysis as the main source of energy and by signalling through extracellular-adenosine receptors. This hypoxic regulation might alter the balance between T helper 1 cells and T helper 2 cells and might alter the activities of cells of the innate immune system, thereby qualitatively and quantitatively affecting immune responses. This regulatory mechanism should be taken into account in the design and interpretation of in vitro and in vivo studies of immune-cell effector functions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Co-expressed with Mac-1 components, the hypoxia-inducible factor 1 (HIF1A) is a well characterized transcription factor that performs an essential role in cellular responses to hypoxia. HIF1A is also involved in the regulation of macrophage migration, and modulates the metabolism of immune cells exposed to low oxygen tensions in hypoxic areas of inflamed tissues [30].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [30]
Citations
Cites
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 1×
“, a process that provides long-term T-cell memory and ensures the rapid production of cytokines on subsequent interaction with the pathoge”
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981
On Respiratory Impairment in Cancer Cells
Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472
Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333
Babior, B. M., Kipnes, R. S., & Curnutte, J. T. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107236 · Cited by 2,931
Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617
Flagged first, then by citations
2 of the 126 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Winn, H. R., Rubio, R., Curnish, R. R. & Berne, R. M. Changes in regional cerebral blood flow (rCBF) caused by increase in CSF concentrations of adenosine and 2-chloroadenosine (CHL-ADO). J. Cereb. Blood Flow Metab. 1, S401–S402 (1981).
- Richard, D. E., Berra, E. & Pouyssegur, J. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1α in vascular smooth muscle cells. J. Biol. Chem. 275, 26765–26771 (2000). · DOI
Cited by
Sorted by citations
Items 501–517 of 517
Additional file 1 of The effect of hypoxia on PD-L1 expression in bladder cancer
Smith, V., Mukherjee, D., Lunj, S., Choudhury, A., Hoskin, P., West, C., & Illidge, T. (2021) · Figshare · doi:10.6084/m9.figshare.17079367
de Buhr, N., Martens, A., Meurer, M., Bonilla, M. C., Söbbeler, F., Twele, L., Neudeck, S., Wendt, M., Beineke, A., Kästner, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14870318
Additional file 6 of The effect of hypoxia on PD-L1 expression in bladder cancer
Smith, V., Mukherjee, D., Lunj, S., Choudhury, A., Hoskin, P., West, C., & Illidge, T. (2021) · Figshare · doi:10.6084/m9.figshare.17079382
Wang, W., Zheng, Y., Wu, Z., Wu, M., Chen, Y., Zhang, Y., Fu, S., & Wu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26308940
de Buhr, N., Martens, A., Meurer, M., Bonilla, M. C., Söbbeler, F., Twele, L., Neudeck, S., Wendt, M., Beineke, A., Kästner, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14870330
de Buhr, N., Martens, A., Meurer, M., Bonilla, M. C., Söbbeler, F., Twele, L., Neudeck, S., Wendt, M., Beineke, A., Kästner, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14870324
Additional file 2 of The effect of hypoxia on PD-L1 expression in bladder cancer
Smith, V., Mukherjee, D., Lunj, S., Choudhury, A., Hoskin, P., West, C., & Illidge, T. (2021) · Figshare · doi:10.6084/m9.figshare.17079370
Additional file 3 of The effect of hypoxia on PD-L1 expression in bladder cancer
Smith, V., Mukherjee, D., Lunj, S., Choudhury, A., Hoskin, P., West, C., & Illidge, T. (2021) · Figshare · doi:10.6084/m9.figshare.17079373
de Buhr, N., Martens, A., Meurer, M., Bonilla, M. C., Söbbeler, F., Twele, L., Neudeck, S., Wendt, M., Beineke, A., Kästner, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14870333
ROLE OF HIF-1 SIGNALING PATHWAY IN CELLULAR ADAPTATION TO HYPOXIA
Borysewicz, K., Koval, I., Kubik, W., Czarnecki, B., Nowak, J., Kujawa, B., Zwoliński, B., Sukiennicki, K., Bertman, W., Kołdej, N., et al. (2025) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.4(48).2025.4299
Li, L., Kan, S., Huang, Q., Wang, S., Han, Y., Chen, L., & Jin, S. J. (2026) · Phenomics · doi:10.1007/s43657-025-00309-7
Sun, S., Meng, B., Sang, J., Liu, W., Zhang, Y., Li, D., Li, D., Zhang, P., Niu, J., Wei, J., et al. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s595375
Capó, X., Torrens‐Mas, M., Calvo-Navarrete, G., Gill, F., Raimundo, A., Saunter, C. D., Carretero, A., Navas-Enamorado, C., de la Llave, A. M., Sánchez-Polo, A., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.06.034
Ghosh, S., Devereaux, M. W., Orlicky, D. J., Kasmi, K. C. E., & Sokol, R. J. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168410
Effects of Tumor Microenvironment on Immunity and Consequent Clinical Considerations
Baronzio, G., Freitas, I., Fiorentini, G., Crugnola, A. R., Hager, E. D., Ceppodomo, D., & Kiselevsky, M. V. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9576-4_9
Metadata
- Authors
- Sitkovsky, M., & Lukashev, D.
- Affiliations
- Northeastern University (US)
- Corresponding author
- Sitkovsky, Michail
- ORCID
- Sitkovsky, Michail
- Venue
- Nature Reviews Immunology
- Published
- 2005-08-19
- Volume
- 5
- Issue
- 9
- Pages
- 712-721
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2089916504
- Semantic Scholar
- 86ac33e3809727856e079e987663bd86cf83fd9d
- Cited by
- 518
- References
- 126
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 17 · 2023: 15 · 2022: 14 · 2021: 37 · 2020: 29 · 2019: 18 · 2018: 23 · 2017: 23 · 2016: 21 · 2015: 17 · 2014: 32 · 2013: 38 · 2012: 41
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- hypoxia, tissue oxygen tension, HIF-1α, adenosine receptors, T cell metabolism, glycolysis, inflammation, innate immune cells, immune cell regulation, energy metabolism
- MeSH terms
- Animals, T-Lymphocytes, Helper-Inducer, Humans, Oxygen, Partial Pressure, Transcription Factors, Receptors, Purinergic P1, Hypoxia-Inducible Factor 1, alpha Subunit
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
