The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Statin therapy and autoimmune disease: from protein prenylation to immunomodulation
Open accessAbstract
Statins have been prescribed extensively for their cholesterol-lowering properties and efficacy in cardiovascular disease. However, compelling evidence now exists that statins also have extensive immunomodulatory properties that operate independently of lipid lowering. Consequently, much attention has been directed towards their potential as therapeutic agents for the treatment of autoimmune disease. Modulation of post-translational protein prenylation seems to be a key mechanism by which statins alter immune function. In this Review, the effect of statin therapy on immune function, and how this relates to the pathogenesis of autoimmune disease, is reviewed alongside current opinion of what the key biological targets of statins are.
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Self-citationProgressive multiple sclerosis: from pathophysiology to therapeutic strategies
Faissner, S., Plemel, J. R., Gold, R., & Yong, V. W. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0035-2 · Cited by 459
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Metadata
- Authors
- Greenwood, J., Steinman, L., & Zamvil, S. S.
- Venue
- Nature Reviews Immunology
- Published
- 2006-05
- Volume
- 6
- Issue
- 5
- Pages
- 358-370
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2072318687
- Cited by
- 683
- References
- 105
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
