Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system
Abstract
Adhesion molecules of the immunoglobulin superfamily are crucial effectors of leukocyte trafficking into the central nervous system. Using a lipid raft-based proteomic approach, we identified ALCAM as an adhesion molecule involved in leukocyte migration across the blood-brain barrier (BBB). ALCAM expressed on BBB endothelium localized together with CD6 on leukocytes and with BBB endothelium transmigratory cups. ALCAM expression on BBB cells was upregulated in active multiple sclerosis and experimental autoimmune encephalomyelitis lesions. Moreover, ALCAM blockade restricted the transmigration of CD4+ lymphocytes and monocytes across BBB endothelium in vitro and in vivo and reduced the severity and delayed the time of onset of experimental autoimmune encephalomyelitis. Our findings indicate an important function for ALCAM in the recruitment of leukocytes into the brain and identify ALCAM as a potential target for the therapeutic dampening of neuroinflammation.
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Activated leukocyte cell adhesion molecule (CD166) can foster diapedesis of monocytes and, to a lesser extent, CD4 T cells during EAE.
“Activated leukocyte cell adhesion molecule (CD166) can also foster diapedesis of monocytes and, to a lesser extent, CD4 T cells during EAE (111, 112).”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [112]
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- Authors
- Cayrol, R., Wosik, K., Berard, J. L., Dodelet-Devillers, A., Ifergan, I., Kebir, H., Haqqani, A. S., Kreymborg, K., Krug, S., Moumdjian, R., Bouthillier, A., Becher, B., Arbour, N., David, S., Stanimirovic, D., & Prat, A.
- Affiliations
- Hôpital Notre-Dame (CA)
- McGill University Health Centre (CA)
- Institute for Biological Sciences (CA)
- University of Zurich (CH)
- Corresponding author
- Prat, Alexandre
- ORCID
- Venue
- Nature Immunology
- Published
- 2007-12-23
- Volume
- 9
- Issue
- 2
- Pages
- 137-145
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2098345971
- Cited by
- 444
- References
- 49
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 17 · 2023: 15 · 2022: 29 · 2021: 20 · 2020: 31 · 2019: 24 · 2018: 13 · 2017: 26 · 2016: 17 · 2015: 35 · 2014: 20 · 2013: 27 · 2012: 29
- FWCI
- 16.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- NPARC (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- ALCAM, leukocyte migration, blood-brain barrier, leukocyte transmigration, CD6, multiple sclerosis, experimental autoimmune encephalomyelitis, neuroinflammation, immunoglobulin superfamily adhesion molecules, CD4+ T cells, monocytes, lipid rafts
- MeSH terms
- Blood-Brain Barrier, Brain, Cell Movement, Cells, Cultured, Encephalomyelitis, Autoimmune, Experimental, Humans, CD4-Positive T-Lymphocytes, Activated-Leukocyte Cell Adhesion Molecule, Membrane Microdomains, Proteomics
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