Cited by 2,022Cell Adhesion Molecules ResearchAngiogenesis and VEGF in CancerNitric Oxide and Endothelin Effects

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Evolving functions of endothelial cells in inflammation

Pober, Jordan S., Sessa, William C.·2007·Nature Reviews Immunology

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Abstract

Inflammation is usually analysed from the perspective of tissue-infiltrating leukocytes. Microvascular endothelial cells at a site of inflammation are both active participants in and regulators of inflammatory processes. The properties of endothelial cells change during the transition from acute to chronic inflammation and during the transition from innate to adaptive immunity. Mediators that act on endothelial cells also act on leukocytes and vice versa. Consequently, many anti-inflammatory therapies influence the behaviour of endothelial cells and vascular therapeutics influence inflammation. This Review describes the functions performed by endothelial cells at each stage of the inflammatory process, emphasizing the principal mediators and signalling pathways involved and the therapeutic implications.

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Arnout, J., Hoylaerts, M. F. & Lijnen, H. R. Haemostasis. Handb. Exp. Physiol. 176, 1–42 (2006).
Pober, J. S. in The Endothelium: A Comprehensive Reference (ed. Aird, W. C.) (Cambrigde Univ. Press, Cambridge, in the press).

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Authors: Pober, J. S., & Sessa, W. C.
Affiliations: Yale University (US)
Corresponding author: Pober, Jordan S.
ORCID: Pober, Jordan S.
Sessa, William C.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2007-10
Volume: 7
Issue: 10
Pages: 803-815
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2171
OpenAlex: W2171783221
Cited by: 2,022
References: 99
Citations by year: 2026: 147 · 2025: 138 · 2024: 163 · 2023: 138 · 2022: 185 · 2021: 194 · 2020: 151 · 2019: 100 · 2018: 104 · 2017: 120 · 2016: 75 · 2015: 100 · 2014: 78 · 2013: 74 · 2012: 77
FWCI: 3.57
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: endothelial cells, inflammation, acute and chronic inflammation, leukocyte-endothelium interaction, vascular inflammation, anti-inflammatory therapy, inflammatory mediators
MeSH terms: Animals, Anti-Inflammatory Agents, Communicable Diseases, Histamine, Humans, Inflammation, Wounds and Injuries, Signal Transduction, Cytokines, Endothelial Cells

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