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Evolving functions of endothelial cells in inflammation
Abstract
Inflammation is usually analysed from the perspective of tissue-infiltrating leukocytes. Microvascular endothelial cells at a site of inflammation are both active participants in and regulators of inflammatory processes. The properties of endothelial cells change during the transition from acute to chronic inflammation and during the transition from innate to adaptive immunity. Mediators that act on endothelial cells also act on leukocytes and vice versa. Consequently, many anti-inflammatory therapies influence the behaviour of endothelial cells and vascular therapeutics influence inflammation. This Review describes the functions performed by endothelial cells at each stage of the inflammatory process, emphasizing the principal mediators and signalling pathways involved and the therapeutic implications.
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“A burst in the generation of proinflammatory agents, as a part of an overwhelmed host response, contributes to endothelial barrier breakdown in these diseases, promoting shock and multiorgan failure in patients (1, 2).”
From Targeting β1-integrin inhibits vascular leakage in endotoxemia (2018) · cites this paper as [1]
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“However, immune functions are not unique to hematopoietic cells, and many other cell types display basic mechanisms of pathogen defence3–5.”
From Structural cells are key regulators of organ-specific immune responses (2020) · cites this paper as [4]
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Metadata
- Authors
- Pober, J. S., & Sessa, W. C.
- Affiliations
- Yale University (US)
- Corresponding author
- Pober, Jordan S.
- Venue
- Nature Reviews Immunology
- Published
- 2007-10
- Volume
- 7
- Issue
- 10
- Pages
- 803-815
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2171783221
- Cited by
- 2,022
- References
- 99
- Citations by year
- 2026: 147 · 2025: 138 · 2024: 163 · 2023: 138 · 2022: 185 · 2021: 194 · 2020: 151 · 2019: 100 · 2018: 104 · 2017: 120 · 2016: 75 · 2015: 100 · 2014: 78 · 2013: 74 · 2012: 77
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- endothelial cells, inflammation, acute and chronic inflammation, leukocyte-endothelium interaction, vascular inflammation, anti-inflammatory therapy, inflammatory mediators
- MeSH terms
- Animals, Anti-Inflammatory Agents, Communicable Diseases, Histamine, Humans, Inflammation, Wounds and Injuries, Signal Transduction, Cytokines, Endothelial Cells
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