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Cited by 225Ion Channels and ReceptorsCalcium signaling and nucleotide metabolismIon channel regulation and function

Calcium signalling and cell-fate choice in B cells

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Scharenberg, Andrew M., Humphries, Lisa A., Rawlings, David J.·2007·Nature Reviews Immunology
DOI 10.1038/nri2172PMC PMC2743935
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Abstract

Alterations in the cytosolic concentration of calcium ions (Ca2+) transmit information that is crucial for the development and function of B cells. Cytosolic Ca2+ concentration is determined by a balance of active transport and gradient-driven Ca2+ fluxes, both of which are subject to the influence of multiple receptors and environmental sensing pathways. Recent advances in genomics have allowed for the compilation of an increasingly comprehensive list of Ca2+ transporters and channels expressed by B cells. The increasing understanding of the function and regulation of these proteins has begun to shift the frontier of Ca2+ physiology in B cells from molecular analysis to determining how diverse inputs to cytosolic Ca2+ concentration are integrated in specific immunological contexts.

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  • Anti-IgM antibodies stimulate B cells through the B cell receptor (BCR) thereby activating downstream signaling cascades like PI3K, AKT and MAPK pathways.

    “Anti-IgM antibodies stimulate B cells through the B cell receptor (BCR) thereby activating further downstream signaling cascades like the phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT) and mitogen-activated protein kinase (MAPK) pathways [51–53].”

    From The oncoprotein TBX3 is controlling severity in experimental arthritis (2019) · cites this paper as [51]

    The Introduction describes BCR engagement activating a signalling complex and identifies PI3K as part of BCR signalling. It does not establish that anti-IgM antibodies activate the claimed AKT and MAPK pathways; MAPK appears only in the title of a cited reference. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Scharenberg, A. M., Humphries, L. A., & Rawlings, D. J.
Affiliations
Seattle Children's Hospital (US)
Corresponding author
  • Scharenberg, Andrew M.
  • Rawlings, David J.
ORCID
Venue
Nature Reviews Immunology
Publisher
Springer Science and Business Media LLC
Published
2007-10
Volume
7
Issue
10
Pages
778-789
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
DOI
10.1038/nri2172
PMC
PMC2743935
OpenAlex
W2011593699
Cited by
225
References
3
Citations by year
2026: 4 · 2025: 6 · 2024: 10 · 2023: 9 · 2022: 15 · 2021: 13 · 2020: 15 · 2019: 10 · 2018: 7 · 2017: 12 · 2016: 15 · 2015: 12 · 2014: 9 · 2013: 6 · 2012: 17
FWCI
1.44
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (HL07543)
  • National Cancer Institute (R01CA081140, CA 81140)
  • National Institute of General Medical Sciences (R01GM064091, P01GM078195, R01GM064316, GM64316, GM64091)
  • National Institute of Allergy and Infectious Diseases (AI45901, AI044259, R01AI044259, R01AI045901)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD37091, R01HD037091)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords
calcium signaling, B cells, intracellular calcium, cell fate determination, calcium transporters, calcium channels, calcium flux, calcium homeostasis, B cell development, B cell function, signal integration
MeSH terms
Animals, B-Lymphocytes, Calcium, Cytosol, Humans, Receptors, Antigen, B-Cell, Inositol 1,4,5-Trisphosphate, Calcium Signaling, Phospholipase C gamma

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