The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Annexin A1 and glucocorticoids as effectors of the resolution of inflammation
Abstract
Glucocorticoids are widely used for the management of inflammatory diseases. Their clinical application stems from our understanding of the inhibitory effect of the corticosteroid hormone cortisol on several components of the immune system. Endogenous and exogenous glucocorticoids mediate their multiple anti-inflammatory effects through many effector molecules. In this Opinion article, we focus on the role of one such effector molecule, annexin A1, and summarize the recent studies that provide insight into its molecular and pharmacological functions in immune responses. In addition, we propose a model in which glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation.
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“By activating cell-surface receptors, pro-resolving mediators block inflammatory cell influx and promote the egress of inflammatory cells, modulate pro-inflammatory T cell responses and promote clearance of both pathogens and dead cells (efferocytosis), with all these functions serving to limit tissue damage and to enable the repair of injured tissue29,30.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [30]
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Cites
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
Rhen, T., & Cidlowski, J. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050541 · Cited by 3,149
Resolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552
Annexins: linking Ca2+ signalling to membrane dynamics
Gerke, V., Creutz, C. E., & Moss, S. E. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1661 · Cited by 1,412
Resolution of in flammation: state of the art, definitions and terms
Serhan, C. N., Brain, S. D., Buckley, C. D., Gilroy, D. W., Haslett, C., O'Neill, L. A. J., Perretti, M., Rossi, A. G., & Wallace, J. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-7227rev · Cited by 1,045 · cited 1×
“The concept that inflammation is resolved in a time- and space-specific manner is emerging, such that different outcomes can be produced according to the stage or site at which a given pathway or mediator becomes operativ”
BackgroundSelf-citationPromotion of Tissue Inflammation by the Immune Receptor Tim-3 Expressed on Innate Immune Cells
Anderson, A. C., Anderson, D. E., Bregoli, L., Hastings, W. D., Kassam, N., Lei, C., Chandwaskar, R., Kármán, J., Su, E. W., Hirashima, M., et al. (2007) · Science · doi:10.1126/science.1148536 · Cited by 703
Ito, K., Yamamura, S., Essilfie-Quaye, S., Cosio, B., Ito, M., Barnes, P. J., & Adcock, I. M. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050466 · Cited by 638
Glucocorticoids and the Th1/Th2 Balance
Elenkov, I. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.010 · Cited by 618
Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro
Ramírez, F., Fowell, D. J., Puklavec, M. J., Simmonds, S. J., & Mason, D. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.7.2406 · Cited by 483
The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo
Chiang, N., Serhan, C. N., Dahlén, S., Drazen, J. M., Hay, D. W. P., Rovati, G. E., Shimizu, T., Yokomizo, T., & Brink, C. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.4 · Cited by 464
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Colditz, I. G. (2026) · Peer Community Journal · doi:10.24072/pcjournal.808
Xie, F., Sun, Y., Wei, X., Zhang, W., Luo, W., Huang, J., Fang, S., Zhang, X., Qiu, H., & Chao, J. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3274-2
Shared Transcriptomic Signatures and Network Interactions Between Lung Adenocarcinoma and Asthma
Akduman, S., Düz, E., GÜNDOĞDU, M., Tecimel, D., Dalan, A. B., Bayrak, Ö. F., & Seven, D. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27125544
The landscape of serum autoantibodies in lupus nephritis
Bruschi, M., Alberici, F., Moroni, G. L., Vaglio, A., Sinico, R. A., Franceschini, F., Fredi, M., Porta, E. L., Calatroni, M., Cavagna, L., et al. (2026) · Autoimmunity Reviews · doi:10.1016/j.autrev.2026.104128
Mohammed, E. T., Kandeil, M. A., Gad, O. I., Abd-Elrahman, A. M., & Hassan, E. M. (2026) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-026-00794-3
Premarathna, A. D., Dziubińska‐Kühn, K., Saravanan, M., Sooäär, A., Reile, I., Ahmed, T. A., Hincke, M. T., & Tuvikene, R. (2026) · Marine Drugs · doi:10.3390/md24090299
van Bruggen, V. L. E., Claassen, S. J. C. M., Klein, L., Bokobza, C., Hua, J., Marvillet, T., Zandbergen, M. M. E., van Gorp, C., Caimant, F., van der Molen, R. G., et al. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101359
Prognostic Significance of Tumor Budding, Tumor–Stroma Ratio, and Annexin A1 in Gallbladder Cancer
Choi, S.-E., Lee, J. H., & Kim, E. K. (2026) · International Journal of Surgical Pathology · doi:10.1177/10668969261470846
Bruggink, V., Gutjahr, C., Werner, M., Kralisch, D., Werz, O., & Hofstetter, R. K. (2026) · Journal of Ginseng Research · doi:10.1016/j.jgr.2026.101159
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Ory, L., Nasello, G., Borgiani, E., Verbraeken, T., Bosmans, K., Geeroms, C., Hoven, I. V., Nefyodova, E., Chabot, C., Geris, L., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.25.754061
Yazdi, R. F., Tan, S. I., Bu, W., FRANCO, B. B., Ng, A. J. K., Peh, H. Y., & Chen, J. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.109655
Subramanian, M. (2026) · Current topics in microbiology and immunology · doi:10.1007/82_2026_361
Serhan, C. N. (2026) · Current topics in microbiology and immunology · doi:10.1007/82_2026_354
Yang, T., LIU, W., Wang, H., Wu, Y., Ma, Y., Wang, X., Lei, T., Tang, Q., Zhou, Y., Li, W., et al. (2026) · Advanced Science · doi:10.1002/advs.78321
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Norbo‘tayev, O., Abdurahmanova, N., & Mirzayev, O. (2025) · Eurasian Journal of Medical and Natural Sciences · doi:10.70413/ejmns-v05-i08-s11130
Su, X., Li, L., Han, W., & Hao, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1976748
Song, X., Che, D., Peng, B., Huang, X., Zhou, T., Li, R., Zeng, W., & Geng, S. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117608
Rethinking inflammaging: Spatiotemporal decoupling and the failure of inflammatory regulation
Deng, X., Wang, L., Luo, M., & Wu, J. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103438
Modulation fonctionnelle des cellules dendritiques par les « Neutrophil Extracellular Traps »
Barrientos, L. (2013) · theses.fr (ABES) · doi:10.70675/d74489c5z4048z43e4za7ebz0dd46aa98d1b
Metadata
- Authors
- Perretti, M., & D'Acquisto, F.
- Affiliations
- Queen Mary University of London (GB)
- Corresponding author
- Perretti, Mauro
- ORCID
- Perretti, Mauro
- Venue
- Nature Reviews Immunology
- Published
- 2009-01
- Volume
- 9
- Issue
- 1
- Pages
- 62-70
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2128864178
- Cited by
- 915
- References
- 84
- Citations by year
- 2026: 38 · 2025: 45 · 2024: 43 · 2023: 57 · 2022: 68 · 2021: 89 · 2020: 57 · 2019: 58 · 2018: 43 · 2017: 47 · 2016: 54 · 2015: 53 · 2014: 46 · 2013: 60 · 2012: 51
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- British Heart Foundation
- Versus Arthritis
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Keywords
- annexin A1, glucocorticoids, inflammation resolution, anti-inflammatory activity, cortisol, innate immune cells, adaptive immune cells
- MeSH terms
- Animals, Anti-Inflammatory Agents, Circadian Rhythm, Gene Expression Regulation, Glucocorticoids, Humans, Hydrocortisone, Immune System, Immunity, Innate, Inflammation, Macrophages, Monocytes, Neutrophils, T-Lymphocyte Subsets, Annexin A1, Mice, Knockout, Models, Immunological, Receptors, Formyl Peptide, Lipoxins, Receptors, Lipoxin, Mice
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