The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Annexin A1 and glucocorticoids as effectors of the resolution of inflammation
Abstract
Glucocorticoids are widely used for the management of inflammatory diseases. Their clinical application stems from our understanding of the inhibitory effect of the corticosteroid hormone cortisol on several components of the immune system. Endogenous and exogenous glucocorticoids mediate their multiple anti-inflammatory effects through many effector molecules. In this Opinion article, we focus on the role of one such effector molecule, annexin A1, and summarize the recent studies that provide insight into its molecular and pharmacological functions in immune responses. In addition, we propose a model in which glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation.
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“By activating cell-surface receptors, pro-resolving mediators block inflammatory cell influx and promote the egress of inflammatory cells, modulate pro-inflammatory T cell responses and promote clearance of both pathogens and dead cells (efferocytosis), with all these functions serving to limit tissue damage and to enable the repair of injured tissue29,30.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [30]
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Annexins: linking Ca2+ signalling to membrane dynamics
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Resolution of in flammation: state of the art, definitions and terms
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“The concept that inflammation is resolved in a time- and space-specific manner is emerging, such that different outcomes can be produced according to the stage or site at which a given pathway or mediator becomes operativ”
BackgroundSelf-citationPromotion of Tissue Inflammation by the Immune Receptor Tim-3 Expressed on Innate Immune Cells
Anderson, A. C., Anderson, D. E., Bregoli, L., Hastings, W. D., Kassam, N., Lei, C., Chandwaskar, R., Kármán, J., Su, E. W., Hirashima, M., et al. (2007) · Science · doi:10.1126/science.1148536 · Cited by 703
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Glucocorticoids and the Th1/Th2 Balance
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Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro
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The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo
Chiang, N., Serhan, C. N., Dahlén, S., Drazen, J. M., Hay, D. W. P., Rovati, G. E., Shimizu, T., Yokomizo, T., & Brink, C. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.4 · Cited by 464
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Immunogenic cell death in cancer and infectious disease
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Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341
Metadata
- Authors
- Perretti, M., & D'Acquisto, F.
- Affiliations
- Queen Mary University of London (GB)
- Corresponding author
- Perretti, Mauro
- ORCID
- Perretti, Mauro
- Venue
- Nature Reviews Immunology
- Published
- 2009-01
- Volume
- 9
- Issue
- 1
- Pages
- 62-70
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2128864178
- Cited by
- 915
- References
- 84
- Citations by year
- 2026: 38 · 2025: 45 · 2024: 43 · 2023: 57 · 2022: 68 · 2021: 89 · 2020: 57 · 2019: 58 · 2018: 43 · 2017: 47 · 2016: 54 · 2015: 53 · 2014: 46 · 2013: 60 · 2012: 51
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- British Heart Foundation
- Versus Arthritis
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Keywords
- annexin A1, glucocorticoids, inflammation resolution, anti-inflammatory activity, cortisol, innate immune cells, adaptive immune cells
- MeSH terms
- Animals, Anti-Inflammatory Agents, Circadian Rhythm, Gene Expression Regulation, Glucocorticoids, Humans, Hydrocortisone, Immune System, Immunity, Innate, Inflammation, Macrophages, Monocytes, Neutrophils, T-Lymphocyte Subsets, Annexin A1, Mice, Knockout, Models, Immunological, Receptors, Formyl Peptide, Lipoxins, Receptors, Lipoxin, Mice
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