The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
B-cell responses to vaccination at the extremes of age
Open accessAbstract
Infants and the elderly share a high vulnerability to infections and therefore have specific immunization requirements. Inducing potent and sustained B-cell responses is as challenging in infants as it is in older subjects. Several mechanisms to explain the decreased B-cell responses at the extremes of age apply to both infants and the elderly. These include intrinsic B-cell limitations as well as numerous microenvironmental factors in lymphoid organs and the bone marrow. This Review describes the mechanisms that shape B-cell responses at the extremes of age and how they could be taken into account to design more effective immunization strategies for these high-risk age groups.
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“As with T cells, ageing is associated with a decline in naïve B cell production, an accumulation of memory B cells with limited specificities, and less robust plasma cell responses to antigen, with the antibodies produced being less effective (Siegrist and Aspinall 2009).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Siegrist and Aspinall 2009
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IgG placental transfer in healthy and pathological pregnancies
Palmeira, P., Quinello, C., Silveira-Lessa, A. L., Zago, C. A., & Carneiro-Sampaio, M. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/985646 · Cited by 1,037
Factors That Influence the Immune Response to Vaccination
Zimmermann, P., & Curtis, N. C. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00084-18 · Cited by 970
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Metadata
- Authors
- Siegrist, C.-A., & Aspinall, R.
- Affiliations
- University of Geneva (CH)
- Cranfield University (GB)
- Corresponding author
- Siegrist, Claire-Anne
- Venue
- Nature Reviews Immunology
- Published
- 2009-03
- Volume
- 9
- Issue
- 3
- Pages
- 185-194
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2019896390
- Cited by
- 659
- References
- 114
- Citations by year
- 2026: 31 · 2025: 29 · 2024: 37 · 2023: 34 · 2022: 46 · 2021: 59 · 2020: 50 · 2019: 31 · 2018: 32 · 2017: 45 · 2016: 35 · 2015: 33 · 2014: 35 · 2013: 39 · 2012: 32
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- B cell response, vaccination, infants, older adults, immunosenescence, immunodeficiency, antibody response, lymphoid microenvironment, bone marrow, vaccination strategies
- MeSH terms
- Aged, Aged, 80 and over, Aging, Animals, B-Lymphocytes, Communicable Diseases, Humans, Immunologic Memory, Infant, Infant, Newborn, Vaccination, Vaccines, Mice
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