Cited by 662T-cell and B-cell ImmunologyImmune responses and vaccinationsImmunotherapy and Immune Responses

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B-cell responses to vaccination at the extremes of age

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Siegrist, Claire-Anne, Aspinall, Richard·2009·Nature Reviews Immunology

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Abstract

Infants and the elderly share a high vulnerability to infections and therefore have specific immunization requirements. Inducing potent and sustained B-cell responses is as challenging in infants as it is in older subjects. Several mechanisms to explain the decreased B-cell responses at the extremes of age apply to both infants and the elderly. These include intrinsic B-cell limitations as well as numerous microenvironmental factors in lymphoid organs and the bone marrow. This Review describes the mechanisms that shape B-cell responses at the extremes of age and how they could be taken into account to design more effective immunization strategies for these high-risk age groups.

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Background
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Self-citation
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Self-citation
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Aging affects B‐cell antigen receptor repertoire diversity in primary and secondary lymphoid tissues
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Authors: Siegrist, C.-A., & Aspinall, R.
Affiliations: University of Geneva (CH)
Cranfield University (GB)
Corresponding author: Siegrist, Claire-Anne
ORCID: Siegrist, Claire-Anne
Aspinall, Richard
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2009-03
Volume: 9
Issue: 3
Pages: 185-194
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2508
OpenAlex: W2019896390
Cited by: 659
References: 114
Citations by year: 2026: 31 · 2025: 29 · 2024: 37 · 2023: 34 · 2022: 46 · 2021: 59 · 2020: 50 · 2019: 31 · 2018: 32 · 2017: 45 · 2016: 35 · 2015: 33 · 2014: 35 · 2013: 39 · 2012: 32
FWCI: 3.18
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Archive ouverte UNIGE (University of Geneva) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: B cell response, vaccination, infants, older adults, immunosenescence, immunodeficiency, antibody response, lymphoid microenvironment, bone marrow, vaccination strategies
MeSH terms: Aged, Aged, 80 and over, Aging, Animals, B-Lymphocytes, Communicable Diseases, Humans, Immunologic Memory, Infant, Infant, Newborn, Vaccination, Vaccines, Mice

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B-cell responses to vaccination at the extremes of age

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