The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Towards an understanding of the adjuvant action of aluminium
Open accessAbstract
The efficacy of vaccines depends on the presence of an adjuvant in conjunction with the antigen. Of these adjuvants, the ones that contain aluminium, which were first discovered empirically in 1926, are currently the most widely used. However, a detailed understanding of their mechanism of action has only started to be revealed. In this Timeline article, we briefly describe the initial discovery of aluminium adjuvants and discuss historically important advances. We also summarize recent progress in the field and discuss their implications and the remaining questions on how these adjuvants work.
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“The mechanism of action of aluminium salts (alum), although extensively used as an adjuvant for more than 80 years, remains incompletely understood15”
From A guide to vaccinology: from basic principles to new developments (2021) · cites this paper as [15]
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Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
Dinarello, C. A. (2011) · Blood · doi:10.1182/blood-2010-07-273417 · Cited by 2,248
Vaccine Adjuvants: Putting Innate Immunity to Work
Coffman, R. L., Sher, A., & Seder, R. A. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.002 · Cited by 1,927
A guide to vaccinology: from basic principles to new developments
Pollard, A. J., & Bijker, E. M. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00479-7 · Cited by 1,593
Key roles of adjuvants in modern vaccines
Reed, S. G., Orr, M. T., & Fox, C. B. (2013) · Nature Medicine · doi:10.1038/nm.3409 · Cited by 1,478
Emerging concepts in the science of vaccine adjuvants
Pulendran, B., Arunachalam, P. S., & O’Hagan, D. T. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00163-y · Cited by 1,446
Metadata
- Authors
- Marrack, P., McKee, A. S., & Munks, M. W.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Marrack, Philippa
- Venue
- Nature Reviews Immunology
- Published
- 2009-04
- Volume
- 9
- Issue
- 4
- Pages
- 287-293
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC3147301
- OpenAlex
- W1990954596
- Cited by
- 887
- References
- 63
- Citations by year
- 2026: 44 · 2025: 47 · 2024: 57 · 2023: 47 · 2022: 41 · 2021: 67 · 2020: 50 · 2019: 45 · 2018: 49 · 2017: 65 · 2016: 56 · 2015: 72 · 2014: 44 · 2013: 64 · 2012: 49
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Allergy and Infectious Diseases (P01AI022295, R37AI018785)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- alum adjuvant, aluminum salts, vaccine adjuvants, adjuvant mechanisms, vaccine efficacy, immunogenicity
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Adjuvants, Immunologic, Adsorption, Aluminum, Animals, Antibody Formation, Antigen-Presenting Cells, Antigens, Carrier Proteins, Cytoskeletal Proteins, Humans, Immunity, Cellular, Immunity, Innate, Aluminum Compounds, Models, Immunological, Caspase 1, Apoptosis Regulatory Proteins, Mice, CARD Signaling Adaptor Proteins
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