The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Autoimmune T cell responses in the central nervous system
Open accessAbstract
Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by two distinct lineages of CD4+ T cells that are defined by the production of either interferon-γ or interleukin-17. The activity of these CD4+ T cell subsets within the CNS influences the pathology and clinical course of disease. New animal models show that myelin-specific CD8+ T cells can also mediate CNS autoimmunity. This Review focuses on recent progress in delineating the pathogenic mechanisms, regulation and interplay between these different T cell subsets in CNS autoimmunity.
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
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B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
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IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
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Metadata
- Authors
- Goverman, J.
- Venue
- Nature Reviews Immunology
- Published
- 2009-06
- Volume
- 9
- Issue
- 6
- Pages
- 393-407
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2096618637
- Cited by
- 1,030
- References
- 20
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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