Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969 · see citing works

A haplotype map of the human genome

The International HapMap Consortium (2005) · Nature · doi:10.1038/nature04226 · Cited by 5,858 · see citing works

The Future of Genetic Studies of Complex Human Diseases

Risch, N., & Merikangas, K. (1996) · Science · doi:10.1126/science.273.5281.1516 · Cited by 5,355 · see citing works

Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”

Polman, C. H., Reingold, S. C., Edan, G., Filippi, M., Hartung, H., Kappos, L., Lublin, F. D., Metz, L. M., McFarland, H. F., O'Connor, P. W., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20703 · Cited by 5,017 · see citing works

Axonal transection in the lesions of multiple sclerosis

Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029 · see citing works

A Genome-Wide Association Study Identifies <i>IL23R</i> as an Inflammatory Bowel Disease Gene

Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039 · see citing works

A genome-wide association study identifies novel risk loci for type 2 diabetes

Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., et al. (2007) · Nature · doi:10.1038/nature05616 · Cited by 2,993 · see citing works

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843 · see citing works

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

Scott, L. J., Mohlke, K. L., Bonnycastle, L. L., Willer, C. J., Li, Y., Duren, W. L., Erdos, M. R., Stringham, H. M., Chines, P. S., Jackson, A. U., et al. (2007) · Science · doi:10.1126/science.1142382 · Cited by 2,753 · see citing works

Revised diagnostic criteria for neuromyelitis optica

Wingerchuk, D. M., Lennon, V. A., Pittock, S. J., Lucchinetti, C. F., & Weinshenker, B. G. (2006) · Neurology · doi:10.1212/01.wnl.0000216139.44259.74 · Cited by 2,568 · see citing works

Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

Zeggini, E., Weedon, M. N., Lindgren, C. M., Frayling, T. M., Elliott, K. S., Lango, H., Timpson, N. J., Perry, J. R. B., Rayner, N. W., Freathy, R. M., et al. (2007) · Science · doi:10.1126/science.1142364 · Cited by 2,194 · see citing works

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

Hampe, J., Franke, A., Rosenstiel, P. C., Till, A., Teuber, M., Huse, K., Albrecht, M., Gabriele Mayr, B., Vega, F. M. D. L., Briggs, J. C., et al. (2006) · Nature Genetics · doi:10.1038/ng1954 · Cited by 1,899 · see citing works

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

Viglietta, V., Baecher‐Allan, C., Weiner, H. L., & Hafler, D. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031579 · Cited by 1,858 · see citing works

CD4+CD25high Regulatory Cells in Human Peripheral Blood

Baecher‐Allan, C., Brown, J. A., Freeman, G. J., & Hafler, D. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1245 · Cited by 1,857 · see citing works

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M. M., Datta, L. W., et al. (2007) · Nature Genetics · doi:10.1038/ng2032 · Cited by 1,769 · see citing works

A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis

Begovich, A. B., Carlton, V. E. H., Honigberg, L. A., Schrodi, S. J., Chokkalingam, A. P., Alexander, H. C., Ardlie, K., Huang, Q., Smith, A. M., Spoerke, J. M., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/422827 · Cited by 1,501 · see citing works

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

Finland, G. O. T. 1. D. I., Todd, J. A., the Wellcome Trust Case Control Consortium, Walker, N. M., Cooper, J. D., Smyth, D. J., Downes, K., Plagnol, V., Bailey, R., Nejentsev, S., et al. (2007) · Nature Genetics · doi:10.1038/ng2068 · Cited by 1,456 · see citing works

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

Bottini, N., Musumeci, L., Alonso, A., Rahmouni, S., Nika, K., Rostamkhani, M., MacMurray, J. P., Meloni, T., Lucarelli, P., Pellecchia, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1323 · Cited by 1,419 · see citing works

Diagnostic criteria for multiple sclerosis

Poser, C. M., & Brinar, V. V. (2001) · Clinical Neurology and Neurosurgery · doi:10.1016/s0303-8467(00)00125-6 · Cited by 1,282 · see citing works

Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

Ehrenstein, M. R., Evans, J. G., Singh, A., Moore, S., Warnes, G., Isenberg, D. A., & Mauri, C. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040165 · Cited by 1,253 · see citing works

Genome-wide association studies: theoretical and practical concerns

Wang, W. Y. S., Barratt, B. J., Clayton, D. G., & Todd, J. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1522 · Cited by 1,159 · see citing works

Pedigree disequilibrium tests for multilocus haplotypes.

Dudbridge, F. (2003) · Genetic Epidemiology · doi:10.1002/gepi.10252 · Cited by 1,135 · see citing works

Environmental risk factors for multiple sclerosis. Part I: The role of infection

Ascherio, A., & Munger, K. L. (2007) · Annals of Neurology · doi:10.1002/ana.21117 · Cited by 1,036 · see citing works

Identification of autoantibodies associated with myelin damage in multiple sclerosis

Genain, C. P., Cannella, B., Hauser, S. L., & Raine, C. S. (1999) · Nature Medicine · doi:10.1038/5532 · Cited by 891 · see citing works

Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes

Sm, L., Dayan, C. M., Bishop, A. J., Roep, B. O., Peakman, M., & Tree, T. I. M. (2005) · Diabetes · doi:10.2337/diabetes.54.1.92 · Cited by 861 · see citing works

McAlpine's Multiple Sclerosis

(2006) · Elsevier eBooks · doi:10.1016/b978-0-443-07271-0.x5001-0 · Cited by 769 · see citing works

A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC

de Bakker, P. I. W., McVean, G., Sabeti, P. C., Miretti, M. M., Green, T., Marchini, J., Ke, X., Monsuur, A. J., Whittaker, P., Delgado, M., et al. (2006) · Nature Genetics · doi:10.1038/ng1885 · Cited by 766 · see citing works

Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis

Lucchinetti, C. F., Brück, W., Rodriguez, M., & Lassmann, H. (1996) · Brain Pathology · doi:10.1111/j.1750-3639.1996.tb00854.x · Cited by 733 · see citing works

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

Smyth, D. J., Cooper, J. D., Bailey, R., Field, S., Burren, O. S., Smink, L. J., Guja, C., Ionescu-Tirgoviste, C., Widmer, B., Dunger, D. B., et al. (2006) · Nature Genetics · doi:10.1038/ng1800 · Cited by 688 · see citing works

A full genome search in multiple sclerosis

Ebers, G. C., Kukay, K., Bulman, D. E., Sadovnick, A. D., Rice, G. P., Anderson, C. M., Armstrong, H., Cousin, K., Bell, R. B., Hader, W. J., et al. (1996) · Nature Genetics · doi:10.1038/ng0896-472 · Cited by 662 · see citing works

Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis

for the Multiple Sclerosis Genetics Group, Gregory, S. G., Schmidt, S., Seth, P., Oksenberg, J. R., Hart, J., Prokop, A., Caillier, S. J., Ban, M., Goris, A., et al. (2007) · Nature Genetics · doi:10.1038/ng2103 · Cited by 657 · see citing works

A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex

Haines, J. L., Ter‐Minassian, M., Bazyk, A., Gusella, J. F., Kim, D. J., Terwedow, H. A., Pericak‐Vance, M. A., Rimmler, J. B., Haynes, C. S., Roses, A. D., et al. (1996) · Nature Genetics · doi:10.1038/ng0896-469 · Cited by 650 · see citing works

A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22

Sawcer, S. J., Jones, H. B., Feakes, R. W., Gray, J., Smaldon, N., Chataway, J., Robertson, N. P., Clayton, D. G., Goodfellow, P. N., & Compston, A. (1996) · Nature Genetics · doi:10.1038/ng0896-464 · Cited by 643 · see citing works

Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus

Smyth, D. J., Cooper, J. D., Collins, J. E., Heward, J. M., Franklyn, J. A., Howson, J. M. M., Vella, A. V., Nutland, S. L., Rance, H. E., Maier, L. M., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.11.3020 · Cited by 504 · see citing works

The Codon 620 Tryptophan Allele of the Lymphoid Tyrosine Phosphatase (LYP) Gene Is a Major Determinant of Graves’ Disease

Velaga, M., Wilson, V., Jennings, C., Owen, C. J., Herington, S. D., Donaldson, P. T., Ball, S. G., James, R. A., Quinton, R., Perros, P., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1108 · Cited by 464 · see citing works

Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

Seddon, B. P., Tomlinson, P. D., & Zamoyska, R. (2003) · Nature Immunology · doi:10.1038/ni946 · Cited by 457 · see citing works

Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis

Haas, J., Hug, A., Viehöver, A., Fritzsching, B., Falk, C. S., Filser, A., Vetter, T., Milkova, L., Korporal, M., Fritz, B., et al. (2005) · European Journal of Immunology · doi:10.1002/eji.200526065 · Cited by 450 · see citing works

Three functional variants of IFN regulatory factor 5 ( <i>IRF5</i> ) define risk and protective haplotypes for human lupus

Graham, R. R., Kyogoku, C., Sigurdsson, S., Vlasova, I. A., Davies, L. R. L., Baechler, E. C., Plenge, R. M., Koeuth, T., Ortmann, W. A., Hom, G., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701266104 · Cited by 450 · see citing works

Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosis.

Jw, P., & Rg, W. (1978) · PubMed · Cited by 417 · see citing works

CD4+CD25bright Regulatory T Cells Actively Regulate Inflammation in the Joints of Patients with the Remitting Form of Juvenile Idiopathic Arthritis

de Kleer, I. M., Wedderburn, L. R., Taams, L. S., Patel, A., Varsani, H., Klein, M. A., de Jager, W., Pugayung, G., Giannoni, F., Rijkers, G. T., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.10.6435 · Cited by 399 · see citing works

Localization of a Type 1 Diabetes Locus in the IL2RA/CD25 Region by Use of Tag Single-Nucleotide Polymorphisms

Vella, A. V., Cooper, J. D., Lowe, C. E., Walker, N. M., Nutland, S. L., Widmer, B., Jones, R. W., Ring, S. M., McArdle, W. L., Pembrey, M. E., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/429843 · Cited by 352 · see citing works

Multiple sclerosis

Hafler, D. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21357 · Cited by 336 · see citing works

Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon β

Bielekova, B., Richert, N. D., Howard, T., Blevins, G., Markovic‐Plese, S., McCartin, J., Wuerfel, J. T., Ohayon, J. M., Waldmann, T. A., McFarland, H. F., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402653101 · Cited by 314 · see citing works

A High-Density Screen for Linkage in Multiple Sclerosis

(2005) · The American Journal of Human Genetics · doi:10.1086/444547 · Cited by 297 · see citing works

Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions.

Wucherpfennig, K. W., Newcombe, J., Li, H., Keddy, C., Cuzner, M. L., & Hafler, D. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4588 · Cited by 278 · see citing works

Evaluating and improving power in whole-genome association studies using fixed marker sets

Pe’er, I., de Bakker, P. I. W., Maller, J., Yelensky, R., Altshuler, D., & Daly, M. J. (2006) · Nature Genetics · doi:10.1038/ng1816 · Cited by 275 · see citing works

A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

Reich, D., Patterson, N. J., Jager, P. L. D., McDonald, G. J., Waliszewska, A., Tandon, A., Lincoln, R., DeLoa, C., Fruhan, S. A., Cabre, P., et al. (2005) · Nature Genetics · doi:10.1038/ng1646 · Cited by 269 · see citing works

Human regulatory T cells and their role in autoimmune disease

Baecher‐Allan, C., & Hafler, D. A. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00417.x · Cited by 262 · see citing works

Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.

He, Y. W., & Malek, T. R. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.1.289 · Cited by 211 · see citing works

A second major histocompatibility complex susceptibility locus for multiple sclerosis

Yeo, T. W., Jager, P. L. D., Gregory, S. G., Barcellos, L. F., Walton, A., Goris, A., Fenoglio, C., Ban, M., Taylor, C. J., Goodman, R. S., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21063 · Cited by 175 · see citing works

Antibodies from Inflamed Central Nervous System Tissue Recognize Myelin Oligodendrocyte Glycoprotein

O’Connor, K. C., Appel, H., Bregoli, L., Call, M. E., Catz, I., Chan, J. A.-W., Moore, N., Warren, K. G., Wong, S. J., Hafler, D. A., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.3.1974 · Cited by 168 · see citing works

Treatment of multiple sclerosis with an anti–interleukin‐2 receptor monoclonal antibody

ROSE, J. W., Watt, H. E., White, A. T., & Carlson, N. G. (2004) · Annals of Neurology · doi:10.1002/ana.20287 · Cited by 163 · see citing works

Association of the interleukin‐2 receptor alpha (IL‐2Rα)/CD25 gene region with Graves’ disease using a multilocus test and tag SNPs

Brand, O. J., Lowe, C. E., Heward, J. M., Franklyn, J. A., Cooper, J. D., Todd, J. A., & Gough, S. C. L. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02762.x · Cited by 159 · see citing works

Function of the IL-2R for Thymic and Peripheral CD4+CD25+ Foxp3+ T Regulatory Cells

Bayer, A. L., Yu, A., & Malek, T. R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4062 · Cited by 158 · see citing works

Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis

Zhang, Z., Duvefelt, K., Svensson, F., Masterman, T., Jonasdottir, G., Salter, H., Emahazion, T., Hellgren, D., Falk, G., Olsson, T. P., et al. (2005) · Genes and Immunity · doi:10.1038/sj.gene.6364171 · Cited by 136 · see citing works

The R620W Polymorphism of the Protein Tyrosine Phosphatase PTPN22 Is Not Associated with Multiple Sclerosis

Begovich, A. B., Caillier, S. J., Alexander, H. C., Penko, J. M., Hauser, S. L., Barcellos, L. F., & Oksenberg, J. R. (2004) · The American Journal of Human Genetics · doi:10.1086/427244 · Cited by 114 · see citing works

Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-α gene and their associations with multiple sclerosis

Teutsch, S. M., Booth, D. R., Bennetts, B., Heard, R. N., & Stewart, G. J. (2003) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200994 · Cited by 99 · see citing works

Gaining insight into PTPN22 and autoimmunity

Gregersen, P. K. (2005) · Nature Genetics · doi:10.1038/ng1205-1300 · Cited by 99 · see citing works

Preferential expansion of autoreactive T lymphocytes from the memory T-cell pool by IL-7

Bielekova, B., Muraro, P. A., Golestaneh, L., Pascal, J., McFarland, H. F., & Martinꝉ, R. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00200-3 · Cited by 73 · see citing works

Selective Availability of IL-2 Is a Major Determinant Controlling the Production of CD4+CD25+Foxp3+ T Regulatory Cells

Yu, A., & Malek, T. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5115 · Cited by 57 · see citing works

IL2RA/CD25 polymorphisms contribute to multiple sclerosis susceptibility

Matesanz, F., Caro‐Maldonado, A., Fedetz, M., Fernández, Ó., Milne, R. L., Guerrero, M., Delgado, C., & Alcina, A. (2007) · Journal of Neurology · doi:10.1007/s00415-006-0416-4 · Cited by 50 · see citing works

Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis

Jager, P. L. D., Sawcer, S. J., Waliszewska, A., Farwell, L. M., Wild, G., Cohen, A., Langelier, D., Bitton, A., Compston, A., Hafler, D. A., et al. (2005) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201548 · Cited by 38 · see citing works

Association of Fcγ receptor IIA, but not IIB and IIIA, polymorphisms with systemic lupus erythematosus: A family‐based association study in Caucasians

Kyogoku, C., Tsuchiya, N., Wu, H. L., Tsao, B. P., & Tokunaga, K. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20029 · Cited by 36 · see citing works

Current understanding of the genetic aetiology of rheumatoid arthritis and likely future developments

Criswell, L. A., & Gregersen, P. K. (2005) · Lara D. Veeken · doi:10.1093/rheumatology/kei054 · Cited by 16 · see citing works

Multiple sclerosis.

Compston, A., & Coles, A. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61620-7 · Cited by 1,184 · see citing works

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

The International Multiple Sclerosis Genetics Consortium & The Wellcome Trust Case Control Consortium 2 (2011) · Nature · doi:10.1038/nature10251 · Cited by 2,697 · see citing works

Multiple sclerosis

Thompson, A. J., Baranzini, S. E., Geurts, J. J. G., Hemmer, B., & Ciccarelli, O. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30481-1 · Cited by 1,856 · see citing works

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

Trapp, B. D., & Nave, K.-A. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094313 · Cited by 1,724 · see citing works

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

International Multiple Sclerosis Genetics Consortium, Patsopoulos, N. A., Baranzini, S. E., Santaniello, A., Shoostari, P., Cotsapas, C., Wong, G., Beecham, A. H., James, T., Replogle, J., et al. (2019) · Science · doi:10.1126/science.aav7188 · Cited by 1,471 · see citing works

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

International Multiple Sclerosis Genetics Consortium (IMSGC) (2013) · Nature Genetics · doi:10.1038/ng.2770 · Cited by 1,386 · see citing works

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene–disease associations

Denny, J. C., Ritchie, M. D., Basford, M. A., Pulley, J. M., Bastarache, L., Brown-Gentry, K., Wang, D., Masys, D. R., Roden, D. M., & Crawford, D. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq126 · Cited by 1,219 · see citing works

Human genetic variation and its contribution to complex traits

Frazer, K. A., Murray, S. S., Schork, N. J., & Topol, E. J. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2554 · Cited by 1,073 · see citing works

Autoimmune T cell responses in the central nervous system

Goverman, J. M. (2009) · Nature reviews. Immunology · doi:10.1038/nri2550 · Cited by 1,025 · see citing works

SNP Genotyping Using the Sequenom MassARRAY iPLEX Platform

Gabriel, S., Ziaugra, L., & Tabbaa, D. (2009) · Current Protocols in Human Genetics · doi:10.1002/0471142905.hg0212s60 · Cited by 960 · see citing works

How to Interpret a Genome-wide Association Study

Pearson, T. A. (2008) · JAMA · doi:10.1001/jama.299.11.1335 · Cited by 964 · see citing works

The genetics and immunopathogenesis of inflammatory bowel disease

Cho, J. H. (2008) · Nature Reviews Immunology · doi:10.1038/nri2340 · Cited by 940 · see citing works

A copy number variation map of the human genome

Zarrei, M., MacDonald, J. R., Merico, D., & Scherer, S. W. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3871 · Cited by 921 · see citing works

A HapMap harvest of insights into the genetics of common disease

Manolio, T. A., Brooks, L. D., & Collins, F. S. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34772 · Cited by 889 · see citing works

Multiple Sclerosis: Mechanisms and Immunotherapy

Baecher-Allan, C., Kaskow, B. J., & Weiner, H. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.021 · Cited by 938 · see citing works

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

International MS Genetics Consortium, De Jager, P. L., Jia, X., Wang, J., de Bakker, P. I. W., Ottoboni, L., Aggarwal, N. T., Piccio, L., Raychaudhuri, S., Tran, D., et al. (2009) · Nature Genetics · doi:10.1038/ng.401 · Cited by 800 · see citing works

Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain

Serafini, B., Rosicarelli, B., Franciotta, D. M., Magliozzi, R., Reynolds, R., Cinque, P. M., Andreoni, L., Trivedi, P., Salvetti, M., Faggioni, A., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071030 · Cited by 765 · see citing works

An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people

Nelson, M. R., Wegmann, D., Ehm, M. G., Kessner, D., St. Jean, P., Verzilli, C., Shen, J., Tang, Z., Bacanu, S.-A., Fraser, D., et al. (2012) · Science · doi:10.1126/science.1217876 · Cited by 647 · see citing works

Revisiting IL-2: Biology and therapeutic prospects

Abbas, A. K., Trotta, E., Simeonov, D. R., Marson, A., & Bluestone, J. A. (2018) · Science Immunology · doi:10.1126/sciimmunol.aat1482 · Cited by 631 · see citing works

New IBD genetics: common pathways with other diseases

Lees, C. W., Barrett, J. C., Parkes, M., & Satsangi, J. (2011) · Gut · doi:10.1136/gut.2009.199679 · Cited by 635 · see citing works

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

Kiryluk, K., Li, Y., Scolari, F., Sanna‐Cherchi, S., Choi, M., Verbitsky, M., Fasel, D. A., Lata, S., Prakash, S., Shapiro, S. L., et al. (2014) · Nature Genetics · doi:10.1038/ng.3118 · Cited by 630 · see citing works

Environmental factors and multiple sclerosis

Ebers, G. C. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70042-5 · Cited by 629 · see citing works

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis

Friese, M. A., Schattling, B., & Fugger, L. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.37 · Cited by 628 · see citing works

Vitamin D and multiple sclerosis

Ascherio, A., Munger, K. L., & Simon, K. C. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70086-7 · Cited by 591 · see citing works

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

Yang, X.-P., Ghoreschi, K., Steward-Tharp, S. M., Rodriguez-Canales, J., Zhu, J., Grainger, J. R., Hirahara, K., Sun, H.-W., Wei, L., Vahedi, G., et al. (2011) · Nature Immunology · doi:10.1038/ni.1995 · Cited by 583 · see citing works

Deconstructing the Peptide-MHC Specificity of T Cell Recognition

Birnbaum, M. E., Mendoza, J. L., Sethi, D. K., Dong, S., Glanville, J., Dobbins, J., Özkan, E., Davis, M. M., Wucherpfennig, K. W., & García, K. C. (2014) · Cell · doi:10.1016/j.cell.2014.03.047 · Cited by 558 · see citing works

Detecting shared pathogenesis from the shared genetics of immune-related diseases

Zhernakova, A., van Diemen, C. C., & Wijmenga, C. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2489 · Cited by 551 · see citing works

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

The Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene) (2009) · Nature Genetics · doi:10.1038/ng.396 · Cited by 550 · see citing works

Multiple sclerosis: risk factors, prodromes, and potential causal pathways

Ramagopalan, S. V., Dobson, R., Meier, U. C., & Giovannoni, G. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70094-6 · Cited by 548 · see citing works

Glial influence on the blood brain barrier

Alvarez, J. I., Katayama, T., & Prat, A. (2013) · Glia · doi:10.1002/glia.22575 · Cited by 542 · see citing works

Sex and gender issues in multiple sclerosis

Harbo, H. F., Gold, R., & Tintoré, M. (2013) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285613488434 · Cited by 529 · see citing works

Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D

Ramagopalan, S. V., Maugeri, N., Handunnetthi, L., Lincoln, M. R., Orton, S. M., Dyment, D. A., DeLuca, G. C., Herrera, B. M., Chao, M. J., Sadovnick, A. D., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000369 · Cited by 523 · see citing works

The epidemiology of multiple sclerosis

Goodin, D. S. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-12-802973-2.00011-2 · Cited by 517 · see citing works

Genetics of type 1A diabetes

Concannon, P., Rich, S. S., & Nepom, G. T. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0808284 · Cited by 510 · see citing works

Multiple sclerosis

Nylander, A., & Hafler, D. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58649 · Cited by 495 · see citing works

Antiviral immune responses: triggers of or triggered by autoimmunity?

Münz, C., Lünemann, J. D., Getts, M. T., & Miller, S. D. (2009) · Nature reviews. Immunology · doi:10.1038/nri2527 · Cited by 480 · see citing works

Epidemiology of multiple sclerosis

Leray, E., Moreau, T., Fromont, A., & Edan, G. (2016) · Revue Neurologique · doi:10.1016/j.neurol.2015.10.006 · Cited by 478 · see citing works

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

Baranzini, S. E., Wang, J., Gibson, R. A., Galwey, N., Naegelin, Y., Barkhof, F., Radue, E.-W., Lindberg, R. L. P., Uitdehaag, B. M. G., Johnson, M. R., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddn388 · Cited by 476 · see citing works

Epstein–Barr virus and multiple sclerosis

Soldan, S. S., & Lieberman, P. M. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00770-5 · Cited by 482 · see citing works

Identification of Therapeutic Targets for Quiescent, Chemotherapy-Resistant Human Leukemia Stem Cells

Saito, Y., Kitamura, H., Hijikata, A., Tomizawa-Murasawa, M., Tanaka, S., Takagi, S., Uchida, N., Suzuki, N., Sone, A., Najima, Y., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000349 · Cited by 458 · see citing works

Long non-coding RNAs in nervous system function and disease

Qureshi, I., Mattick, J. S., & Mehler, M. F. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.110 · Cited by 426 · see citing works

Recent Insights Into the Genetics of Inflammatory Bowel Disease

Cho, J. H., & Brant, S. R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.046 · Cited by 425 · see citing works

Class II HLA interactions modulate genetic risk for multiple sclerosis

the International Multiple Sclerosis Genetics Consortium (2015) · Nature Genetics · doi:10.1038/ng.3395 · Cited by 418 · see citing works

Variant of TYR and Autoimmunity Susceptibility Loci in Generalized Vitiligo

Jin, Y., Birlea, S. A., Fain, P. R., Gowan, K., Riccardi, S. L., Holland, P. J., Mailloux, C. M., Sufit, A., Hutton, S. M., Amadi‐Myers, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0908547 · Cited by 415 · see citing works

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia

Zenatti, P. P., Ribeiro, D., Li, W., Zuurbier, L. C., da Silva, M. C., Paganin, M., Tritapoe, J. M., Hixon, J. A., Silveira, A. B., Cardoso, B. A., et al. (2011) · Nature Genetics · doi:10.1038/ng.924 · Cited by 414 · see citing works

Multiple sclerosis genetics

Sawcer, S. J., Franklin, R. J. M., & Ban, M. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70041-9 · Cited by 404 · see citing works

Pathway and network-based analysis of genome-wide association studies in multiple sclerosis

Baranzini, S. E., Galwey, N. W., Wang, J., Khankhanian, P., Lindberg, R., Pelletier, D., Wu, W., Uitdehaag, B. M. J., Kappos, L., GeneMSA Consortium, et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp120 · Cited by 383 · see citing works

Frontotemporal dementia and its subtypes: a genome-wide association study

Ferrari, R., Hernandez, D. G., Nalls, M. A., Rohrer, J. D., Ramasamy, A., Kwok, J. B. J., Dobson-Stone, C., Brooks, W. S., Schofield, P. R., Halliday, G. M., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70065-1 · Cited by 383 · see citing works

Rheumatoid arthritis association at 6q23

Thomson, W., Barton, A. C., Ke, X., Eyre, S., Hinks, A., Bowes, J., Donn, R. P., Symmons, D. P. M., Hider, S., Bruce, I. N., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.32 · Cited by 381 · see citing works

Cytokine and cytokine receptor gene polymorphisms and their functionality

Smith, A. J. P., & Humphries, S. E. (2009) · Cytokine &amp; Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.11.006 · Cited by 374 · see citing works

Analysis of CD161 expression on human CD8 + T cells defines a distinct functional subset with tissue-homing properties

Billerbeck, E., Kang, Y.-H., Walker, L. J., Lockstone, H. E., Grafmüller, S., Fleming, V. M., Jonathan Flint, C., Willberg, C. B., Bengsch, B., Seigel, B., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914839107 · Cited by 370 · see citing works

Genomics and the Multifactorial Nature of Human Autoimmune Disease

Cho, J. H., & Gregersen, P. K. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1100030 · Cited by 349 · see citing works

Genome‐wide meta‐analysis identifies novel multiple sclerosis susceptibility loci

Patsopoulos, N. A., the Bayer Pharma MS Genetics Working Group, T. S. C. O. S. E. I. A. A. C., & de Bakker, P. I. W. (2011) · Annals of Neurology · doi:10.1002/ana.22609 · Cited by 353 · see citing works

The genetics of multiple sclerosis: SNPs to pathways to pathogenesis

Oksenberg, J. R., Baranzini, S. E., Sawcer, S., & Hauser, S. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2395 · Cited by 347 · see citing works

An update on immunopathogenesis, diagnosis, and treatment of multiple sclerosis

Garg, N., & Smith, T. W. (2015) · Brain and Behavior · doi:10.1002/brb3.362 · Cited by 351 · see citing works

The challenge of multiple sclerosis: How do we cure a chronic heterogeneous disease?

Weiner, H. L. (2009) · Annals of Neurology · doi:10.1002/ana.21640 · Cited by 342 · see citing works

Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis

Srivastava, R., Aslam, M., Kalluri, S. R., Schirmer, L., Buck, D., Tackenberg, B., Rothhammer, V., Chan, A., Gold, R., Berthele, A., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1110740 · Cited by 344 · see citing works

Recent Advances in the Genetics of Autoimmune Disease

Gregersen, P. K., & Olsson, L. M. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132653 · Cited by 337 · see citing works

Multiple sclerosis—a quiet revolution

Ransohoff, R. M., Hafler, D. A., & Lucchinetti, C. F. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.14 · Cited by 339 · see citing works

Robust Replication of Genotype-Phenotype Associations across Multiple Diseases in an Electronic Medical Record

Ritchie, M. D., Denny, J. C., Crawford, D. C., Ramirez, A. H., Weiner, J., Pulley, J. M., Basford, M., Brown-Gentry, K. D., Balser, J. R., Masys, D. R., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.03.003 · Cited by 320 · see citing works

Myelin Regeneration: A Recapitulation of Development?

Fancy, S. P. J., Chan, J. R., Baranzini, S. E., Franklin, R. J. M., & Rowitch, D. H. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113629 · Cited by 321 · see citing works

Autoimmune diseases: insights from genome-wide association studies

Lettre, G., & Rioux, J. D. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn246 · Cited by 317 · see citing works

Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects

Patsopoulos, N. A., Barcellos, L. F., Hintzen, R. Q., Schaefer, C., van Duijn, C. M., Noble, J. A., Raj, T., IMSGC, ANZgene, Gourraud, P.-A., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003926 · Cited by 312 · see citing works

Daclizumab in active relapsing multiple sclerosis (CHOICE study): a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta

Wynn, D. R., Kaufman, M., Montalbán, X., Vollmer, T. R., Simon, J. H., Elkins, J. S., O’Neill, G. N., Neyer, L., Sheridan, J. P., Wang, C., et al. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70033-8 · Cited by 300 · see citing works

Incidence of multiple sclerosis in multiple racial and ethnic groups

Langer-Gould, A. M., Brara, S. M., Beaber, B., & Zhang, J. L. (2013) · Neurology · doi:10.1212/wnl.0b013e3182918cc2 · Cited by 299 · see citing works

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

Cao, Y., Goods, B. A., Raddassi, K., Nepom, G. T., Kwok, W. W., Love, J. C., & Hafler, D. A. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa8038 · Cited by 290 · see citing works

CD4+FOXP3+ T Regulatory Cells in Human Autoimmunity: More Than a Numbers Game

Long, S. A., & Buckner, J. H. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003224 · Cited by 294 · see citing works

Epigenetic principles and mechanisms underlying nervous system functions in health and disease

Mehler, M. F. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.10.001 · Cited by 292 · see citing works

The genetics of multiple sclerosis: an up‐to‐date review

Gourraud, P., Harbo, H. F., Hauser, S. L., & Baranzini, S. E. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01134.x · Cited by 278 · see citing works

Epigenome-wide differences in pathology-free regions of multiple sclerosis–affected brains

Huynh, J. L., Garg, P., Thin, T. H., Yoo, S., Dutta, R., Trapp, B. D., Haroutunian, V. H., Zhu, J., Donovan, M. J., Sharp, A. J., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3588 · Cited by 273 · see citing works

Unravelling the human genome–phenome relationship using phenome-wide association studies

Bush, W. S., Oetjens, M. T., & Crawford, D. C. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2015.36 · Cited by 267 · see citing works

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

Dendrou, C. A., Plagnol, V., Fung, E., Yang, J. H. M., Downes, K., Cooper, J. D., Nutland, S., Coleman, G., Himsworth, M., Hardy, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.434 · Cited by 274 · see citing works

Tissue-Specific Genetic Control of Splicing: Implications for the Study of Complex Traits

Heinzen, E. L., Ge, D., Cronin, K. D., Maia, J. M., Shianna, K. V., Gabriel, W. N., Welsh-Bohmer, K. A., Hulette, C. M., Denny, T. N., & Goldstein, D. B. (2008) · PLoS Biology · doi:10.1371/journal.pbio.1000001 · Cited by 269 · see citing works

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

Fung, E., Smyth, D. J., Howson, J. M. M., Cooper, J. D., Walker, N. M., Stevens, H. E., Wicker, L. S., & Todd, J. A. (2008) · Genes and Immunity · doi:10.1038/gene.2008.99 · Cited by 267 · see citing works

NKT Cell-Dependent Amelioration of a Mouse Model of Multiple Sclerosis by Altering Gut Flora

Yokote, H., Miyake, S., Croxford, J. L., Oki, S., Mizusawa, H., & Yamamura, T. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080622 · Cited by 264 · see citing works

Interleukin‐2 in the development and control of inflammatory disease

Hoyer, K. K., Dooms, H., Barron, L., & Abbas, A. K. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00697.x · Cited by 262 · see citing works

Natural Naive CD4+CD25+CD127low Regulatory T Cell (Treg) Development and Function Are Disturbed in Multiple Sclerosis Patients: Recovery of Memory Treg Homeostasis during Disease Progression

Venken, K., Hellings, N., Broekmans, T., Hensen, K., Rummens, J., & Stinissen, P. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.6411 · Cited by 260 · see citing works

Genome-wide Association Study Implicates a Chromosome 12 Risk Locus for Late-Onset Alzheimer Disease

Beecham, G. W., Martin, E. R., Li, Y.-J., Slifer, M. A., Gilbert, J. R., Haines, J. L., & Pericak-Vance, M. A. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.12.008 · Cited by 260 · see citing works

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases

International MHC and Autoimmunity Genetics Network (IMAGEN)*, Rioux, J. D., Goyette, P., Vyse, T. J., Hammarström, L. L. G., Fernando, M. M. A., Green, T. J., Jager, P. L. D., Foisy, S., Wang, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909307106 · Cited by 256 · see citing works

A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis

Weiner, H. L. (2008) · Journal of Neurology · doi:10.1007/s00415-008-1002-8 · Cited by 256 · see citing works

The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease

Leung, S., Liu, X., Fang, L., Chen, X. X., Guo, T. B., & Zhang, J. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.22 · Cited by 252 · see citing works

The IL-2 – IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor

Damoiseaux, J. G. M. C. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108515 · Cited by 253 · see citing works

The Generation R Study Biobank: a resource for epidemiological studies in children and their parents

Jaddoe, V. W. V., Bakker, R., van Duijn, C. M., van der Heijden, A. J., Lindemans, J. W., Mackenbach, J. P., Moll, H. A., Steegers, E. A. P., Tiemeier, H. W., Uitterlinden, A. G., et al. (2007) · European Journal of Epidemiology · doi:10.1007/s10654-007-9209-z · Cited by 248 · see citing works

Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene

Jakkula, E., Leppä, V., Sulonen, A.-M., Varilo, T., Kallio, S., Kemppinen, A., Purcell, S., Koivisto, K., Tienari, P., Sumelahti, M.-L., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.01.017 · Cited by 245 · see citing works

IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production

Maier, L. M., Lowe, C. E., Cooper, J. D., Downes, K., Anderson, D. E., Severson, C., Clark, P., Healy, B. C., Walker, N. M., Aubin, C., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000322 · Cited by 245 · see citing works

Is multiple sclerosis a mitochondrial disease?

Mao, P., & Reddy, P. H. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.07.002 · Cited by 242 · see citing works

Neurosteroids as regulators of neuroinflammation

Yılmaz, C., Karali, K., Fodelianaki, G., Gravanis, A., Chavakis, T., Charalampopoulos, I., & Alexaki, V. I. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100788 · Cited by 245 · see citing works

MicroRNAs miR-17 and miR-20a Inhibit T Cell Activation Genes and Are Under-Expressed in MS Whole Blood

Cox, M., Cairns, M. J., Gandhi, K. S., Carroll, A. P., Moscovis, S. M., Stewart, G. J., Broadley, S., Scott, R. J., Booth, D. R., & Lechner‐Scott, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012132 · Cited by 239 · see citing works

The Genetics of Multiple Sclerosis: From 0 to 200 in 50 Years

Baranzini, S. E., & Oksenberg, J. R. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.09.004 · Cited by 238 · see citing works

Intersection of population variation and autoimmunity genetics in human T cell activation

Ye, C. J., Feng, T., Kwon, H.-K., Raj, T., Wilson, M. T., Asinovski, N., McCabe, C., Lee, M. H., Frohlich, I., Paik, H.-I., et al. (2014) · Science · doi:10.1126/science.1254665 · Cited by 236 · see citing works

CD226 Gly307Ser association with multiple autoimmune diseases

Hafler, J., Maier, L., Cooper, J. D., Plagnol, V., Hinks, A., Simmonds, M., Stevens, H. E., Walker, N., Healy, B., Howson, J., et al. (2008) · Genes and Immunity · doi:10.1038/gene.2008.82 · Cited by 248 · see citing works

Butyrate suppresses demyelination and enhances remyelination

Chen, T., Noto, D., Hoshino, Y., Mizuno, M., & Miyake, S. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1552-y · Cited by 229 · see citing works

Regulatory T cells in autoimmune neuroinflammation

Kleinewietfeld, M., & Hafler, D. A. (2014) · Immunological Reviews · doi:10.1111/imr.12169 · Cited by 230 · see citing works

Rare variants in the CYP27B1 gene are associated with multiple sclerosis

Ramagopalan, S. V., Dyment, D. A., Cader, M. Z., Morrison, K., Disanto, G., Morahan, J. M., Berlanga‐Taylor, A. J., Handel, A. E., DeLuca, G. C., Sadovnick, A. D., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22678 · Cited by 232 · see citing works

Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting

Charabati, M., Wheeler, M. A., Weiner, H. L., & Quintana, F. J. (2023) · Cell · doi:10.1016/j.cell.2023.03.008 · Cited by 229 · see citing works

The Central Nervous System

Frosch, M. P., Anthony, D. C., & Girolami, U. D. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4377-0792-2.50033-x · Cited by 228 · see citing works

An application of Random Forests to a genome-wide association dataset: Methodological considerations & new findings

Goldstein, B. A., Hubbard, A., Cutler, A., & Barcellos, L. F. (2010) · BMC Genetics · doi:10.1186/1471-2156-11-49 · Cited by 226 · see citing works

The genetics and immunobiology of IgA nephropathy

Kiryluk, K., & Novák, J. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74475 · Cited by 222 · see citing works

A Genome‐wide Association Study of Autism Reveals a Common Novel Risk Locus at 5p14.1

Ma, D., Salyakina, D., Jaworski, J. M., Konidari, I., Whitehead, P. L., Andersen, A. N., Hoffman, J. D., Slifer, S. H., Hedges, D. J., Cukier, H. N., et al. (2009) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2009.00523.x · Cited by 221 · see citing works

Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI

Farrell, R. A., Antony, D., Wall, G., Clark, D. A., Fisniku, L., Swanton, J. K., Khaleeli, Z., Schmierer, K., Miller, D. H., & Giovannoni, G. (2009) · Neurology · doi:10.1212/wnl.0b013e3181aa29fe · Cited by 219 · see citing works

News in brief

(2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70214-4

Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis

for the Multiple Sclerosis Genetics Group, Gregory, S. G., Schmidt, S., Seth, P., Oksenberg, J. R., Hart, J., Prokop, A., Caillier, S. J., Ban, M., Goris, A., et al. (2007) · Nature Genetics · doi:10.1038/ng2103 · Cited by 657 · see citing works

Risk alleles for multiple sclerosis in multiplex families

D’Netto, M. J., Ward, H., Morrison, K., Ramagopalan, S. V., Dyment, D. A., DeLuca, G. C., Handunnetthi, L., Sadovnick, A. D., & Ebers, G. C. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a92c25 · Cited by 61 · see citing works

Decoding multiple sclerosis: an update on genomics and future directions

Oksenberg, J. R. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.865867 · Cited by 66 · see citing works

Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

Zuvich, R. L., McCauley, J. L., Oksenberg, J. R., Sawcer, S. J., Jager, P. L. D., Aubin, C., Cross, A. H., Piccio, L. M., Aggarwal, N. T., Evans, D. A., et al. (2010) · Human Genetics · doi:10.1007/s00439-010-0789-4 · Cited by 62 · see citing works