The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution
Open accessAbstract
Natural killer (NK) cells have roles in immunity and reproduction that are controlled by variable receptors that recognize MHC class I molecules. The variable NK cell receptors found in humans are specific to simian primates, in which they have progressively co-evolved with MHC class I molecules. The emergence of the MHC-C gene in hominids drove the evolution of a system of NK cell receptors for MHC-C molecules that is most elaborate in chimpanzees. By contrast, the human system of MHC-C receptors seems to have been subject to different selection pressures that have acted in competition on the immunological and reproductive functions of MHC class I molecules. We suggest that this compromise facilitated the development of the bigger brains that enabled archaic and modern humans to migrate out of Africa and populate other continents.
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Cites
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Self-citation
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Metadata
- Authors
- Parham, P., & Moffett, A.
- Venue
- Nature Reviews Immunology
- Published
- 2013-01-21
- Volume
- 13
- Issue
- 2
- Pages
- 133-144
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2013435992
- Cited by
- 476
- References
- 96
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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