MHC class I molecules and kirs in human history, health and survival

Initial sequencing and comparative analysis of the mouse genome

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Of Mice and Not Men: Differences between Mouse and Human Immunology

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Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants

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Natural killer cells and pregnancy

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HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection

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Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS

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Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success

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Human Diversity in Killer Cell Inhibitory Receptor Genes

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KIR: Diverse, Rapidly Evolving Receptors of Innate and Adaptive Immunity

Vilches, C., & Parham, P. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.092501.134942 · Cited by 984 · see citing works

Interferon γ Contributes to Initiation of Uterine Vascular Modification, Decidual Integrity, and Uterine Natural Killer Cell Maturation during Normal Murine Pregnancy

Ashkar, A. A., Santo, J. P. D., & Croy, B. A. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.259 · Cited by 847 · see citing works

Functionally and Structurally Distinct NK Cell Receptor Repertoires in the Peripheral Blood of Two Human Donors

Valiante, N. M., Uhrberg, M., Shilling, H. G., Lienert-Weidenbach, K., Arnett, K. L., D’Andrea, A., Phillips, J. H., Lanier, L. L., & Parham, P. (1997) · Immunity · doi:10.1016/s1074-7613(00)80393-3 · Cited by 726 · see citing works

A Human Histocompatibility Leukocyte Antigen (HLA)-G–specific Receptor Expressed on All Natural Killer Cells

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Natural killer cells and dendritic cells: rendezvous in abused tissues

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Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey

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Plasticity in the organization and sequences of human KIR/ILT gene families

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Unravelling natural killer cell function: triggering and inhibitory human NK receptors

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Immune functions encoded by the natural killer gene complex

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Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors

Giebel, S. (2003) · Blood · doi:10.1182/blood-2003-01-0091 · Cited by 545 · see citing works

The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor.

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HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.

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Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells.

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The killer cell immunoglobulin‐like receptor (KIR) genomic region: gene‐order, haplotypes and allelic polymorphism

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Determinants of Antileukemia Effects of Allogeneic NK Cells

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Direct Binding and Functional Transfer of NK Cell Inhibitory Receptors Reveal Novel Patterns of HLA-C Allotype Recognition

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Interplay of natural killer cells and their receptors with the adaptive immune response

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Natural killer cell receptor signaling

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Killer Ig-Like Receptor Haplotype Analysis by Gene Content: Evidence for Genomic Diversity with a Minimum of Six Basic Framework Haplotypes, Each with Multiple Subsets

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Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants

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Human natural killer cell deficiencies and susceptibility to infection

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Evolution of innate and adaptive immunity: can we draw a line?

Flajnik, M. F., & DuPasquier, L. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.10.001 · Cited by 337 · see citing works

NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80.

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Major Histocompatibility Complex Class I–Recognizing Receptors Are Disease Risk Genes in Rheumatoid Arthritis

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Cutting Edge: Susceptibility to Psoriatic Arthritis: Influence of Activating Killer Ig-Like Receptor Genes in the Absence of Specific HLA-C Alleles

Martin, M. P., Nelson, G. W., Lee, J.-H., Pellett, F., Gao, X., Wade, J. A., Wilson, M. J., Trowsdale, J., Gladman, D. D., & Carrington, M. N. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.2818 · Cited by 328 · see citing works

Genetic and Functional Relationships between MHC and NK Receptor Genes

Trowsdale, J. (2001) · Immunity · doi:10.1016/s1074-7613(01)00197-2 · Cited by 321 · see citing works

Recognition of HLA‐A3 and HLA‐A11 by KIR3DL2 is peptide‐specific

Hansasuta, P., Dong, T., Thananchai, H., Weekes, M. P., Willberg, C. B., Aldemir, H., Rowland‐Jones, S., & Braud, V. M. (2004) · European Journal of Immunology · doi:10.1002/eji.200425089 · Cited by 319 · see citing works

The LILR family: modulators of innate and adaptive immune pathways in health and disease

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Complete MHC Haplotype Sequencing for Common Disease Gene MappingPreprint

Stewart, C. A., Horton, R., Allcock, R. J. N., Ashurst, J. L., Atrazhev, A. M., Coggill, P. C., Dunham, I., Forbes, S. A., Halls, K., Howson, J. M. M., et al. (2004) · Genome Research · doi:10.1101/gr.2188104 · Cited by 285 · see citing works

RECOGNITION BY γ/δ T CELLS

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Rapid Evolution of NK Cell Receptor Systems Demonstrated by Comparison of Chimpanzees and Humans

Khakoo, S. I., Rajalingam, R., Shum, B. P., Lienert-Weidenbach, K., Flodin, L. R., Muir, D. G., Canavez, F., Cooper, S., Valiante, N. M., Lanier, L. L., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)80219-8 · Cited by 277 · see citing works

Cutting Edge: Heterozygote Advantage in Autoimmune Disease: Hierarchy of Protection/Susceptibility Conferred by HLA and Killer Ig-Like Receptor Combinations in Psoriatic Arthritis

Nelson, G. W., Martin, M. P., Gladman, D. D., Wade, J. A., Trowsdale, J., & Carrington, M. N. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.7.4273 · Cited by 276 · see citing works

Allelic Polymorphism Synergizes with Variable Gene Content to Individualize Human KIR Genotype

Shilling, H. G., Guethlein, L. A., Cheng, N. W., Gardiner, C. M., Rodríguez, R., Tyan, D. B., & Parham, P. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.5.2307 · Cited by 273 · see citing works

KIR2DL4 (CD158d), an NK Cell-Activating Receptor with Inhibitory Potential

Faure, M., & Long, E. O. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6208 · Cited by 267 · see citing works

Different NK Cell Surface Phenotypes Defined by the DX9 Antibody Are Due to KIR3DL1 Gene Polymorphism

Gardiner, C. M., Guethlein, L. A., Shilling, H. G., Pando, M. J., Carr, W. H., Rajalingam, R., Vilches, C., & Parham, P. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.5.2992 · Cited by 264 · see citing works

Definition of gene content for nine common group B haplotypes of the Caucasoid population: KIR haplotypes contain between seven and eleven KIR genes

Uhrberg, M., Parham, P. R., & Wernet, P. (2002) · Immunogenetics · doi:10.1007/s00251-002-0463-7 · Cited by 263 · see citing works

Crucial Role of DNA Methylation in Determination of Clonally Distributed Killer Cell Ig-like Receptor Expression Patterns in NK Cells

Santourlidis, S., Trompeter, H., Weinhold, S., Eisermann, B., Meyer, K. L., Wernet, P., & Uhrberg, M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.8.4253 · Cited by 251 · see citing works

Genetic Control of Human NK Cell Repertoire

Shilling, H. G., Young, N. T., Guethlein, L. A., Cheng, N. W., Gardiner, C. M., Tyan, D. B., & Parham, P. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.239 · Cited by 245 · see citing works

The enigma of the natural killer cell

Gumperz, J. E., & Parham, P. R. (1995) · Nature · doi:10.1038/378245a0 · Cited by 233 · see citing works

KIR in Type 1 Diabetes

van der Slik, A. R., Koeleman, B. P. C., Verduijn, W., Bruining, G. J., Roep, B. O., & Giphart, M. J. (2003) · Diabetes · doi:10.2337/diabetes.52.10.2639 · Cited by 224 · see citing works

DNA Methylation Maintains Allele-specific KIR Gene Expression in Human Natural Killer Cells

Chan, H.-W., Kurago, Z., Stewart, C. A., Wilson, M. J., Martin, M. P., Mace, B. E., Carrington, M. N., Trowsdale, J., & Lutz, C. T. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021127 · Cited by 218 · see citing works

The Protein Made from a Common Allele of KIR3DL1 ( 3DL1*004 ) Is Poorly Expressed at Cell Surfaces due to Substitution at Positions 86 in Ig Domain 0 and 182 in Ig Domain 1

Pando, M. J., Gardiner, C. M., Gleimer, M., McQueen, K. L., & Parham, P. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.12.6640 · Cited by 211 · see citing works

Genetic Divergence of the Rhesus Macaque Major Histocompatibility ComplexPreprint

Daza-Vamenta, R., Glusman, G., Rowen, L., Guthrie, B. L., & Geraghty, D. E. (2004) · Genome Research · doi:10.1101/gr.2134504 · Cited by 211 · see citing works

Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA‐Cw4 molecules

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Activation of a Subset of Human NK Cells upon Contact with Plasmodium falciparum -Infected Erythrocytes

Artavanis‐Tsakonas, K., Eleme, K., McQueen, K. L., Cheng, N. W., Parham, P., Davis, D. M., & Riley, E. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.5396 · Cited by 197 · see citing works

Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression

Yawata, M., Yawata, N., McQueen, K. L., Cheng, N. W., Guethlein, L. A., Rajalingam, R., Shilling, H. G., & Parham, P. (2002) · Immunogenetics · doi:10.1007/s00251-002-0497-x · Cited by 196 · see citing works

Leukocyte Ig-like receptor complex (LRC) in mice and men

Martin, A. M., Kulski, J. K., Witt, C. S., Pontarotti, P., & Christiansen, F. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(01)02155-x · Cited by 186 · see citing works

KIR2DL4 Is an IL-2-Regulated NK Cell Receptor That Exhibits Limited Expression in Humans but Triggers Strong IFN-γ Production

Kikuchi-Maki, A., Yusa, S.-I., Catina, T. L., & Campbell, K. S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3415 · Cited by 183 · see citing works

Species‐specific evolution of MHC class I genes in the higher primates

Adams, E. J., & Parham, P. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1830104.x · Cited by 183 · see citing works

A structural perspective on MHC class I recognition by killer cell immunoglobulin-like receptors

Boyington, J. C., & Sun, P. D. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(02)00030-5 · Cited by 179 · see citing works

The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia

Cook, M. A., Milligan, D. W., Fegan, C., Darbyshire, P. J., Mahendra, P., Craddock, C., Moss, P. A. H., & Briggs, D. (2003) · Blood · doi:10.1182/blood-2003-02-0438 · Cited by 177 · see citing works

Differential binding to HLA-C of p50-activating and p58-inhibitory natural killer cell receptors

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IL‐21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig‐like receptors

Sivori, S., Cantoni, C., Parolini, S., Marcenaro, E., Conte, R., Moretta, L., & Moretta, A. (2003) · European Journal of Immunology · doi:10.1002/eji.200324533 · Cited by 173 · see citing works

Mini‐review: Defense strategies and immunity‐related genes

Trowsdale, J., & Parham, P. (2003) · European Journal of Immunology · doi:10.1002/eji.200324693 · Cited by 171 · see citing works

Demonstration of aberrant T‐cell and natural killer‐cell antigen expression in all cases of granular lymphocytic leukaemia

Morice, W. G., Kurtin, P. J., Leibson, P. J., Tefferi, A., & Hanson, C. A. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04201.x · Cited by 164 · see citing works

Variation Within the Human Killer Cell Immunoglobulin-Like Receptor ( KIR) Gene Family

Yawata, M., Yawata, N., Abi‐Rached, L., & Parham, P. (2002) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v22.i5-6.70 · Cited by 162 · see citing works

CD158k/KIR3DL2 Is a New Phenotypic Marker of Sezary Cells: Relevance for the Diagnosis and Follow-Up of Sezary Syndrome

Poszepczynska-Guigné, E., Schiavon, V., D'Incan, M., Echchakir, H., Musette, P., Ortonne, N., Boumsell, L., Moretta, A., Bensussan, A., & Bagot, M. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22326.x · Cited by 159 · see citing works

Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris

Łuszczek, W., Mańczak, M., Cisło, M., Nockowski, P., Wiśniewski, A., Jasek, M., & Kuśnierczyk, P. (2004) · Human Immunology · doi:10.1016/j.humimm.2004.05.008 · Cited by 155 · see citing works

Alloreactive killer cells: hindrance and help for haematopoietic transplants

Parham, P., & McQueen, K. L. (2003) · Nature reviews. Immunology · doi:10.1038/nri999 · Cited by 154 · see citing works

Relevance of KIR gene polymorphisms in bone marrow transplantation outcome

Gagne, K., Brizard, G., Gueglio, B., Milpied, N. J., Herry, P., Bonneville, F., Cheneau, M. L., SCHLEINITZ, N., Cesbron, A., Folléa, G., et al. (2002) · Human Immunology · doi:10.1016/s0198-8859(02)00373-7 · Cited by 150 · see citing works

A common KIR2DS4 deletion variant in the human that predicts a soluble KIR molecule analogous to the KIR1D molecule observed in the rhesus monkey

Maxwell, L. D., Wallace, A., Middleton, D., & Curran, M. D. (2002) · Tissue Antigens · doi:10.1034/j.1399-0039.2002.600307.x · Cited by 149 · see citing works

The beneficial role of inhibitory KIR genes of HLA class I NK epitopes in haploidentically mismatched stem cell allografts may be masked by residual donor‐alloreactive T cells causing GVHD

Bishara, A., Santis, D. D., Witt, C., Brautbar, C., Christiansen, F., Or, R., Nagler, A., & Slavin, S. (2004) · Tissue Antigens · doi:10.1111/j.0001-2815.2004.00182.x · Cited by 146 · see citing works

Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors

Bornhäuser, M., Schwerdtfeger, R., Martin, H., Frank, K., Theuser, C., & Ehninger, G. (2004) · Blood · doi:10.1182/blood-2003-11-3893 · Cited by 140 · see citing works

On the origins of the adaptive immune system: novel insights from invertebrates and cold-blooded vertebrates

Kasahara, M., Suzuki, T., & Pasquier, L. D. (2003) · Trends in Immunology · doi:10.1016/j.it.2003.11.005 · Cited by 138 · see citing works

Association of killer cell immunoglobulin‐like receptors with scleroderma

Momot, T., Koch, S., Hunzelmann, N., Krieg, T. M., Ulbricht, K. U., Schmidt, R. E., & Witte, T. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20216 · Cited by 137 · see citing works

The primary structure of HLA-A32 suggests a region involved in formation of the Bw4/Bw6 epitopes.

Wan, A. M., Ennis, P. D., Parham, P., & Holmes, N. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.11.3671 · Cited by 136 · see citing works

The Repertoire of Killer Cell Ig-Like Receptor and CD94:NKG2A Receptors in T Cells: Clones Sharing Identical αβ TCR Rearrangement Express Highly Diverse Killer Cell Ig-Like Receptor Patterns

Uhrberg, M., Valiante, N. M., Young, N. T., Lanier, L. L., Phillips, J. H., & Parham, P. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.6.3923 · Cited by 136 · see citing works

Genetic Polymorphisms of Killer Cell Immunoglobulin-Like Receptors Are Associated with Susceptibility to Psoriasis Vulgaris

Suzuki, Y., Hamamoto, Y., Ogasawara, Y., Ishikawa, K., Yoshikawa, Y., Sasazuki, T., & Muto, M. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22517.x · Cited by 135 · see citing works

Cutting Edge: Expansion of the KIR Locus by Unequal Crossing Over

Martin, M. P., Bashirova, A. A., Traherne, J. A., Trowsdale, J., & Carrington, M. N. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.5.2192 · Cited by 134 · see citing works

The ever‐expanding Ly49 gene family: repertoire and signaling

Anderson, S. K., Ortaldo, J. R., & McVicar, D. W. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1810106.x · Cited by 131 · see citing works

Comparative genomic analysis, diversity and evolution of two KIR haplotypes A and B

Martin, A. M., Kulski, J. K., Gaudieri, S., Witt, C. S., Freitas, E., Trowsdale, J., & Christiansen, F. (2004) · Gene · doi:10.1016/j.gene.2004.03.018 · Cited by 128 · see citing works

KIR2DL4 (CD158d) Genotype Influences Expression and Function in NK Cells

Goodridge, J. P., Witt, C. S., Christiansen, F., & Warren, H. S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.4.1768 · Cited by 126 · see citing works

Identification of natural killer cell receptor phenotypes associated with leukemia

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Single haplotype analysis demonstrates rapid evolution of the killer immunoglobulin-like receptor ( KIR ) loci in primatesPreprint

Sambrook, J. G., Bashirova, A. A., Palmer, S., Sims, S. K., Trowsdale, J., Abi‐Rached, L., Parham, P., Carrington, M. N., & Beck, S. (2005) · Genome Research · doi:10.1101/gr.2381205 · Cited by 124 · see citing works

Domain Shuffling Has Been the Main Mechanism Forming New Hominoid Killer Cell Ig-Like Receptors

Rajalingam, R., Parham, P., & Abi‐Rached, L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.1.356 · Cited by 115 · see citing works

Expression and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes

Zambello, R., Falco, M., Chiesa, M. D., Trentin, L., Carollo, D., Castriconi, R., Cannas, G., Carlomagno, S., Cabrelle, A., Lamy, T., et al. (2003) · Blood · doi:10.1182/blood-2002-12-3898 · Cited by 111 · see citing works

Meta-Analysis of Genome-Wide Studies of Psoriasis Susceptibility Reveals Linkage to Chromosomes 6p21 and 4q28–q31 in Caucasian and Chinese Hans Population

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Cutting Edge: Antibody-Dependent Memory-like NK Cells Distinguished by FcRγ Deficiency

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Crosstalk between decidual NK and CD14 + myelomonocytic cells results in induction of Tregs and immunosuppression

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KIR-ligand incompatibility in the graft-versus-host direction improves outcomes after umbilical cord blood transplantation for acute leukemia

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A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma

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Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice

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KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C

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Immunoporosis: Role of Innate Immune Cells in Osteoporosis

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Class I HLA haplotypes form two schools that educate NK cells in different ways

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IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect

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Cell-Cell Communication in the Tumor Microenvironment, Carcinogenesis, and Anticancer Treatment

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KIR2DL4 (CD158d): An activation receptor for HLA-G

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Expansion and enhanced survival of natural killer cells expressing the killer immunoglobulin‐like receptor KIR3DL2 in spondylarthritis

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NKp46 and NKG2D Recognition of Infected Dendritic Cells Is Necessary for NK Cell Activation in the Human Response to Influenza Infection

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Cutting Edge: Resistance to HIV-1 Infection among African Female Sex Workers Is Associated with Inhibitory KIR in the Absence of Their HLA Ligands

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Immunogenetics of NK Cell Receptors and MHC Class I Ligands in Non-human Primates

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MHC and KIR Polymorphisms in Rhesus Macaque SIV Infection

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