The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Integrating canonical and metabolic signalling programmes in the regulation of T cell responses
Open accessAbstract
Over the past decade, our understanding of T cell activation, differentiation and function has markedly expanded, providing a greater appreciation of the signals and pathways that regulate these processes. It has become clear that evolutionarily conserved pathways that regulate stress responses, metabolism, autophagy and survival have crucial and specific roles in regulating T cell responses. Recent studies suggest that the metabolic pathways involving MYC, hypoxia-inducible factor 1α (HIF1α), AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) are activated upon antigen recognition and that they are required for directing the consequences of T cell receptor engagement. The purpose of this Review is to provide an integrated view of the role of these metabolic pathways and of canonical T cell signalling pathways in regulating the outcome of T cell responses.
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Self-citationRegulation of innate immune cell function by mTOR
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Chen, J., Jiang, C. C., Jin, L., & Zhang, X. D. (2016) · Annals of Oncology · doi:10.1093/annonc/mdv615 · Cited by 767
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Metadata
- Authors
- Pollizzi, K. N., & Powell, J. D.
- Venue
- Nature Reviews Immunology
- Published
- 2014-06-25
- Volume
- 14
- Issue
- 7
- Pages
- 435-446
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2046959528
- Cited by
- 379
- References
- 127
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- green
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