The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.
Regulation of innate immune cell function by mTOR
Open accessAbstract
The innate immune system is central for the maintenance of tissue homeostasis and quickly responds to local or systemic perturbations by pathogenic or sterile insults. This rapid response must be metabolically supported to allow cell migration and proliferation and to enable efficient production of cytokines and lipid mediators. This Review focuses on the role of mammalian target of rapamycin (mTOR) in controlling and shaping the effector responses of innate immune cells. mTOR reconfigures cellular metabolism and regulates translation, cytokine responses, antigen presentation, macrophage polarization and cell migration. The mTOR network emerges as an integrative rheostat that couples cellular activation to the environmental and intracellular nutritional status to dictate and optimize the inflammatory response. A detailed understanding of how mTOR metabolically coordinates effector responses by myeloid cells will provide important insights into immunity in health and disease.
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1 retracted
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Cited by
AKT/PKB Signaling: Navigating the Network
Manning, B. D., & Toker, A. (2017) · Cell · doi:10.1016/j.cell.2017.04.001 · Cited by 3,772
A guide to immunometabolism for immunologists
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The PI3K Pathway in Human Disease
Fruman, D. A., Chiu, H., Hopkins, B. D., Bagrodia, S., Cantley, L. C., & Abraham, R. T. (2017) · Cell · doi:10.1016/j.cell.2017.07.029 · Cited by 2,749
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
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Targeting PI3K/Akt signal transduction for cancer therapy
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Metadata
- Authors
- Weichhart, T., Hengstschläger, M., & Linke, M.
- Venue
- Nature Reviews Immunology
- Published
- 2015-09-25
- Volume
- 15
- Issue
- 10
- Pages
- 599-614
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2210729715
- Cited by
- 830
- References
- 161
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- green
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