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Cited by 1,333RNA Research and SplicingDevelopmental Biology and Gene RegulationRNA regulation and disease

Alternative splicing as a regulator of development and tissue identity

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Baralle, Francisco E., Giudice, Jimena·2017·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm.2017.27PMC PMC6839889
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Abstract

Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a limited number of genes. The mechanisms and outcomes of alternative splicing of individual transcripts are relatively well understood, and recent efforts have been directed towards studying splicing networks. It has become apparent that coordinated splicing networks regulate tissue and organ development, and that alternative splicing has important physiological functions in different developmental processes in humans.

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  • RNA processing and miRNA-mediated gene silencing are fundamental mechanisms that fine-tune gene expression to regulate tissue development and physiology.

    “RNA processing and miRNA-mediated gene silencing are fundamental mechanisms that fine-tune gene expression to regulate tissue development and physiology (Kalsotra and Cooper 2011; Baralle and Giudice 2017; Bartel 2018; Marasco and Kornblihtt 2023)”

    From ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation (2025) · cites this paper as Baralle and Giudice 2017

    The Introduction states that alternative splicing contributes to tissue identity and organ development, supporting the RNA-processing part of the sentence. Our copy does not establish the broader claim about miRNA-mediated gene silencing; its References mention a specific miRNA that affects neuronal splicing, but not that general mechanism. (LLM, conf=0.85)

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Cited by

Sorted by citations

Authors
Baralle, F. E., & Giudice, J.
Affiliations
  • International Centre for Genetic Engineering and Biotechnology (IT)
  • University of North Carolina at Chapel Hill (US)
Corresponding author
Giudice, Jimena
ORCID
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2017-05-10
Volume
18
Issue
7
Pages
437-451
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
DOI
10.1038/nrm.2017.27
PMC
PMC6839889
OpenAlex
W2612976808
Cited by
1,333
References
15
Citations by year
2026: 107 · 2025: 179 · 2024: 169 · 2023: 180 · 2022: 207 · 2021: 189 · 2020: 152 · 2019: 91 · 2018: 53 · 2017: 5
FWCI
7.71
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056350)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords
alternative splicing, mRNA isoforms, proteome complexity, cell differentiation, tissue maturation, organogenesis, tissue homeostasis, tissue identity, developmental regulation
MeSH terms
Animals, Humans, Proteins, RNA, Messenger, Alternative Splicing

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