The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
AMPK: guardian of metabolism and mitochondrial homeostasis
Open accessAbstract
Cells constantly adapt their metabolism to meet their energy needs and respond to nutrient availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP levels via the serine/threonine kinase AMP-activated protein kinase (AMPK) complex. Under conditions of low energy, AMPK phosphorylates specific enzymes and growth control nodes to increase ATP generation and decrease ATP consumption. In the past decade, the discovery of numerous new AMPK substrates has led to a more complete understanding of the minimal number of steps required to reprogramme cellular metabolism from anabolism to catabolism. This energy switch controls cell growth and several other cellular processes, including lipid and glucose metabolism and autophagy. Recent studies have revealed that one ancestral function of AMPK is to promote mitochondrial health, and multiple newly discovered targets of AMPK are involved in various aspects of mitochondrial homeostasis, including mitophagy. This Review discusses how AMPK functions as a central mediator of the cellular response to energetic stress and mitochondrial insults and coordinates multiple features of autophagy and mitochondrial biology.
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Cites
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227
Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
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Self-citationAMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
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Self-citationTFEB Links Autophagy to Lysosomal Biogenesis
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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
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PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
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Mitochondrial TCA cycle metabolites control physiology and disease
Martínez-Reyes, I., & Chandel, N. S. (2020) · Nature Communications · doi:10.1038/s41467-019-13668-3 · Cited by 2,813
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Levine, B., & Kroemer, G. (2019) · Cell · doi:10.1016/j.cell.2018.09.048 · Cited by 2,832
mTOR at the nexus of nutrition, growth, ageing and disease
Liu, G. Y., & Sabatini, D. M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0199-y · Cited by 2,737
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
Sies, H., Belousov, V. V., Chandel, N. S., Davies, M. J., Jones, D. P., Mann, G. E., Murphy, M. P., Yamamoto, M., & Winterbourn, C. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00456-z · Cited by 1,735
Metadata
- Authors
- Herzig, S., & Shaw, R. J.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2017-10-04
- Volume
- 19
- Issue
- 2
- Pages
- 121-135
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2763871199
- Cited by
- 4,061
- References
- 68
- FWCI
- 12.48
- Type
- journal article
- Language
- en
- Open access
- green
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