Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all

Gil, Jesús, Peters, Gordon·2006·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm1987

Cited by (845)

Items 701–800 of 845

  1. Genetics of Coronary Disease
    Brian G. Kral, Lewis C. Becker · 2016 · Elsevier eBooks
  2. Association of long non-coding RNAs and ABO blood groups with acute lymphoblastic leukemia in Egyptian children
    Noha H. Sayed, Mahmoud Hammad, Safeya A. Abdelrahman, Hanan Muhammad Abdelgawad · 2024 · Non-coding RNA Research
  3. Biomarkers associated with cell-in-cell structure in kidney renal clear cell carcinoma based on transcriptome sequencing
    Zehua Wang, Zhongxiao Zhang · 2025 · PeerJ
  4. DNA methylation as a driver of lung fibroblast senescence in COPD
    Yin Lyu, Maaike de Vries, Martin Banchero, Victor Guryev, Wim Timens, Maarten van den Berge, Federica Sarno, Corry‐Anke Brandsma, Roy R. Woldhuis · 2025 · American Journal of Physiology-Lung Cellular and Molecular Physiology
  5. Interpreting the Origins and Functions of Noncoding RNAs From the Ribosomal Genes
    Tom Moss, Dany S. Sibai, Frédéric Lessard · 2025 · Journal of Cellular Physiology
  6. Senescence-associated and immune-related 9p21.3 locus genes in colorectal cancer: epigenetic architecture, molecular landscape and therapeutic possibilities
    Darya A. Lisitsa, Vadim V. Shindyapin, Artem R. Nurislamov, Oleg N. Demidov, Daria A. Bogdanova · 2026 · Frontiers in Cell and Developmental Biology
  7. Ginsenosides mitigate multi-organ aging: mechanistic insights from a preclinical systematic review and meta-analysis
    Ao Li, Hua‐Ze Wu, Die-Yi Chen, Yu‐Xin Gao, Xiao-Qiang Xiang, Qing‐Hui He, Hongyan Ma, Dan Tang · 2026 · Critical Reviews in Food Science and Nutrition
  8. The Molecular Mechanisms for Maintenance of Cancer Stem Cells in Chronic Myeloid Leukemia: A Dissertation
    Haojian Zhang · 2012 · The Journal of the American Medical Association (JAMA) Network (American Medical Association)
  9. Cancer, Senescence, and Aging: Translation from Basic Research to Clinics
    Matilde Esther LLeonart, Amancio Carnero, Rosanna Paciucci, Zhao‐Qi Wang, Noam Shomron · 2011 · Journal of Aging Research
  10. p53 as a Therapeutic Target in T-ALL
    Irene Riz, Wenjing Yang, Weiqun Peng, G. Robert · 2011 · InTech eBooks
  11. Comprehensive Mutation Analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1Genes is Suggestive of a Non- Neoplastic Nature of Phenytoin Induced Gingival Overgrowth
    Bhuminathan Swamikannu, Kishore S. Kumar, Raghavendra Jayesh, Senthilnathan Rajendran, Rajendran Shanmugam Muthupalani, Arvind Ramanathan · 2013 · Asian Pacific Journal of Cancer Prevention
  12. Epigenetics and viral infectious diseases
    Nikita Goyal, Vivek Morris Prathap, Anu Prakash · 2021 · Elsevier eBooks
  13. ANALYSIS OF THE ASSOCIATION OF RS4977574-POLYMORPHIC VARIANTS OF THE ANRIL GENE WITH THE DEVELOPMENT OF ACUTE CORONARY SYNDROME IN INDIVIDUALS WITH DIFFERENT BODY MASS INDEX IN THE UKRAINIAN POPULATION
    Polina V. Kniazkova, V. Yu. Harbuzova · 2022 · Eastern Ukrainian Medical Journal
  14. Role of Cyclin-Dependent Kinase Inhibitors (CKIs) as a Prognostic Biomarker for Cancer
    Md. Golam Hossain, Yearul Kabir · 2022 · Springer eBooks
  15. Insights Into Stem Cell Aging
    Antonio Herrera-Merchan, Isabel Hidalgo, Lorena Arranz, Susana González · 2012 · InTech eBooks
  16. GAPDH expression as a measurement of transfection efficiency for p16INK4a gene silencing (siRNA) in senescent human diploid fibroblasts
    Suzana Makpol, Azalina Zainuddin, Kien Hui Chua · 2012 · American Journal of Molecular Biology
  17. Genetic Variations of Long Noncoding RNAs in Cancer
    Nadya Dimitrova · 2017 · Elsevier eBooks
  18. Potential of the use of methylation biomarkers for diagnostics and prognosis of hepatocellular carcinoma in liquid biopsy
    Кустова Инна Феликсовна, Anna S. Makarova, Natalia L. Lazarevich · 2019 · Advances in molecular oncology
  19. Nutrigenomics of Aging
    Nelma M. Palminha, Sara A. Hashish, Eman Rabie, S. Saber · 2022 · Nutritional neurosciences
  20. CDK Inhibitors in Normal and Malignant Cells
    Alexander Besser, Joyce M. Slingerland · 2015 · Elsevier eBooks
  21. Molecular genetics and mechanisms of pigmentation and melanoma
    Elisabeth Sundström · 2010 · Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences))
  22. The role of polyhomeotic in polycomb group-mediatedregulation of the tumour suppressor P16INK4A
    L.A. de Breed · 2010 · UCL Discovery (University College London)
  23. Genetics of Coronary Heart Disease
    Michael S. Cunnington, Bernard D. Keavney · 2009
  24. The genetics of chronic myelogenous leukaemia
    Philippa C. May, Jamshid Sorouri Khorashad, Mary Alikian, Danilo Perrotti, Alistair G. Reid · 2016
  25. Senescence Induced by Repression of Human Papillomavirus Oncogenes in Cervical Cancer Cells
    Daniel DiMaio, Kimberly L. Johung, Edward C. Goodwin, Stacy M. Horner, Kristin E. Yates · 2008 · CRC Press eBooks
  26. Long non-coding RNAs (lncRNAs) and cardiovascular disease (CVD)
    Kenny C. Lam · 2019 · NORA - Norwegian Open Research Archives
  27. Cellular Senescence and Its Effects on Carcinogenesis
    Judith Campisi · 2008 · CRC Press eBooks
  28. Melanoma
    Jessie Villanueva, Meenhard Herlyn · 2009 · Encyclopedia of Life Sciences
  29. The Impact of TLR9 Expression Loss on Breast Cancer Tumor Cells
    Emily Sible, Gregory E. Weitsman, Salome Amoyal, Guillaume Roblot, Marie Marotel, Rémi Pescarmona, Nathalie Bendriss‐Vermare, Cheryl Gillet, Amie Ceesay, Marie‐Cécile Michallet et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  30. An atlas of genetic effects on the monocyte methylome across European and African populations
    Wan-Heng Zhang, Xiao Zhang, Chuan Qiu, Zi-Chen Zhang, Kuan-Jui Su, Zhe Luo, Minghui Liu, Bing-Xin Zhao, Lang Wu, Qing Tian et al. · 2024 · medRxiv
  31. Gene x lifestyle interactions in type 2 diabetes mellitus and related traits
    Ema C. Brito · 2010 · DiVA at Umeå University (Umeå University)
  32. Genetic biomarkers as prognostic and predictive factors in metastatic malignant melanoma
    Christian Busch · 2010 · NORA - Norwegian Open Research Archives
  33. Metýlering og DNA fjöldabreytingar á p16(INK4a) (CDKN2A) í stökum brjóstakrabbameinum
    Guðrún Birna Jónsdóttir · 2010
  34. Analysis of senescence-like growth arrest induced by RUNX1 and its fusion derived oncoproteins
    Kamil Wolyniec · 2008 · Enlighten: Theses (The University of Glasgow)
  35. Characterization of cdkn2b gene during zebrafish development
    Cátia Crespo · 2012 · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
  36. The regulation of RNA polymerase III-mediated transcription by p53, AP-1 and JNKs
    Sarah N. Dowding · 2013 · Enlighten: Theses (The University of Glasgow)
  37. Chromatin Structure in Cell Differentiation, Aging and Cancer
    Sima Kheradmand Kia · 2009
  38. Familial Melanoma in Italy: A Review
    Gloria Funari, Chiara Menin, Lisa Elefanti, Emma D’Andrea, Maria L. Dalla Chiara · 2011 · InTech eBooks
  39. Studies on Genetic Aberrations in Acute Myeloid Leukemia
    Saman Abbas · 2011 · EUR Research Repository (Erasmus University Rotterdam)
  40. Analysis of p53 and c-MYC, two key transcription factors involved in tumorigenesis
    Peter Jung · 2008
  41. Tone up your chromatin and stay young
    Navneet Kaur Matharu, Rakesh K. Mishra · 2011 · Journal of Biosciences
  42. Heterogeneous activation of p19Arf in pulmonary artery smooth muscle cells.
    V. Solodushko, D. Alvarez, R. Viator, T. Messerall, B. Fouty · 2011 · American Journal of Physiology - Lung cellular and Molecular Physiology
  43. Small molecules that affect the p53 pathway and their potential use in the treatment of cancer
    Marijke C.C. Sachweh · 2014 · Figshare
  44. Characterization of 𝘈𝘵𝘩𝘴𝘲1, an Atherosclerosis Modifier Locus on Mouse Chromosome 4:
    Chao-Ling Kuo · 2011
  45. Nuclear Factor of Activated T Cells Operates as Conductor of the Epigenetic Orchestra in Pancreatic Carcinogenesis
    Elisabeth Heßmann, Volker Ellenrieder · 2013 · Medical Epigenetics
  46. Characterization of the Visceral Endoderm Components in Early Post-Implantation Mouse Embryo Development: A Dissertation
    Tingting Huang · 2014 · eScholarship@UMassChan
  47. The thyrotropin receptor in thyroid carcinoma
    Guido C. Hovens · 2008 · Leiden Repository (Leiden University)
  48. Epigenetic modifications in caloric restriction associated with longevity: A review of evidence
    Hamid Zand, Fateme Sedaghat · 2015
  49. Glioblastoma Patients: p15 Methylation as a Prognostic Factor
    Steffi Urbschat, Silke Wemmert, Ralf Ketter · 2011 · Springer eBooks
  50. and Function in Maintaining Nucleolar Structure ARF p19Suppressor Role for Basal
    Jason D. Weber, José Luís Muñoz Sánchez, Anthony J. Saporita, Paula C. Miceli, Mary E. Olanich, J. Apicelli, Leonard B. Maggi, Angela C. Hirbe · 2014
  51. DESIGN AND SYNTHESIS OF NEW POLYCYCLIC COMPOUNDS WITH POTENTIAL ANTICANCER ACTIVITY
    Simona Musella · 2011
  52. Polycomb Group of Genes and the Epigenetics of Aging
    Krishnaveni Mishra, Rakesh K. Mishra · 2009 · Springer eBooks
  53. p27 Drives PI3K-dependent Cancer Metastasis by Activating EMT Transcription Factors to Induce an EMT Program
    Alexandra H. Besser · 2015
  54. The primary cilium as a regulator of cellular senescence in human fibroblasts
    Loretta Breslin · 2014 · ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway)
  55. The role of the transcription factor SRF in the inhibition of senescence in human and porcine smooth muscle cells
    Nina Konjer · 2009
  56. Genomische Aberrationen von synchron hepatisch metastasierten kolorektalen Karzinomen
    Carsten Mönkemeyer · 2011
  57. Contrôle de la signalisation oncogénique du mutant L858R de l'EGFR par la protéine
    Peggy Ozenne · 2011
  58. Molekularbiologie primär kutaner B-Zell-Lymphome
    Kjell Matthias Kaune · 2015 · Aktuelle Dermatologie
  59. The Roles and Mechanisms of Cellular Senescence: Obesity-induced Gut Microbial Metabolite Promotes Liver Cancer through Senescence Secretome
    Naoko Ohtani · 2015 · Journal of The Society of Japanese Women Scientists
  60. Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial No Derivative Works 3.0 Unported License, which permits distribution and reproduction in any medium, provided the originalauthorandsourcearecredited.Thislicensedoesnotpermitcommercialexploitationorthecreationofderivative works without specific permission.
    Goedele N. Maertens, Selma El Messaoudi, Sarah Elderkin, Kevin J. Hiom, Gordon G. Peters · 2010
  61. BASIC—ALIMENTARY TRACT Up-regulation of Activation-Induced Cytidine Deaminase Causes Genetic Aberrations at the CDKN2b-CDKN2a in Gastric Cancer
    Yuko Mizuno Matsumoto, Hiroyuki Marusawa, Kazuo Kinoshita, Yoko Niwa, Yoshiharu Sakai, Tsutomu Chiba · 2010
  62. Cellular Changes and Effects of Cytokines in the Transformation of Human Mammary Epithelial Cells
    Charlene E. Kan · 2009 · OhioLink ETD Center (Ohio Library and Information Network)
  63. Epigenetics and Cardiovascular Disease
    José Marı́n-Garcı́a · 2014 · Elsevier eBooks
  64. Cellular Senescence
    Judith Campisi · 2008 · Elsevier eBooks
  65. Causes and consequences of genomic instability in prostatic carcinogenesis.
    Anthony Michael Joshua · 2009 · TSpace (University of Toronto)
  66. Cellular Senescence as a Novel Mechanism of Chronic Inflammation and Cancer Progression
    Naoko Ohtani · 2016 · Springer eBooks
  67. Disruptive chemicals, senescence and immortality
    Fernandez Almagro, Sakyo-ku Kyoto · 2015
  68. Defining clinically relevant subgroups of follicular lymphoma cases according to the functional status of the CDKN2A gene
    Abdulmohsen Alhejaily · 2013 · QSpace (Queen's University Library)
  69. Apoptozis ve hücre döngüsü
    H Aktuğ · 2014 · Ege Tıp Dergisi
  70. Coordinating Cell Cycle Exit and Differentiation in the Mammalian Retina and its Dependence on Rb
    Marek Pacal · 2012 · TSpace (University of Toronto)
  71. The role of MITF in the regulation of CDKN2A in melanoma
    Randi Christel Andreassen · 2017 · NORA - Norwegian Open Research Archives
  72. Implications of Long Noncoding RNAs in Cancer Epigenetics
    Tianqi Yang, Yuming Shi, Eda Yildirim · 2017 · Elsevier eBooks
  73. Functional analysis of long non-coding RNAs in cancer
    Linda Vidarsdóttir · 2017 · Figshare
  74. PROGNOSTIC VALUE OF COMBINED IMMUNOHISTOCHEMICAL EXPRESSION OF BMI1 AND EZH2 IN ASTROCYTOMA
    Lobna Abdelsalam, Yehia Ali, Kamal ElKashishy, Eman Nour Eldeen · 2017 · Zagazig University Medical Journal
  75. Efecto de la administración de PPI-2458 sobre los procesos de proliferación celular y apoptosis en un modelo in vitro de hepatocarcinoma = Effect of treatment with PPI-2458 on cell proliferation and apoptosis processes in an in vitro model of Hepatocarcinoma
    Javier Martín‐Renedo · 2011
  76. Gene Profiling and Therapy: What's the Future? A Case Report of Uterine Leiomyosarcoma
    Alessia Re, A.R. Alitto, Ciro Mazzarella, Francesco Catucci, Antonella Martino, Giovanna Mantini, Giovanni Palazzoni · 2019 · Gynecology & Obstetrics
  77. Transcriptional regulation of ARF tumor suppressor
    Yaxue Zeng · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  78. Epigenomic reprogramming of caloric restriction on aging
    S. Ribarič · 2019 · Nutritional Epigenomics
  79. Testis-specific Arf promoter expression in a transposase-aided BAC transgenic mouse model
    Caroline Y. Sung, Yen‐Ting Liu, Lynda B. Bennett, Caitlin C. Devitt, Stephen X. Skapek · 2019 · Molecular Biology Reports
  80. ANALYSIS OF ASSOCIATION BETWEEN ANRIL GENE POLYMORPHISM AND KIDNEY CANCER DEVELOPMENT IN SMOKERS
    А. D. Volkogon, O. A. Obukhova, V. Yu. Harbuzova, Олександр Васильович Атаман · 2019 · Bulletin of Problems Biology and Medicine
  81. Investigating competitive interactions between normal and transformed neural stem cells
    Katerina Lawlor · 2019
  82. Genetic markers in neuroblastoma
    Georgi Nikolaev Valchev · 2019 · Varna Medical Forum
  83. Protein kinase D1 phosphorylates CBX8 to facilitate the disassociation of PRC1 complex from p16 promoter and promotes cell senescence
    Yuanyuan Su, Yao Liang, Chenzhong Xu, Na Zhang, Doudou Liu, Guodong Li, Tanjun Tong, Jun Chen · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  84. Investigational new drugs against glioblastoma
    David Olayinka. Kamson, Harmon Singh Khela, John Laterra · 2021 · Elsevier eBooks
  85. TGF-beta Signaling in Prostate Cancer
    Glen A. Bjerke · 2013
  86. Clinical-grade human umbilical cord-derived mesenchymal stem cells reverse skeletal muscle dysfunction in age-associated sarcopenia mice
    Yi Jia, Ailing Wang, Chao Wang, Jinglei Zhai, Bichun Zhao, Tuling Liao, Ning Cao, Ruyu Su, Lijuan He, Yanhua Li et al. · 2022 · Research Square
  87. INK4A
    Takehiko Kamijo · 2017 · Springer eBooks
  88. CDK4
    Stacey J. Baker, E. Premkumar Reddy · 2017 · Springer eBooks
  89. INK4a
    Takehiko Kamijo · 2008 · Springer eBooks
  90. CDK4
    Stacey J. Baker, E. Premkumar Reddy · 2017 · Springer eBooks
  91. INK4A
    Takehiko Kamijo · 2014 · Springer eBooks
  92. Molecular tumorigenesis of the skin
    Yoshiaki Kubo, Yoshihiro Matsudate, Nozomi Fukui, Ayaka Nakasuka, Maiko Sogawa, Mika Oshima, Tomoya Mizutani, Masanobu Otsu, Kazutoshi Murao, Ichiro Hashimoto · 2000 · The Journal of Medical Investigation
  93. INK4A
    Takehiko Kamijo · 2011 · Springer eBooks
  94. PROGNOSTIC VALUE OF COMBINED IMMUNOHISTOCHEMICAL EXPRESSION OF BMI1 AND EZH2 IN ASTROCYTOMA
    Lobna Abdelsalam, Yehia Ali, Kamal ElKashishy, Eman Nour Eldeen · 2013 · Zagazig University Medical Journal
  95. Faculty Opinions recommendation of The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis.
    Fabrizio d’Adda di Fagagna, Muege Ogrunc · 2013 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  96. CDK Inhibitors in Normal and Malignant Cells
    Alexandra H. Besser, Joyce M. Slingerland · 2022 · Elsevier eBooks
  97. The INK4α/ARF Locus
    Dawn E. Quelle, Jackson Nteeba, Benjamin W. Darbro · 2016 · Elsevier eBooks
  98. Data from Intrahepatic Cholangiocarcinoma with Lymph Node Metastasis: Treatment-Related Outcomes and the Role of Tumor Genomics in Patient Selection
    Joshua S. Jolissaint, Kevin C. Soares, Kenneth P. Seier, Ritika Kundra, Mithat Gönen, Paul J. Shin, Thomas Boerner, Carlie Sigel, Ramyasree Madupuri, Efsevia Vakiani et al. · 2023
  99. voyAGEr: free web interface for the analysis of age-related gene expression alterations in human tissues
    Arthur L. Schneider, Nuno Saraiva-Agostinho, Nuno L. Barbosa‐Morais · 2023 · eLife
  100. Expression analysis of cytoskeleton regulator RNA and Cyclin Dependent Kinase Inhibitor 2B genes in breast cancer
    Majid Mokhtari, Mahdi Gholipour, Solat Eslami, Atefe Abak, Bashdar Mahmud Hussen, Azadeh Rakhshan, Soudeh Ghafouri‐Fard · 2023 · Human Antibodies