What's taking so long? S-phase entry from quiescence versus proliferation
Abstract
There is a short window in the mammalian cell cycle during which cells can respond to extracellular cues by withdrawing temporarily from the cell cycle. When these cells re-enter the cell cycle, they require several extra hours in the G1 phase before they replicate their DNA compared with their cycling counterparts. More than 20 years after this initial observation, we still do not understand what is taking so long.
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Growth factors repress inhibitors and activate the G1/S transition to allow cell cycle entry.
“To allow cell cycle entry, growth factors repress these inhibitors and activate the G1/S transition (3).”
From Wnt signaling regulates hepatocyte cell division by a transcriptional repressor cascade (2022) · cites this paper as [3]
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Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908 · see citing works
The role of nuclear lamin B1 in cell proliferation and senescence
Shimi, T., Butin-Israeli, V., Adam, S. A., Hamanaka, R. B., Goldman, A. E., Lucas, C. A., Shumaker, D. K., Kosak, S. T., Chandel, N. S., & Goldman, R. D. (2011) · Genes & Development · doi:10.1101/gad.179515.111 · Cited by 547 · see citing works
DNA replication stress, genome instability and aging
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HGFA is an injury-regulated systemic factor that induces the transition of stem cells into GAlert
Rodgers, J. T., Schroeder, M. D., Ma, C., & Rando, T. A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.066 · Cited by 161 · see citing works
Dulic, V. (2013) · Methods in Molecular Biology · doi:10.1007/978-1-62703-239-1_2 · Cited by 42 · see citing works
Wnt signaling regulates hepatocyte cell division by a transcriptional repressor cascade
Jin, Y., Anbarchian, T., Wu, P., Sarkar, A., Fish, M., Peng, W. C., & Nusse, R. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2203849119 · Cited by 26 · see citing works
“To allow cell cycle entry, growth factors repress these inhibitors and activate the G1/S transition (3).”
BackgroundJin, Y., Anbarchian, T., Wu, P., Sarkar, A., Fish, M., & Nusse, R. (2021) · doi:10.1101/2021.10.15.464616 · Cited by 2 · see citing works
- Authors
- Coller, H. A.
- Affiliations
- Princeton University (US)
- Corresponding author
- Coller, Hilary A.
- ORCID
- Coller, Hilary A.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2007-08
- Volume
- 8
- Issue
- 8
- Pages
- 667-670
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1977355826
- Cited by
- 116
- References
- 2
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 8 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 5 · 2012: 11
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- S phase entry, cell cycle quiescence, pre-replication complex, chromatin, cell cycle withdrawal, cell cycle re-entry, DNA replication timing, mammalian cell cycle
- MeSH terms
- Animals, DNA Replication, Humans, Time Factors, G1 Phase, S Phase
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