The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
The RSK family of kinases: emerging roles in cellular signalling
Abstract
The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases that regulate diverse cellular processes, such as cell growth, cell motility, cell survival and cell proliferation. RSKs are downstream effectors of the Ras-extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signalling cascade. Significant advances in the field of RSK and ERK/MAPK signalling have occurred in the past few years, including biological insights and the discovery of novel substrates and new RSK regulatory mechanisms. Collectively, these data expand the current models of RSK signalling and highlight potential directions of research in RSK-mediated survival, growth, proliferation and migration.
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“MSKs, similarly to MNKs, can also be activated by both MAPKs whereas RSKs are generally thought to be the substrate of ERKs (28) (Fig. 2B).”
From Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove (2012) · cites this paper as [28]
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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stabilityPreprint
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Nicklin, P., Bergman, P., Zhang, B., Triantafellow, E., Wang, H., Nyfeler, B., Yang, H., Hild, M., Kung, C., Wilson, C., et al. (2009) · Cell · doi:10.1016/j.cell.2008.11.044 · Cited by 1,798
ERK1/2 MAP kinases: Structure, function, and regulation
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ERK/MAPK signalling pathway and tumorigenesis (Review)
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Metadata
- Authors
- Anjum, R., & Blenis, J.
- Affiliations
- Harvard University (US)
- Corresponding author
- Blenis, John
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2008-10
- Volume
- 9
- Issue
- 10
- Pages
- 747-758
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2042625441
- Cited by
- 777
- References
- 124
- Citations by year
- 2026: 22 · 2025: 35 · 2024: 23 · 2023: 52 · 2022: 34 · 2021: 38 · 2020: 37 · 2019: 30 · 2018: 39 · 2017: 42 · 2016: 39 · 2015: 56 · 2014: 52 · 2013: 57 · 2012: 64
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- RSK, RAS/MAPK pathway, serine/threonine kinase, cell proliferation, cell migration, cell survival, cell growth
- MeSH terms
- Amino Acid Sequence, Animals, Binding Sites, Cell Cycle, Cell Survival, Enzyme Activation, Humans, Models, Biological, Models, Molecular, Molecular Sequence Data, Phosphorylation, Transcription, Genetic, Protein Biosynthesis, Sequence Homology, Amino Acid, Protein Structure, Tertiary, MAP Kinase Signaling System, Ribosomal Protein S6 Kinases, 90-kDa
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