The RSK family of kinases: emerging roles in cellular signalling

AKT/PKB signaling: navigating downstream

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Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

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ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions

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The selectivity of protein kinase inhibitors: a further update

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Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

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The renaissance of GSK3

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Gene silencing in mammals by small interfering RNAs

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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

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mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events

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Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

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Nuclear Localization and Regulation of erk- and rsk-Encoded Protein Kinases

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

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Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

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Mitogen‐ and stress‐activated protein kinase‐1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

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Molecular interpretation of ERK signal duration by immediate early gene products

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Inactivation of glycogen synthase kinase-3 β by phosphorylation: new kinase connections in insulin and growth-factor signalling

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ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

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Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase

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PDK1, the master regulator of AGC kinase signal transduction

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Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

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S6K1 −/− / S6K2 −/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

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Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB

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Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction

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RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation

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Bidirectional RNA Helicase Activity of Eucaryotic Translation Initiation Factors 4A and 4F

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Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.

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c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor MiPreprint

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The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

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MSK2 and MSK1 mediate the mitogen‐ and stress‐induced phosphorylation of histone H3 and HMG‐14

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Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors

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The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

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Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

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Silencing of Epidermal Growth Factor Receptor Suppresses Hypoxia-Inducible Factor-2–Driven VHL −/− Renal Cancer

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MSK1 and MSK2 Are Required for the Mitogen- and Stress-Induced Phosphorylation of CREB and ATF1 in Fibroblasts

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Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals.

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Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome

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Identification of Regulatory Phosphorylation Sites in Mitogen-activated Protein Kinase (MAPK)-activated Protein Kinase-1a/p90 That Are Inducible by MAPK

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Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation

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pp90rsk1 Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167

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A link between MAP kinase and p34cdc2/cyclin B during oocyte maturation: p90rsk phosphorylates and inactivates the p34cdc2 inhibitory kinase Myt1

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A phosphoserine‐regulated docking site in the protein kinase RSK2 that recruits and activates PDK1

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BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

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Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c- fos gene

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Rsk1 mediates a MEK–MAP kinase cell survival signal

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Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase.

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Identification of the First Specific Inhibitor of p90 Ribosomal S6 Kinase (RSK) Reveals an Unexpected Role for RSK in Cancer Cell Proliferation

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Identification of an Extracellular Signal-regulated Kinase (ERK) Docking Site in Ribosomal S6 Kinase, a Sequence Critical for Activation by ERK in Vivo

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A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases.

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A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

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90-kDa Ribosomal S6 Kinase Is Phosphorylated and Activated by 3-Phosphoinositide-dependent Protein Kinase-1

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ERK-Dependent Phosphorylation of the Transcription Initiation Factor TIF-IA Is Required for RNA Polymerase I Transcription and Cell Growth

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Regulation of the meiotic cell cycle in oocytes

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The Signal-Dependent Coactivator CBP Is a Nuclear Target for pp90RSK

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Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1

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p90RSK Blocks Bad-mediated Cell Death via a Protein Kinase C-dependent Pathway

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p90RSK Is a Serum-stimulated Na+/H+ Exchanger Isoform-1 Kinase

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IκBα is a target for the mitogen‐activated 90 kDa ribosomal S6 kinase

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Mitogen- and Stress-Activated Protein Kinase 1 Mediates cAMP Response Element-Binding Protein Phosphorylation and Activation by Neurotrophins

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The RSK factors of activating the Ras/MAPK signaling cascade

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Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization

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The Serine/Threonine Protein Kinase, p90 Ribosomal S6 Kinase, Is an Important Regulator of Prostate Cancer Cell Proliferation

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Evidence for Two Catalytically Active Kinase Domains in pp90 rsk

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Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity

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A protein kinase from Xenopus eggs specific for ribosomal protein S6.

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MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells

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Glycogen synthase kinase 3 phosphorylates Jun family members in vitro and negatively regulates their transactivating potential in intact cells.

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Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

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Ribosomal S6 Kinase (RSK) Regulates Phosphorylation of Filamin A on an Important Regulatory Site

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Signaling control of mRNA translation in cancer pathogenesis

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The Protein Kinase p90 Rsk as an Essential Mediator of Cytostatic Factor Activity

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RSK-B, a Novel Ribosomal S6 Kinase Family Member, Is a CREB Kinase under Dominant Control of p38α Mitogen-activated Protein Kinase (p38αMAPK)

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C/EBPβ Phosphorylation by RSK Creates a Functional XEXD Caspase Inhibitory Box Critical for Cell Survival

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MSK1 activity is controlled by multiple phosphorylation sites

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The Tumor Suppressor DAP Kinase Is a Target of RSK-Mediated Survival Signaling

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Increased phosphorylation of ribosomal protein S6 during meiotic maturation of Xenopus oocytes.

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FGFR3 Activates RSK2 to Mediate Hematopoietic Transformation through Tyrosine Phosphorylation of RSK2 and Activation of the MEK/ERK Pathway

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Induction of Metaphase Arrest in Cleaving Xenopus Embryos by the Protein Kinase p90 Rsk

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RSK3 Encodes a Novel pp90 rsk Isoform with a Unique N-Terminal Sequence: Growth Factor-Stimulated Kinase Function and Nuclear Translocation

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The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

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Altered Extracellular Signal-Regulated Kinase Signaling and Glycogen Metabolism in Skeletal Muscle from p90 Ribosomal S6 Kinase 2 Knockout Mice

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Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK

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Identification of insulin‐stimulated protein kinase‐1 as the rabbit equivalent of rskmo‐2

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A direct link of the Mos–MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopus laevis eggs

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The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

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Functional Characterization of Human RSK4, a New 90-kDa Ribosomal S6 Kinase, Reveals Constitutive Activation in Most Cell Types

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