Blenis, John

Molecular mechanisms of mTOR-mediated translational control

Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 2,558

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

Mendoza, M. C., Er, E. E., & Blenis, J. (2011) · Trends in Biochemical Sciences

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 1,817

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., & Cantley, L. C. (2002) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerTuberous Sclerosis Complex Research

Cited by 1,555

Rapamycin: one drug, many effects

Li, J., Kim, S. G., & Blenis, J. (2014) · Cell Metabolism

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 1,287

mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events

Holz, M. K., Ballif, B. A., Gygi, S. P., & Blenis, J. (2005) · Cell

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 1,262

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

Fingar, D. C., Salama, S., Tsou, C., Harlow, E., & Blenis, J. (2002) · Genes & Development

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 1,093

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

Tee, A. R., Fingar, D. C., Manning, B. D., Kwiatkowski, D. J., Cantley, L. C., & Blenis, J. (2002) · Proceedings of the National Academy of Sciences

PI3K/AKT/mTOR signaling in cancerTuberous Sclerosis Complex Research

Cited by 827

The RSK family of kinases: emerging roles in cellular signalling

Anjum, R., & Blenis, J. (2008) · Nature Reviews Molecular Cell Biology

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 777

An atlas of substrate specificities for the human serine/threonine kinome

Johnson, J. L., Yaron, T. M., Huntsman, E. M., Kerelsky, A., Song, J., Regev, A., Lin, T.-Y., Liberatore, K., Cizin, D. M., Cohen, B. M., et al. (2023) · Nature

Advanced Proteomics Techniques and ApplicationsProtein Kinase Regulation and GTPase Signaling

Cited by 728

Mapk signal specificity: The right place at the right time

Murphy, L. O., & Blenis, J. (2006) · Trends in Biochemical Sciences

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 707

STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

Chung, J., Uchida, E., Grammer, T. C., & Blenis, J. (1997) · Molecular and Cellular Biology

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 620

Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules

Verhey, K. J., Meyer, D., Deehan, R., Blenis, J., Schnapp, B. J., Rapoport, T. A., & Margolis, B. (2001) · The Journal of Cell Biology

Microtubule and mitosis dynamicsProtein Kinase Regulation and GTPase Signaling

Cited by 609

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

Csibi, A., Fendt, S.-M., Li, C., Poulogiannis, G., Choo, A. Y., Chapski, D. J., Jeong, S. M., Dempsey, J. M., Parkhitko, A., Morrison, T., et al. (2013) · Cell

PI3K/AKT/mTOR signaling in cancerCancer, Hypoxia, and Metabolism

Cited by 586

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

Jeong, S. M., Xiao, C., Finley, L. W. S., Lahusen, T., Souza, A. L., Pierce, K., Li, Y.-H., Wang, X., Laurent, G., German, N. J., et al. (2013) · Cancer Cell

Sirtuins and Resveratrol in MedicineCancer, Hypoxia, and Metabolism

Cited by 445

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

Mullarky, E., Lucki, N. C., Beheshti Zavareh, R., Anglin, J. L., Gomes, A. P., Nicolay, B. N., Wong, J. C. Y., Christen, S., Takahashi, H., Singh, P. K., et al. (2016) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 333

The 70 kDa S6 Kinase Complexes with and Is Activated by the Rho Family G Proteins Cdc42 and Rac1

Chou, M. M., & Blenis, J. (1996) · Cell

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 292

Age-induced accumulation of methylmalonic acid promotes tumour progression

Gomes, A. P., Ilter, D., Low, V., Endress, J. E., Fernández-García, J., Rosenzweig, A., Schild, T., Broekaert, D., Ahmed, A., Planque, M., et al. (2020) · Nature

Cancer, Lipids, and MetabolismGenetics, Aging, and Longevity in Model Organisms

Cited by 244

Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex

Kim, S. G., Hoffman, G. R., Poulogiannis, G., Buel, G. R., Jang, Y. J., Lee, K. W., Kim, B.-Y., Erikson, R. L., Cantley, L. C., Choo, A. Y., et al. (2013) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 215

ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex

Mendoza, M. C., Er, E. E., Zhang, W., Ballif, B. A., Elliott, H. L., Danuser, G., & Blenis, J. (2011) · Molecular Cell

Cellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 169

mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-dependent Foxk1 Phosphorylation

He, L., Gomes, A. P., Wang, X., Yoon, S. O., Lee, G., Nagiec, M. J., Cho, S., Chavez, A., Islam, T., Yu, Y., et al. (2018) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 145

Spatially Separate Docking Sites on ERK2 Regulate Distinct Signaling Events In Vivo

Dimitri, C. A., Dowdle, W., MacKeigan, J. P., Blenis, J., & Murphy, L. O. (2005) · Current Biology

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 114

A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways

Gomes, A. P., & Blenis, J. (2015) · Current Opinion in Biotechnology

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 112

Beyond the Warburg effect: How do cancer cells regulate one-carbon metabolism?

Rosenzweig, A., Blenis, J., & Gomes, A. P. (2018) · Frontiers in Cell and Developmental Biology

Cancer, Hypoxia, and MetabolismFolate and B Vitamins Research

Cited by 107

Altered propionate metabolism contributes to tumour progression and aggressiveness

Gomes, A. P., Ilter, D., Low, V., Drapela, S., Schild, T., Mullarky, E., Han, J., Elia, I., Broekaert, D., Rosenzweig, A., et al. (2022) · Nature Metabolism

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 104