Crosstalk between small GTPases and polarity proteins in cell polarization
Abstract
Cell polarization is crucial for the development of multicellular organisms, and aberrant cell polarization contributes to various diseases, including cancer. How cell polarity is established and how it is maintained remain fascinating questions. Conserved proteins of the partitioning defective (PAR), Scribble and Crumbs complexes guide the establishment of cell polarity in various organisms. Moreover, GTPases that regulate actin cytoskeletal dynamics have been implicated in cell polarization. Recent findings provide insights into polarization mechanisms and show intriguing crosstalk between small GTPases and members of polarity complexes in regulating cell polarization in different cellular contexts and cell types.
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Rock and Pak are two kinases that can be activated respectively by Rho and Cdc42.
“Amongst known effectors of Rho and Cdc42, Rock and Pak are two kinases that can be activated repsectively by these GTPases24–26.”
From Local, persistent activation of Rho GTPases during plasticity of single dendritic spines (2011) · cites this paper as [26]
Cites
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The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling
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- Authors
- Iden, S., & Collard, J. G.
- Affiliations
- The Netherlands Cancer Institute (NL)
- ORCID
- Iden, Sandra
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2008-11
- Volume
- 9
- Issue
- 11
- Pages
- 846-859
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2033555492
- Cited by
- 451
- References
- 7
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 11 · 2023: 2 · 2022: 17 · 2021: 10 · 2020: 15 · 2019: 18 · 2018: 29 · 2017: 30 · 2016: 32 · 2015: 36 · 2014: 37 · 2013: 47 · 2012: 62
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- KWF Kankerbestrijding
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- cell polarization, small GTPases, Par complex, Crumbs complex, actin cytoskeleton, crosstalk, cancer, multicellular development
- MeSH terms
- Animals, Cell Movement, Cytoskeleton, Humans, Proteins, Cell Polarity, Monomeric GTP-Binding Proteins
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