Cited by 1,137Gene Regulatory Network AnalysisCircadian rhythm and melatoninNonlinear Dynamics and Pattern Formation

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Design principles of biochemical oscillators

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Novák, Béla, Tyson, John J.·2008·Nature Reviews Molecular Cell Biology

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Abstract

Cellular rhythms are generated by complex interactions among genes, proteins and metabolites. They are used to control every aspect of cell physiology, from signalling, motility and development to growth, division and death. We consider specific examples of oscillatory processes and discuss four general requirements for biochemical oscillations: negative feedback, time delay, sufficient 'nonlinearity' of the reaction kinetics and proper balancing of the timescales of opposing chemical reactions. Positive feedback is one mechanism to delay the negative-feedback signal. Biological oscillators can be classified according to the topology of the positive- and negative-feedback loops in the underlying regulatory mechanism.

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Authors: Novák, B., & Tyson, J. J.
Affiliations: University of Oxford (GB)
Virginia Tech (US)
Corresponding author: Novák, Béla
ORCID: Novák, Béla
Tyson, John J.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2008-10-30
Volume: 9
Issue: 12
Pages: 981-991
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm2530
PMC: PMC2796343
OpenAlex: W2030945597
Cited by: 1,137
References: 72
Citations by year: 2026: 56 · 2025: 56 · 2024: 71 · 2023: 52 · 2022: 77 · 2021: 80 · 2020: 79 · 2019: 67 · 2018: 81 · 2017: 69 · 2016: 60 · 2015: 57 · 2014: 65 · 2013: 62 · 2012: 72
FWCI: 3.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5r01gm078989-13)
Biotechnology and Biological Sciences Research Council
National Institute of General Medical Sciences (R01-GM078989, R01GM079207)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Nonlinear Dynamics and Pattern Formation
Keywords: biochemical oscillators, cellular rhythms, negative feedback, time delay, positive feedback, gene regulatory networks, oscillations
MeSH terms: Animals, Biological Clocks, Circadian Rhythm, Kinetics, Models, Biological, Signal Transduction, Feedback, Physiological

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