The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Ion channels versus ion pumps: the principal difference, in principle
Open accessAbstract
The incessant traffic of ions across cell membranes is controlled by two kinds of border guards: ion channels and ion pumps. Open channels let selected ions diffuse rapidly down electrical and concentration gradients, whereas ion pumps labour tirelessly to maintain the gradients by consuming energy to slowly move ions thermodynamically uphill. Because of the diametrically opposed tasks and the divergent speeds of channels and pumps, they have traditionally been viewed as completely different entities, as alike as chalk and cheese. But new structural and mechanistic information about both of these classes of molecular machines challenges this comfortable separation and forces its re-evaluation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418
Smith, P. C., Karpowich, N., Millen, L., Moody, J. E., Rosen, J., Thomas, P. J., & Hunt, J. F. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00576-2 · Cited by 773
Cited by
Anion transport and supramolecular medicinal chemistry
Gale, P. A., Davis, J. T., & Quesada, R. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00159b · Cited by 359
Muller, M. P., Jiang, T., Sun, C., Lihan, M., Pant, S., Mahinthichaichan, P., Trifan, A., & Tajkhorshid, E. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00608 · Cited by 282
Structure, Gating, and Regulation of the CFTR Anion Channel
Csanády, L., Vergani, P., & Gadsby, D. C. (2019) · Physiological Reviews · doi:10.1152/physrev.00007.2018 · Cited by 262
Self-citationStructure of the CLC-1 chloride channel from Homo sapiens
Park, E., & MacKinnon, R. (2018) · eLife · doi:10.7554/elife.36629 · Cited by 109
Molecular mechanism of proton transport in CLC Cl - /H + exchange transporters
Feng, L., Campbell, E. B., & MacKinnon, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205764109 · Cited by 82
Metadata
- Authors
- Gadsby, D. C.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2009-04-02
- Volume
- 10
- Issue
- 5
- Pages
- 344-352
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1983398269
- Cited by
- 524
- References
- 2
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Ion channels versus ion pumps: the principal difference, in principle. https://app.cochat.ai/papers/10.1038/nrm2668
- The paper
- Gadsby, D. C. (2009). Ion channels versus ion pumps: the principal difference, in principle. Nature Reviews Molecular Cell Biology. https://doi.org/10.1038/nrm2668
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
