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The second wave of synthetic biology: from modules to systems
Abstract
Synthetic biology is a research field that combines the investigative nature of biology with the constructive nature of engineering. Efforts in synthetic biology have largely focused on the creation and perfection of genetic devices and small modules that are constructed from these devices. But to view cells as true 'programmable' entities, it is now essential to develop effective strategies for assembling devices and modules into intricate, customizable larger scale systems. The ability to create such systems will result in innovative approaches to a wide range of applications, such as bioremediation, sustainable energy production and biomedical therapies.
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“In contrast to classical approaches it is highly structured and biological networks are split into smaller functional modules [11,183], leading to complex optimization needs.”
From Adaptive laboratory evolution—Principles and applications for biotechnology (2013) · cites this paper as [11]
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Metadata
- Authors
- Purnick, P. E. M., & Weiss, R.
- Affiliations
- Princeton University (US)
- ORCID
- Weiss, Ron
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2009-06
- Volume
- 10
- Issue
- 6
- Pages
- 410-422
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2041985017
- Cited by
- 1,181
- References
- 125
- Citations by year
- 2026: 34 · 2025: 32 · 2024: 39 · 2023: 31 · 2022: 40 · 2021: 50 · 2020: 68 · 2019: 67 · 2018: 61 · 2017: 68 · 2016: 70 · 2015: 93 · 2014: 129 · 2013: 112 · 2012: 121
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Edinburgh
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Keywords
- synthetic biology, gene modules, systems biology, cell engineering, bioremediation, sustainable energy production, biomedical therapy
- MeSH terms
- Bacteria, Biology, Biotechnology, Cell Line, Computer Simulation, Engineering, Gene Expression Regulation, Humans, Models, Biological, Software, Genome, Nanotechnology, Epigenesis, Genetic, Gene Regulatory Networks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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