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Role of specialized DNA polymerases in the limitation of replicative stress and DNA damage transmission

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Replication stress in hematopoietic stem cells in mouse and man

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AKT signaling promotes DNA damage accumulation and proliferation in polycystic kidney disease

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When RAD52 Allows Mitosis to Accept Unscheduled DNA Synthesis

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A Noncanonical DNA Damage Checkpoint Response in a Major Fungal Pathogen

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Physical interactions between MCM and Rad51 facilitate replication fork lesion bypass and ssDNA gap filling by non-recombinogenic functions

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The Role of the Transcriptional Response to DNA Replication Stress

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Cohesin dynamic association to chromatin and interfacing with replication forks in genome integrity maintenance

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PROBING GENOME MAINTENANCE FUNCTIONS OF HUMAN RECQ1

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Overexpression of RFC3 is correlated with ovarian tumor development and poor prognosis

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Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles

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Cellular Dynamics of Rad51 and Rad54 in Response to Postreplicative Stress and DNA Damage in HeLa Cells

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Error‐free DNA damage tolerance pathway is facilitated by the Irc5 translocase through cohesin

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CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs

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Direct binding of Cdt2 to PCNA is important for targeting the CRL4 Cdt2 E3 ligase activity to Cdt1

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E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells

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Detection of PCNA Modifications in Saccharomyces cerevisiae

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Slx4 scaffolding in homologous recombination and checkpoint control: lessons from yeast

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A Novel Cell-Penetrating Antibody Fragment Inhibits the DNA Repair Protein RAD51

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Pluripotent stem cells with low differentiation potential contain incompletely reprogrammed DNA replication

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Checkpoint-mediated DNA polymerase ε exonuclease activity curbing counteracts resection-driven fork collapse

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Telomere healing following DNA polymerase arrest-induced breakages is likely the main mechanism generating chromosome 4p terminal deletions

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TIPIN depletion leads to apoptosis in breast cancer cells

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The Smc5-Smc6 heterodimer associates with DNA through several independent binding domains

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Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers

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FANC Pathway Promotes UV-Induced Stalled Replication Forks Recovery by Acting Both Upstream and Downstream Polη and Rev1

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BRCA2 gets protective at forks

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Back to the Origin: Reconsidering Replication, Transcription, Epigenetics, and Cell Cycle Control

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RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin

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Long-range heterochromatin association is mediated by silencing and double-strand DNA break repair proteins

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PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice

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PCNA Deubiquitylases Control DNA Damage Bypass at Replication Forks

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Importin β-dependent nuclear import of TopBP1 in ATR–Chk1 checkpoint in Xenopus egg extracts

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The Largest Subunit of DNA Polymerase Delta Is Required for Normal Formation of Meiotic Type I Crossovers

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In vivo DNA replication dynamics unveil aging-dependent replication stress

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Adenovirus E1A Oncogene Induces Rereplication of Cellular DNA and Alters DNA Replication Dynamics

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CNV instability associated with DNA replication dynamics: evidence for replicative mechanisms in CNV mutagenesis

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Chronic treatment with cisplatin induces replication-dependent sister chromatid recombination to confer cisplatin-resistant phenotype in nasopharyngeal carcinoma

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Histone H2B mono-ubiquitylation maintains genomic integrity at stalled replication forks

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Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability

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Nuclear actin and myosin in chromatin regulation and maintenance of genome integrity

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Co-inhibition of Pol η and ATR sensitizes cisplatin-resistant non-small cell lung cancer cells to cisplatin by impeding DNA damage repair

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JMJD-1.2 controls multiple histone post-translational modifications in germ cells and protects the genome from replication stress

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The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity

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APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage response

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Binding of Multiple Rap1 Proteins Stimulates Chromosome Breakage Induction during DNA Replication

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Shelterin components mediate genome reorganization in response to replication stress

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A UVR-induced G2-phase checkpoint response to ssDNA gaps produced by replication fork bypass of unrepaired lesions is defective in melanoma

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Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development

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Gene amplification system based on double rolling-circle replication as a model for oncogene-type amplification

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DNA damage checkpoint and recombinational repair differentially affect the replication stress tolerance ofsmc6mutants

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Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks

Weinheimer, A. S., Paung, Y., Rageul, J., Khan, A., Lo, N., Ho, B., Tong, M., Alphonse, S., Seeliger, M. A., & Kim, H. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102268 · Cited by 17

MDM2 Overexpression, Activation of Signaling Networks, and Cell Proliferation

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hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ

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RAD001 (everolimus) induces dose-dependent changes to cell cycle regulation and modifies the cell cycle response to vincristine

Saunders, P. O., Weiss, J., Welschinger, R., Baraz, R., Bradstock, K. F., & Bendall, L. J. (2012) · Oncogene · doi:10.1038/onc.2012.498 · Cited by 17

Synergism between bosutinib (SKI-606) and the Chk1 inhibitor (PF-00477736) in highly imatinib-resistant BCR/ABL+ leukemia cells

Nguyen, T., Hawkins, E., Kolluri, A., Kmieciak, M., Park, H., Lin, H., & Grant, S. (2014) · Leukemia Research · doi:10.1016/j.leukres.2014.10.009 · Cited by 17

Tipin Functions in the Protection against Topoisomerase I Inhibitor

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A genome-wide map of adeno-associated virus–mediated human gene targeting

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Nanoscale Assembly of High-Mobility Group AT-Hook 2 Protein with DNA Replication Fork

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Prevention of unwanted recombination at damaged replication forks

Lehmann, C. P., Jiménez-Martín, A., Branzei, D., & Tercero, J. A. (2020) · Current Genetics · doi:10.1007/s00294-020-01095-7 · Cited by 19

Replicating Damaged DNA in EukaryotesPreprint

Chatterjee, N., & Siede, W. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019836 · Cited by 17

Dealing with Transcriptional Outbursts during S Phase to Protect Genomic Integrity

Duch, A., de Nadal, E., & Posas, F. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.08.019 · Cited by 16

γH2A-Binding Protein Brc1 Affects Centromere Function in Fission Yeast

Lee, S. Y., Rozenzhak, S., & Russell, P. R. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01654-12 · Cited by 16

MicroRNA-34a promotes genomic instability by a broad suppression of genome maintenance mechanisms downstream of the oncogene KSHV-vGPCR

Krause, C. J., Popp, O., Thirunarayanan, N., Dittmar, G., Lipp, M., & Müller, G. (2016) · Oncotarget · doi:10.18632/oncotarget.7248 · Cited by 16

Functions that Protect Escherichia coli from Tightly Bound DNA-Protein Complexes Created by Mutant EcoRII Methyltransferase

Henderson, M. L., & Kreuzer, K. N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128092 · Cited by 16

Impediment of Replication Forks by Long Non-coding RNA Provokes Chromosomal Rearrangements by Error-Prone Restart

Watanabe, T., Marotta, M. L., Suzuki, R., Diede, S. J., Tapscott, S. J., Niida, A., Chen, X., Mouakkad, L., Kondratova, A. A., Giuliano, A. E., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.103 · Cited by 18

New origin firing is inhibited by APC/CCdh1activation in S-phase after severe replication stress

Ercilla, A., Llopis, A., Feu, S., Aranda, S., Ernfors, P., Freire, R., & Agell, N. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw132 · Cited by 16

Chromatin Architectural Factors as Safeguards against Excessive Supercoiling during DNA Replication

Ahmed, S. M., & Dröge, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124504 · Cited by 16

Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistancePreprint

Dolce, V., Dusi, S., Giannattasio, M., Joseph, C. R., Fumasoni, M., & Branzei, D. (2022) · Genes & Development · doi:10.1101/gad.349207.121 · Cited by 16

Fetal hepatocytes protect the HSPC genome via fetuin-A

Guo, X., Wang, Y.-D., Liu, Y.-J., Chu, L., Zhu, H., Hu, Y., Wu, R., Xie, H., Yu, J., Shuiping, L., et al. (2024) · Nature · doi:10.1038/s41586-024-08307-x · Cited by 15

The Budding Yeast Ubiquitin Protease Ubp7 Is a Novel Component Involved in S Phase Progression

Böhm, S., Szakál, B., Herken, B. W., Sullivan, M. R., Mihalevic, M. J., Kabbinavar, F. F., Branzei, D., Clark, N. L., & Bernstein, K. A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.671057 · Cited by 15

Infant birth outcomes are associated with DNA damage biomarkers as measured by the cytokinesis block micronucleus cytome assay: the DADHI study

Singh, M. D., Thomas, P., Hor, M., Almond, T., Owens, J. A., Hague, W. M., & Fenech, M. F. (2017) · Mutagenesis · doi:10.1093/mutage/gex001 · Cited by 15

Distinct cellular responses to replication stress leading to apoptosis or senescence

Lukášová, E., Řezáčová, M., Bačı́ková, A., Šebejová, L., Vávrová, J., & Kozubek, S. (2019) · FEBS Open Bio · doi:10.1002/2211-5463.12632 · Cited by 17

Histone dynamics during DNA replication stress

Hsu, C.-L., Chong, S. Y., Lin, C., & Kao, C.-F. (2021) · Journal of Biomedical Science · doi:10.1186/s12929-021-00743-5 · Cited by 20

The Role of Topoisomerase II in DNA Repair and Recombination in Arabidopsis thaliana

Martínez‐García, M., White, C. I., Franklin, F. C. H., & Sánchez‐Morán, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313115 · Cited by 15

Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe

Patel, J. A., Zezelic, C., Rageul, J., Saldanha, J., Khan, A., & Kim, H. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad363 · Cited by 15

Central Role of Ubiquitination in Genome Maintenance: DNA Replication and Damage Repair

Ghosh, S., & Saha, T. (2012) · ISRN Molecular Biology · doi:10.5402/2012/146748 · Cited by 15

Ontogeny of Unstable Chromosomes Generated by Telomere Error in Budding Yeast

Beyer, T. E., & Weinert, T. A. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006345 · Cited by 16

Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms

Saha, L. K., Kim, S., Kang, H., Akter, M. S., Choi, K., Sakuma, T., Yamamoto, T., Sasanuma, H., Hirota, K., Nakamura, J., et al. (2018) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22201 · Cited by 15

The archaeal ATPase PINA interacts with the helicase Hjm via its carboxyl terminal KH domain remodeling and processing replication fork and Holliday junction

Zhai, B., DuPrez, K. T., Han, X., Yuan, Z., Ahmad, S., Xu, C., Gu, L., Ni, J., Fan, L., & Shen, Y. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky451 · Cited by 16

APE1 is a master regulator of the ATR-/ATM-mediated DNA damage response

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Mitotic chromatin marking governs the segregation of DNA damage

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The checkpoint transcriptional response: Make sure to turn it off once you are satisfied

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Ku Stabilizes Replication Forks in the Absence of Brc1

Sánchez, A., & Russell, P. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126598 · Cited by 18

SLX4 Prevents GEN1-Dependent DSBs During DNA Replication Arrest Under Pathological Conditions in Human Cells

Malacaria, E., Franchitto, A., & Pichierri, P. (2017) · Scientific Reports · doi:10.1038/srep44464 · Cited by 17

The HLTF–PARP1 interaction in the progression and stability of damaged replication forks caused by methyl methanesulfonate

Shiu, J.-L., Wu, C.-K., Chang, S., Sun, Y.-J., Chen, Y., Lai, C., Chiu, W., Chang, W., Myung, K., Su, W., et al. (2020) · Oncogenesis · doi:10.1038/s41389-020-00289-5 · Cited by 15

The S-Phase Cyclin Clb5 Promotes rRNA Gene (rDNA) Stability by Maintaining Replication Initiation Efficiency in rDNA

Goto, M., Sasaki, M., & Kobayashi, T. (2021) · Molecular and Cellular Biology · doi:10.1128/mcb.00324-20 · Cited by 14

TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer

Swain, U., Friedlander, G., Sehrawat, U., Sarusi-Portuguez, A., Rotkopf, R., Ebert, C., Paz-Elizur, T., Dikstein, R., Carell, T., Geacintov, N. E., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136957 · Cited by 14

RFC5, regulated by circ_0038985/miR‐3614‐5p, functions as an oncogene in the progression of colorectal cancer

Yao, H., Zhou, X., Zhou, A., Chen, J., Chen, G., Shi, X., Shi, B., Tai, Q., Mi, X., Zhou, G., et al. (2023) · Molecular Carcinogenesis · doi:10.1002/mc.23523 · Cited by 14

Phosphorylation of a C-terminal auto-inhibitory domain increases SMARCAL1 activity

Carroll, C., Bansbach, C. E., Zhao, R., Jung, S. Y., Qin, J., & Cortez, D. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt929 · Cited by 14

G1/S and G2/M Cyclin-Dependent Kinase Activities Commit Cells to Death in the Absence of the S-Phase Checkpoint

Manfrini, N., Gobbini, E., Baldo, V., Trovesi, C., Lucchini, G., & Longhese, M. P. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00956-12 · Cited by 15

Systematic identification of long non-coding RNAs with cancer-testis expression patterns in 14 cancer types

Qin, N., Wang, C., Lü, Q., Ma, Z., Dai, J., Ma, H., Jin, G., Shen, H., & Hu, Z. (2017) · Oncotarget · doi:10.18632/oncotarget.21930 · Cited by 14

A whole genome RNAi screen identifies replication stress response genes

Kavanaugh, G. M., Ye, F., Mohni, K. N., Luzwick, J. W., Glick, G. G., & Cortez, D. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.09.024 · Cited by 16

Long-distance inflammatory and genotoxic impact of cancer in vivo

Bártek, J., Mistrík, M., & Bártková, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013093107 · Cited by 14

DNA replication timing reveals genome-wide features of transcription and fragility

Berkemeier, F., Cook, P. R., & Boemo, M. A. (2025) · Nature Communications · doi:10.1038/s41467-025-59991-w · Cited by 13

Exploring replication stress and cellular senescence as key targets in novel cancer therapies

Ray, S. K., & Mukherjee, S. (2025) · Cancer Genetics · doi:10.1016/j.cancergen.2025.09.002 · Cited by 14

Distinct roles of structure-specific endonucleases EEPD1 and Metnase in replication stress responses

Sharma, N., Speed, M. C., Allen, C., Maranon, D. G., Williamson, E. A., Singh, S., Hromas, R., & Nickoloff, J. A. (2020) · NAR Cancer · doi:10.1093/narcan/zcaa008 · Cited by 13

Protective Mechanisms Against DNA Replication Stress in the Nervous System

Charlier, C. F., & Martins, R. A. P. (2020) · Genes · doi:10.3390/genes11070730 · Cited by 16

Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress

Fumasoni, M., & Murray, A. W. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009875 · Cited by 13

DNA polymerase ε harmonizes topological states and R-loops formation to maintain genome integrity in Arabidopsis

Li, Q., Zhou, J., Li, S., Zhang, W., Du, Y., Li, K., Wang, Y., & Sun, Q. (2023) · Nature Communications · doi:10.1038/s41467-023-43680-7 · Cited by 13

The progress in the mechanistic studies of maintaining replication fork stability in eukaryotic cells

Liu, Y. (2014) · Shengming kexue

The DNA damage response during DNA replication

Branzei, D., & Foiani, M. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.003 · Cited by 240

Interplay of replication checkpoints and repair proteins at stalled replication forks

Branzei, D., & Foiani, M. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.02.018 · Cited by 133

Preventing replication fork collapse to maintain genome integrity

Cortez, D. (2015) · DNA Repair · doi:10.1016/j.dnarep.2015.04.026 · Cited by 223

Replication forks and replication checkpoints in repair

Branzei, D., & Foiani, M. (2007) · Topics in current genetics · doi:10.1007/978-3-540-71021-9_7