Cited by 1,228DNA Repair MechanismsCancer-related Molecular PathwaysFungal and yeast genetics research

Regulation of DNA repair throughout the cell cycle

Branzei, Dana, Foiani, Marco·2008·Nature Reviews Molecular Cell Biology

Abstract

The repair of DNA lesions that occur endogenously or in response to diverse genotoxic stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways that regulate specific DNA-repair mechanisms in the different phases of the cell cycle. Checkpoint-arrested cells resume cell-cycle progression once damage has been repaired, whereas cells with unrepairable DNA lesions undergo permanent cell-cycle arrest or apoptosis. Recent studies have provided insights into the mechanisms that contribute to DNA repair in specific cell-cycle phases and have highlighted the mechanisms that ensure cell-cycle progression or arrest in normal and cancerous cells.

Integrity signals

Registry

Crossref · 10.1038/nrm2351

Cites

159 of 159 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Branzei, D., & Foiani, M.
Affiliations
  • IFOM (IT)
  • University of Milan (IT)
Venue
Nature Reviews Molecular Cell Biology
Published
2008-02-20
Volume
9
Issue
4
Pages
297-308
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W2093814864
Cited by
1,228
References
159
Citations by year
2026: 18 · 2025: 51 · 2024: 54 · 2023: 48 · 2022: 50 · 2021: 72 · 2020: 71 · 2019: 91 · 2018: 119 · 2017: 107 · 2016: 57 · 2015: 66 · 2014: 61 · 2013: 77 · 2012: 67
FWCI
5.64
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
Funders
Associazione Italiana per la Ricerca sul Cancro
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
DNA repair, cell cycle, DNA damage checkpoint, cell cycle arrest, cell cycle progression, genome stability, genotoxic stress, apoptosis, DNA lesions, cancer cells
MeSH terms
Animals, Cell Cycle, DNA Damage, DNA Repair, Humans, Protein Kinases, Small Ubiquitin-Related Modifier Proteins, Ubiquitination

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review