Cited by 786DNA Repair MechanismsTelomeres, Telomerase, and SenescenceDNA and Nucleic Acid Chemistry

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Maintaining genome stability at the replication fork

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Branzei, Dana, Foiani, Marco·2010·Nature Reviews Molecular Cell Biology

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Abstract

Aberrant DNA replication is a major source of the mutations and chromosome rearrangements that are associated with pathological disorders. When replication is compromised, DNA becomes more prone to breakage. Secondary structures, highly transcribed DNA sequences and damaged DNA stall replication forks, which then require checkpoint factors and specialized enzymatic activities for their stabilization and subsequent advance. These mechanisms ensure that the local DNA damage response, which enables replication fork progression and DNA repair in S phase, is coupled with cell cycle transitions. The mechanisms that operate in eukaryotic cells to promote replication fork integrity and coordinate replication with other aspects of chromosome maintenance are becoming clear.

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Authors: Branzei, D., & Foiani, M.
Affiliations: IFOM (IT)
University of Milan (IT)
ORCID: Branzei, Dana
Foiani, Marco
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2010-03
Volume: 11
Issue: 3
Pages: 208-219
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm2852
OpenAlex: W2063979868
Cited by: 786
References: 155
Citations by year: 2026: 16 · 2025: 15 · 2024: 27 · 2023: 22 · 2022: 30 · 2021: 36 · 2020: 51 · 2019: 48 · 2018: 38 · 2017: 56 · 2016: 70 · 2015: 67 · 2014: 73 · 2013: 82 · 2012: 73
FWCI: 6.60
Type: journal article
Language: en
Open access: green
zenodo.org
Licence: other-oa
www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Funders: Associazione Italiana per la Ricerca sul Cancro
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: genome stability, DNA replication, replication fork, replication fork stalling, DNA secondary structure, DNA damage response, DNA repair, S phase, chromosome maintenance, genetic mutations, chromosomal rearrangements
MeSH terms: Animals, DNA, DNA Damage, DNA Repair, DNA Replication, Humans, Models, Biological, Nucleic Acid Conformation, Replication Origin, Genomic Instability

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Maintaining genome stability at the replication fork

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