The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.
Mitochondria and cell death: outer membrane permeabilization and beyond
Abstract
Mitochondrial outer membrane permeabilization (MOMP) is often required for activation of the caspase proteases that cause apoptotic cell death. Various intermembrane space (IMS) proteins, such as cytochrome c, promote caspase activation following their mitochondrial release. As a consequence, mitochondrial outer membrane integrity is highly controlled, primarily through interactions between pro- and anti-apoptotic members of the B cell lymphoma 2 (BCL-2) protein family. Following MOMP by pro-apoptotic BCL-2-associated X protein (BAX) or BCL-2 antagonist or killer (BAK), additional regulatory mechanisms govern the mitochondrial release of IMS proteins and caspase activity. MOMP typically leads to cell death irrespective of caspase activity by causing a progressive decline in mitochondrial function, although cells can survive this under certain circumstances, which may have pathophysiological consequences.
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“MOMP directly promotes the cytosolic release of apoptogenic factors that normally reside in the mitochondrial intermembrane space [40, 44, 156]. These mitochondrial proteins include (but are not limited to) cytochrome c, somatic (CYCS), which usually operates as an electron shuttle in the mitochondrial respiratory chain [157–160], and diablo IAP-binding mitochondrial protein (DIABLO; also known as”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [40]
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Conage‐Pough, J. E., & Boise, L. H. (2018) · The FEBS Journal · doi:10.1111/febs.14505 · Cited by 32
Apoptotic caspases cut down the immunogenicity of radiation
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Metadata
- Authors
- Tait, S. W. G., & Green, D. R.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Green, Douglas R.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2010-08-04
- Volume
- 11
- Issue
- 9
- Pages
- 621-632
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2066571367
- Cited by
- 2,593
- References
- 151
- Citations by year
- 2026: 142 · 2025: 110 · 2024: 104 · 2023: 131 · 2022: 143 · 2021: 182 · 2020: 188 · 2019: 160 · 2018: 214 · 2017: 195 · 2016: 200 · 2015: 194 · 2014: 203 · 2013: 175 · 2012: 134
- FWCI
- 11.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial outer membrane permeabilization, apoptosis, caspase activation, Bcl-2 family proteins, Bax, Bak, cytochrome c release, mitochondrial function, cell death
- MeSH terms
- Animals, Humans, Mitochondria, Cell Death, Caspases, bcl-2-Associated X Protein, Mitochondrial Membranes
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