Cited by 2,593Cell death mechanisms and regulationMitochondrial Function and PathologyAutophagy in Disease and Therapy

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Mitochondria and cell death: outer membrane permeabilization and beyond

Tait, Stephen W. G., Green, Douglas R.·2010·Nature Reviews Molecular Cell Biology

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Abstract

Mitochondrial outer membrane permeabilization (MOMP) is often required for activation of the caspase proteases that cause apoptotic cell death. Various intermembrane space (IMS) proteins, such as cytochrome c, promote caspase activation following their mitochondrial release. As a consequence, mitochondrial outer membrane integrity is highly controlled, primarily through interactions between pro- and anti-apoptotic members of the B cell lymphoma 2 (BCL-2) protein family. Following MOMP by pro-apoptotic BCL-2-associated X protein (BAX) or BCL-2 antagonist or killer (BAK), additional regulatory mechanisms govern the mitochondrial release of IMS proteins and caspase activity. MOMP typically leads to cell death irrespective of caspase activity by causing a progressive decline in mitochondrial function, although cells can survive this under certain circumstances, which may have pathophysiological consequences.

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Authors: Tait, S. W. G., & Green, D. R.
Affiliations: St. Jude Children's Research Hospital (US)
Corresponding author: Green, Douglas R.
ORCID: Tait, Stephen W. G.
Green, Douglas R.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2010-08-04
Volume: 11
Issue: 9
Pages: 621-632
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm2952
OpenAlex: W2066571367
Cited by: 2,593
References: 151
Citations by year: 2026: 142 · 2025: 110 · 2024: 104 · 2023: 131 · 2022: 143 · 2021: 182 · 2020: 188 · 2019: 160 · 2018: 214 · 2017: 195 · 2016: 200 · 2015: 194 · 2014: 203 · 2013: 175 · 2012: 134
FWCI: 11.64
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: mitochondrial outer membrane permeabilization, apoptosis, caspase activation, Bcl-2 family proteins, Bax, Bak, cytochrome c release, mitochondrial function, cell death
MeSH terms: Animals, Humans, Mitochondria, Cell Death, Caspases, bcl-2-Associated X Protein, Mitochondrial Membranes

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Mitochondria and cell death: outer membrane permeabilization and beyond

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