The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Dynamic niches in the origination and differentiation of haematopoietic stem cells
Open accessAbstract
Haematopoietic stem cells (HSCs) are multipotent, self-renewing progenitors that generate all mature blood cells. HSC function is tightly controlled to maintain haematopoietic homeostasis, and this regulation relies on specialized cells and factors that constitute the haematopoietic 'niche', or microenvironment. Recent discoveries, aided in part by technological advances in in vivo imaging, have engendered a new appreciation for the dynamic nature of the niche, identifying novel cellular and acellular niche components and uncovering fluctuations in the relative importance of these components over time. These new insights significantly improve our understanding of haematopoiesis and raise fundamental questions about what truly constitutes a stem cell niche.
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Citations
Cites
Matrix elasticity directs stem cell lineage specification
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Defining the Epithelial Stem Cell Niche in Skin
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Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
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Self-citationBone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
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“This observation stems most convincingly from work in which HSCs isolated from adipocyte-rich tail vertebrae showed reduced activity in transplantation assays, as compared to HSCs isolated from adipocyte-poor thoracic vertebra”
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
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Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis
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Cited by
Extracellular matrix: A dynamic microenvironment for stem cell niche
Gattazzo, F., Urciuolo, A., & Bonaldo, P. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.01.010 · Cited by 1,294
Direct measurement of local oxygen concentration in the bone marrow of live animals
Spencer, J. A., Ferraro, F., Roussakis, E., Klein, A., Wu, J., Runnels, J. M., Zaher, W., Mortensen, L. J., Alt, C., Turcotte, R., et al. (2014) · Nature · doi:10.1038/nature13034 · Cited by 1,167
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Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro
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Crucian, B. E., Choukèr, A., Simpson, R. J., Mehta, S., Marshall, G., Smith, S. M., Zwart, S. R., Heer, M., Ponomarev, S., Whitmire, A., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01437 · Cited by 421
Metadata
- Authors
- Wang, L. D., & Wagers, A. J.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2011-09-02
- Volume
- 12
- Issue
- 10
- Pages
- 643-655
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2009286164
- Cited by
- 343
- References
- 12
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- green
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