The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
All tangled up: how cells direct, manage and exploit topoisomerase function
Open accessAbstract
Topoisomerases are complex molecular machines that modulate DNA topology to maintain chromosome superstructure and integrity. Although capable of stand-alone activity in vitro, topoisomerases are frequently linked to larger pathways and systems that resolve specific DNA superstructures and intermediates arising from cellular processes such as DNA repair, transcription, replication and chromosome compaction. Topoisomerase activity is indispensible to cells, but requires the transient breakage of DNA strands. This property has been exploited, often for significant clinical benefit, by various exogenous agents that interfere with cell proliferation. Despite decades of study, surprising findings involving topoisomerases continue to emerge with respect to their cellular function, regulation and utility as therapeutic targets.
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Cites
Lysine acetylation targets protein complexes and co-regulates major cellular functions
Choudhary, C., Kumar, C., Gnad, F., Nielsen, M. L., Rehman, M., Walther, T. C., Olsen, J. V., & Mann, M. (2009) · Science · doi:10.1126/science.1175371 · Cited by 4,040
Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I
Kim, N., Huang, S.-Y. N., Williams, J. S., Li, Y. C., Clark, A. B., Cho, J.-E., Kunkel, T. A., Pommier, Y., & Jinks-Robertson, S. (2011) · Science · doi:10.1126/science.1205016 · Cited by 291
S Phase and G2 Arrests Induced by Topoisomerase I Poisons Are Dependent on ATR Kinase Function
Cliby, W. A., Lewis, K. A., Lilly, K. K., & Kaufmann, S. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106287200 · Cited by 205
Role for topoisomerase 1 in transcription-associated mutagenesis in yeast
Lippert, M. J., Kim, N., Cho, J.-E., Larson, R. P., Schoenly, N. E., O'Shea, S. H., & Jinks-Robertson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012363108 · Cited by 97
Brochier-Armanet, C., & Forterre, P. (2007) · Archaea · doi:10.1155/2006/582916 · Cited by 97
Cited by
Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes
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Topoisomerases as anticancer targets
Delgado, J. L., Hsieh, C.-M., Chan, N.-L., & Hiasa, H. (2018) · Biochemical Journal · doi:10.1042/bcj20160583 · Cited by 481
Topoisomerases facilitate transcription of long genes linked to autism
King, I. F., Yandava, C. N., Mabb, A. M., Hsiao, J. S., Huang, H.-S., Pearson, B. L., Calabrese, J. M., Starmer, J., Parker, J. S., Magnuson, T., et al. (2013) · Nature · doi:10.1038/nature12504 · Cited by 438
New Mechanistic and Functional Insights into DNA Topoisomerases
Chen, S. H., Chan, N.-L., & Hsieh, T.-S. (2013) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061809-100002 · Cited by 369
Bacterial Chromosome Organization and Segregation
Badrinarayanan, A., Le, T. B. K., & Laub, M. T. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125211 · Cited by 289
Metadata
- Authors
- Vos, S. M., Tretter, E. M., Schmidt, B. H., & Berger, J. M.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2011-11-23
- Volume
- 12
- Issue
- 12
- Pages
- 827-841
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1994490060
- Cited by
- 650
- References
- 5
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Vos, S. M., Tretter, E. M., Schmidt, B. H., & Berger, J. M. (2011). All tangled up: how cells direct, manage and exploit topoisomerase function. Nature Reviews Molecular Cell Biology. https://doi.org/10.1038/nrm3228
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
