The DOI matches its Crossref record; 150 of the 150 references it cites were found in a registry or an index.
Bacterial Chromosome Organization and Segregation
Open accessAbstract
If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long, approximately 1,000 times the length of a cell. Not only must cells massively compact their genetic material, but they must also organize their DNA in a manner that is compatible with a range of cellular processes, including DNA replication, DNA repair, homologous recombination, and horizontal gene transfer. Recent work, driven in part by technological advances, has begun to reveal the general principles of chromosome organization in bacteria. Here, drawing on studies of many different organisms, we review the emerging picture of how bacterial chromosomes are structured at multiple length scales, highlighting the functions of various DNA-binding proteins and the impact of physical forces. Additionally, we discuss the spatial dynamics of chromosomes, particularly during their segregation to daughter cells. Although there has been tremendous progress, we also highlight gaps that remain in understanding chromosome organization and segregation.
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Cites
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Self-citation
Cited by
Intrinsically Disordered Proteins and Their “Mysterious” (Meta)Physics
Uversky, V. N. (2019) · Frontiers in Physics · doi:10.3389/fphy.2019.00010 · Cited by 532
The bacterial cell cycle, chromosome inheritance and cell growth.
Reyes-Lamothe, R., & Sherratt, D. J. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0212-7 · Cited by 131
Deep, A., Gu, Y., Gao, Y.-Q., Ego, K. M., Herzik, M. A., Zhou, H., & Corbett, K. D. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.09.008 · Cited by 106
Loop-extruders alter bacterial chromosome topology to direct entropic forces for segregation
Harju, J., van Teeseling, M. C. F., & Broedersz, C. P. (2024) · Nature Communications · doi:10.1038/s41467-024-49039-w · Cited by 27
“Many bacteria contain a single circular chromosome that is simultaneously replicated and segregated during the cell cycle [1, 2, 3].”
Dynamics of chromosome organization in a minimal bacterial cell
Gilbert, B. R., Thornburg, Z. R., Brier, T. A., Stevens, J. A., Grünewald, F., Stone, J. E., Marrink, S. J., & Luthey-Schulten, Z. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1214962 · Cited by 19
“…is only one order-of-magnitude and we can conjecture that this might be due to Syn3A and E. coli compensating for their lack of a parAB S system (Livny et al., 2007; Badrinarayanan et al., 2015) that preferentially loads SMC complexes onto the chromosome (Marbouty et al., 2015; Tran et al., 2017).”
Metadata
- Authors
- Badrinarayanan, A., Le, T. B. K., & Laub, M. T.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2015-11-13
- Volume
- 31
- Issue
- 1
- Pages
- 171-199
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2101425827
- Cited by
- 289
- References
- 150
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- green
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