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Endoplasmic reticulum-mitochondria contacts: Function of the junction
Open accessAbstract
The most well-characterized organelle contact sites are those between the endoplasmic reticulum (ER) and mitochondria. Increased understanding is being gained of how ER-mitochondria contact sites are organized and which factors converge at this interface, some of which may provide a tethering function. The role of the ER-mitochondria junction in coordinating the functions of these two organelles is also becoming clearer, and it has been shown to be involved in the regulation of lipid synthesis, Ca(2+) signalling and the control of mitochondrial biogenesis and intracellular trafficking.
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“Besides controlling Ca2+ flux, MAM participate in lipid synthesis, membrane stability, mitochondrial dynamics, and ROS signaling [99–101].”
From Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function (2019) · cites this paper as [99]
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“Mitochondria shared greater location similarity with the ER (SEC61β and SERCA) than any other structures, consistent with the functional interactions between these cellular structures22,23.”
From Integrated intracellular organization and its variations in human iPS cells (2023) · cites this paper as [22]
In the citing paper
“MAMs play a vital role in lipid transport, Ca2+ signaling, cell survival, and energy metabolism [234], and have been implicated in diseases including Alzheimer’s disease [235], cancer [236], lysosomal storage disease [237], diabetes mellitus [238,239], obesity, and metabolic disorders [240].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [234]
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“The MAM functions to transfer lipids and calcium ions between the 2 organelles, to define the sites for mitochondrial division, and to regulate cell survival [6,10].”
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“Both the MCS between ER and mitochondria and ER and plasma membrane are involved in an enormous number of functions taking place at the two organelles, including Ca2+ transport and the synthesis of phospholipids (Rowland & Voeltz, 2012; Stefan et al., 2013).”
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Mitochondrial Ca2+ Remodeling is a Prime Factor in Oncogenic Behavior
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“MCSs control organelle dynamics and distribution ER-mitochondria MCSs have been shown to play a role in mitochondrial fusion-fission and overall motility.(60) These processes are crucial for mitochondrial biogenesis, distribution, and function, and their alteration results in inherited or agerelated neurodegenerative…”
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“It exchanges lipids and proteins with these organelles to regulate their biogenesis and function (4, 5).”
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“, mitochondria and nucleus) by the membrane contact sites (Rowland and Voeltz, 2012; Matteis and Rega, 2015; Wu et al., 2018; Lee et al., 2020; Qin et al., 2020).”
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“11 MAMs are altered during the transition from adaptive to maladaptive myocardial hypertrophy, contributing to heart failure progression.”
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“The MAM plays important roles in multiple cellular functions, including maintaining intracellular Ca2+ homeostasis.”
BackgroundInfluentialRole of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans
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“Due to the intimate interaction of the ER and the mitochondria upon ER calcium release [67,68], a high concentration of calcium is present in close apposition between the ER and mitochondria causing the mitochondria to act as a calcium buffer to stabilize cytosolic calcium levels and, conversely, calcium is a key play…”
BackgroundCryoAPEX – an electron tomography tool for subcellular localization of membrane proteins
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“The functional relevance of these organellar contact points is of research interest and, in the case of the ER, they are known to be portals of lipid and calcium transport (English and Voeltz, 2013; Rowland and Voeltz, 2012).”
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“In response to harsh environmental conditions, the ER and mitochondria utilize sensor proteins to activate signaling pathways that contribute to the regulation of cell life or death [1].”
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“Thus, MIRO is a critical regulator of mt movement.(87)”
BackgroundInfluentialSathyamurthy, V. H., Nagarajan, Y., & Parvathi, V. D. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03971-6 · Cited by 31
“Lipid metabolism, Ca 2+ signaling, mitochondrial replication, and coordinated dynamics of the two organelles are the four primary activities that have been identified for ER-mitochon-dria interactions [6].”
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Bellucci, M., Marchis, F. D., & Pompa, A. (2017) · Journal of Experimental Botany · doi:10.1093/jxb/erx286 · Cited by 34
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“Accordingly, steatosis is a common feature in HCV-infected hepatocytes [24] and it is characterized by high oxidation rates with a consequent increase of electron delivery to the ETC that might cause ROS overproduction.”
BackgroundEvans, A. M., Fameli, N., Ogunbayo, O. A., Duan, J., & Navarro‐Dorado, J. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-5071-0 · Cited by 30
“These aside, mitochondria-SR junctions regulate mitochondrial energy metabolism, lipid transport, apoptosis and SR Ca2+ loading (Rowland and Voeltz, 2012) and lysosome-SR junctions underpin evoked calcium-induced calcium release (CICR) from the S/ER which may in turn modulate, for example,…”
Li, X., Li, Q., Jiang, X., Song, S., Zou, W., Yang, Q., Liu, S., Chen, S., & Wang, C. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01914-1 · Cited by 36
Molecular mechanism of mitochondrial calcium uptake
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“The endoplasmic reticulum (ER) and mitochondria significantly contribute to cellular Ca homeostasis [9].”
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Beasley, H. K., Rodman, T. A., Collins, G. V., Hinton, A. O., Jr., & Exil, V. J. (2021) · Cells · doi:10.3390/cells10071750 · Cited by 29
Nanoscale details of mitochondrial constriction revealed by cryoelectron tomography
Mageswaran, S. K., Grotjahn, D. A., Zeng, X., Barad, B. A., Medina, M., Hoang, M. H., Dobro, M. J., Chang, Y., Xu, M., Yang, W. Y., et al. (2023) · Biophysical Journal · doi:10.1016/j.bpj.2023.07.030 · Cited by 36
“Insomere-ports, ER tubules are proposed to wrap around the mitochondria, contributing to force generation and initiating constriction on their own (42).”
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“Accumulating evidence suggests that mitochondria and the endoplasmic reticulum (ER) physically interact with one another and play roles in various cellular processes, including phospholipid biosynthesis and mitochondrial fission (Rowland and Voeltz, 2012; Friedman and Nunnari, 2014; Vance, 2014).”
BackgroundBullen, A., West, T. O., Moores, C. A., Ashmore, J. F., Fleck, R. A., MacLellan‐Gibson, K., & Forge, A. (2015) · Journal of Cell Science · doi:10.1242/jcs.170761 · Cited by 30
A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death
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“The ER and mitochondria share physical connections (36) and both ATP13A2 and a-Syn have also been directly implicated in the homeostasis of mitochondria (37,38).”
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“ER-mitochondria contact sites (ERMCS) are physical contacts between these two endomembranes, which are important for various processes such as mitochondrial fission or lipid transfer (Rowland & Voeltz, 2012).”
BackgroundMitochondrial roles of the psychiatric disease risk factor DISC1.
Norkett, R., Modi, S., & Kittler, J. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2016.12.025 · Cited by 25
“Calcium buffering is, in turn, facilitated by ER-mitochondria contacts (Rowland and Voeltz, 2012), another aspect of mitochondrial biology in which DISC1 is implicated.”
BackgroundInterplay of Energetics and ER Stress Exacerbates Alzheimer's Amyloid-β (Aβ) Toxicity in Yeast
Chen, X., Bisschops, M. M. M., Agarwal, N. R., Ji, B., Shanmugavel, K. P., & Petranović, D. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00232 · Cited by 30
“Mitochondria furthermore communicate directly with ER through MAM (mitochondria-associated ER membranes) to regulate several fundamental cellular processes (Csordás et al., 2006; Rowland and Voeltz, 2012).”
BackgroundMorimoto, M., Waller‐Evans, H., Ammous, Z., Song, X., Strauss, K. A., Pehli̇van, D., Gonzaga-Jauregui, C. G., Puffenberger, E. G., Holst, C. R., Karaca, E., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.09.014 · Cited by 29
“Wepostulated that the increased susceptibility to oxidative stressmay be a secondary downstream effect of CCDC47 deficiency since Ca2þ signaling is integral for mitochondrial function and there is extensive crosstalk between the Ca2þ and ROS signaling systems.(27,28) However, we observed that fibroblasts from probands…”
BackgroundPannexin 2 Localizes at ER-Mitochondria Contact Sites
Vasseur, M. L., Chen, V. C., Huang, K., Vogl, W. A., & Naus, C. C. G. (2019) · Cancers · doi:10.3390/cancers11030343 · Cited by 30
Network organisation and the dynamics of tubules in the endoplasmic reticulum
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“This Ca2+ exchange is essential for ATP generation, which keeps autophagy at basal levels, while excessive Ca2+ uptake leads to apoptosis [27].”
BackgroundLi, Z., Cao, Y., Pei, H., Ma, L., Yang, Y., & Li, H. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1158204 · Cited by 30
“They are not the collection of membranes but the employment of the proteinaceous tethers (Rowland and Voeltz, 2012), which play a key role in many important metabolic processes including the transfer of calcium, mitochondrial dynamics, lipid synthesis, autophagy, apoptosis, and inflammation.”
BackgroundNhung, T. T. M., Long, N. P., Nghi, T. D., Suh, Y., Anh, N. H., Jung, C. W., Triet, H. M., Jung, M., Woo, Y., Yoo, J. Y., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2303402120 · Cited by 28
Video-rate 3D imaging of living cells using Fourier view-channel-depth light field microscopy
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Positioning regulation of organelle network via Chinese microneedle
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The role of taurine through endoplasmic reticulum in physiology and pathology
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Metadata
- Authors
- Rowland, A. A., & Voeltz, G. K.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Voeltz, Gia K.
- ORCID
- Voeltz, Gia K.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2012-09-20
- Volume
- 13
- Issue
- 10
- Pages
- 607-615
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC5111635
- OpenAlex
- W2117692658
- Cited by
- 1,018
- References
- 84
- Citations by year
- 2026: 67 · 2025: 81 · 2024: 89 · 2023: 81 · 2022: 81 · 2021: 79 · 2020: 77 · 2019: 68 · 2018: 70 · 2017: 76 · 2016: 67 · 2015: 71 · 2014: 57 · 2013: 51 · 2012: 3
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM07135, R01GM083977, T32GM007135)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- endoplasmic reticulum-mitochondria contacts, organelle tethering, lipogenesis, calcium signaling, mitochondrial biogenesis, intracellular trafficking
- MeSH terms
- Animals, Endoplasmic Reticulum, Lipids, Mitochondria, Signal Transduction, Calcium Signaling, Protein Transport, Mitochondrial Membranes, Mitochondrial Turnover
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