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The Molecular Basis for the Calcium-Dependent Slow Afterhyperpolarization in CA1 Hippocampal Pyramidal Neurons

Sahu, Giriraj, Turner, Ray W.·2021·Frontiers in Physiology
DOI 10.3389/fphys.2021.759707PMC PMC8730529
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Abstract

Neuronal signal transmission depends on the frequency, pattern, and timing of spike output, each of which are shaped by spike afterhyperpolarizations (AHPs). There are classically three post-spike AHPs of increasing duration categorized as fast, medium and slow AHPs that hyperpolarize a cell over a range of 10 ms to 30 s. Intensive early work on CA1 hippocampal pyramidal cells revealed that all three AHPs incorporate activation of calcium-gated potassium channels. The ionic basis for a fAHP was rapidly attributed to the actions of big conductance (BK) and the mAHP to small conductance (SK) or Kv7 potassium channels. In stark contrast, the ionic basis for a prominent slow AHP of up to 30 s duration remained an enigma for over 30 years. Recent advances in pharmacological, molecular, and imaging tools have uncovered the expression of a calcium-gated intermediate conductance potassium channel (IK, KCa3.1) in central neurons that proves to contribute to the slow AHP in CA1 hippocampal pyramidal cells. Together the data show that the sAHP arises in part from a core tripartite complex between Cav1.3 (L-type) calcium channels, ryanodine receptors, and IK channels at endoplasmic reticulum-plasma membrane junctions. Work on the sAHP in CA1 pyramidal neurons has again quickened pace, with identified contributions by both IK channels and the Na-K pump providing answers to several mysteries in the pharmacological properties of the sAHP.

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Metadata

Authors
Sahu, G., & Turner, R. W.
Venue
Frontiers in Physiology
Publisher
Frontiers Media SA
Published
2021-12-22
Volume
12
ISSN
1664-042X
DOI
10.3389/fphys.2021.759707
PMC
PMC8730529
Cited by
39
References
7
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • Natural Sciences and Engineering Research Council of Canada
  • Canadian Institutes of Health Research
  • International Society for Neurochemistry

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