Systems and synthetic biology approaches to alter plant cell walls and reduce biomass recalcitrance
Open accessAbstract
Fine-tuning plant cell wall properties to render plant biomass more amenable to biofuel conversion is a colossal challenge. A deep knowledge of the biosynthesis and regulation of plant cell wall and a high-precision genome engineering toolset are the two essential pillars of efforts to alter plant cell walls and reduce biomass recalcitrance. The past decade has seen a meteoric rise in use of transcriptomics and high-resolution imaging methods resulting in fresh insights into composition, structure, formation and deconstruction of plant cell walls. Subsequent gene manipulation approaches, however, commonly include ubiquitous mis-expression of a single candidate gene in a host that carries an intact copy of the native gene. The challenges posed by pleiotropic and unintended changes resulting from such an approach are moving the field towards synthetic biology approaches. Synthetic biology builds on a systems biology knowledge base and leverages high-precision tools for high-throughput assembly of multigene constructs and pathways, precision genome editing and site-specific gene stacking, silencing and/or removal. Here, we summarize the recent breakthroughs in biosynthesis and remodelling of major secondary cell wall components, assess the impediments in obtaining a systems-level understanding and explore the potential opportunities in leveraging synthetic biology approaches to reduce biomass recalcitrance.
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A change in the composition of cell walls may improve biofuel production.
“A change in the composition of cell walls may improve biofuel production.”
From Recent Developments in Lignocellulosic Biofuels, a Renewable Source of Bioenergy (2022) · cites this paper as [80]
Improvement in biofuel production from lignocellulosic biomass may be achieved through modern approaches of molecular biology, synthetic biology, and systems biology to improve plant cell wall digestibility.
“This may lead to improvement in biofuel production from lignocellulosic biomass through the employment of modern approaches of molecular biology, along with synthetic and systemic biology, to improve plant cell wall digestibility [31,79,80].”
From Recent Developments in Lignocellulosic Biofuels, a Renewable Source of Bioenergy (2022) · cites this paper as [80]
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Biosynthesis of non-cellulosic polysaccharides of plant cell walls
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Bioenergy research: a new paradigm in multidisciplinary research
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Self-citationCoherent Raman Microscopy Analysis of Plant Cell Walls
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Research works printed but not linked: 1
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From first generation biofuels to advanced solar biofuels
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Recent Developments in Lignocellulosic Biofuels, a Renewable Source of Bioenergy
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- Authors
- Kalluri, U. C., Yin, H., Yang, X., & Davison, B. H.
- Affiliations
- Oak Ridge National Laboratory (US)
- Corresponding author
- Kalluri, Udaya C.
- Venue
- Plant Biotechnology Journal
- Publisher
- Wiley
- Published
- 2014-11-03
- Volume
- 12
- Issue
- 9
- Pages
- 1207-1216
- ISSN
- 1467-7644 (ISSN-L)
- 1467-7652
- PMC
- PMC4265275
- OpenAlex
- W2129256046
- Cited by
- 54
- References
- 114
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 5 · 2019: 7 · 2018: 3 · 2017: 3 · 2016: 10 · 2015: 8
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Plant Biotechnology Journal (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- Biological and Environmental Research
- U.S. Department of Energy (DE–AC05–00OR22725)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Bioenergy crop production and management
- Keywords
- plant cell wall, biomass recalcitrance, biofuel feedstock, cell wall biosynthesis, cell wall remodeling, synthetic biology, genome editing, gene stacking, gene silencing, pleiotropy, systems biology, lignin, hemicellulose, pectin
- MeSH terms
- Cell Wall, Biomass, Systems Biology, Biosynthetic Pathways, Synthetic Biology, Plant Cells
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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